Navigation Links
Study measures single-molecule machines in action
Date:7/6/2010

In the development of future molecular devices, new display technologies, and "artificial muscles" in nanoelectromechanical devices, functional molecules are likely to play a primary role.

Rotaxanes, one family of such molecules, are tiny, mechanically interlocked structures that consist of a dumbell-shaped molecule whose rod section is encircled by a ring. These structures behave as molecular "machines," with the ring moving along the rod from one station to another when stimulated by a chemical reaction, light or acidity.

To realize the potential of these molecular machines, however, it is necessary to understand and to measure their function at the nanoscale. Previous methods for observing their operation have involved chemical measurements in solution and studying collections of them attached to surfaces, but neither has provided an accurate picture of their function in environments that are relevant to molecular-device operation.

Now, a multidisciplinary team of researchers from UCLA, Northwestern University, UC Merced, Pennsylvania State University and Japan has succeeded in observing single-molecule interactions of bistable rotaxanes functioning in their native environment.

The team's findings are published in the current edition of the journal ACS Nano.

Led by Paul Weiss from UCLA and Fraser Stoddart from Northwestern University, the team developed a molecular design that firmly attached rotaxanes to a surface, enabling them to be individually examined in their native environment by a scanning tunneling microscope (STM). Using this technology, the researchers were able to record station changes by the rotaxanes' rings along their rods in response to electrochemical signals.

Previously, rotaxanes had to be grouped for study because of their mobility and flexibility when attached to surfaces. And because STM instruments utilize an atomically thin tip to feel out nanoscale surfaces ― in much the same way a blind person reads Braille ― the rotaxanes' flexible nature made it difficult to study them individually. The research team's molecular design, however, helped significantly reduce this flexibility.

The STM developed by the team enables much more detailed studies of molecular machines, leading to greater understanding of how they interact with their neighbors and how they might work together in nanoelectromechanical devices.


'/>"/>

Contact: Mike Rodewald
mrodewald@cnsi.ucla.edu
310-267-5883
University of California - Los Angeles
Source:Eurekalert

Related biology technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
3. Kline Study: Better Brushing Habits Boost European Oral Care Sales
4. Evotec to Present Details of the Positive Phase II Study in Insomnia With EVT 201 at the Worldsleep07 Congress in Cairns/Australia
5. NASA study will help stop stowaways to Mars
6. New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome
7. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
8. Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201
9. Study Supports Use of GlycoMark Blood Test to Evaluate Therapy in Children with Diabetes
10. Quigley Corporation Releases Update on Quigley Pharmas Phase IIb Clinical Study of QR-333 in Diabetic Peripheral Neuropathy
11. Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... Opal Kelly, a ... device-to-computer interconnect using USB or PCI Express, announced the FOMD-ACV-A4, the company's first ... a small, thin, SODIMM-style module that fits a standard 204-pin SODIMM socket for ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... their exceptionally efficient human mesenchymal stem/stromal cell (hMSC) expansion medium. This ... products engineered to radically streamline culture processes, minimize processing time, significantly decrease ...
(Date:12/8/2016)... , Dec. 8, 2016  HedgePath Pharmaceuticals, Inc. ... discovers, develops and plans to commercialize innovative therapeutics ... of common stock were approved for trading on ... trading on the OTCQX, effective today, under the ... the OTCQX market, companies must meet high financial ...
(Date:12/7/2016)... San Diego (PRWEB) , ... December 07, 2016 ... ... safety data from its phase I/II dose escalation and expansion clinical trial for ... 2016 in Vienna, Austria. The purpose of the trial was to determine the ...
Breaking Biology Technology:
(Date:11/16/2016)... Nov. 16, 2016 Sensory Inc ., ... security for consumer electronics, and VeriTran , ... retail industry, today announced a global partnership that ... to authenticate users of mobile banking and mobile ... software which requires no specialized biometric scanners, ...
(Date:6/27/2016)... 2016 Research and Markets has announced the ... report to their offering. The ... to grow at a CAGR of 12.28% during the period ... an in-depth market analysis with inputs from industry experts. The report ... years. The report also includes a discussion of the key vendors ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
Breaking Biology News(10 mins):