Navigation Links
Study measures single-molecule machines in action
Date:7/6/2010

In the development of future molecular devices, new display technologies, and "artificial muscles" in nanoelectromechanical devices, functional molecules are likely to play a primary role.

Rotaxanes, one family of such molecules, are tiny, mechanically interlocked structures that consist of a dumbell-shaped molecule whose rod section is encircled by a ring. These structures behave as molecular "machines," with the ring moving along the rod from one station to another when stimulated by a chemical reaction, light or acidity.

To realize the potential of these molecular machines, however, it is necessary to understand and to measure their function at the nanoscale. Previous methods for observing their operation have involved chemical measurements in solution and studying collections of them attached to surfaces, but neither has provided an accurate picture of their function in environments that are relevant to molecular-device operation.

Now, a multidisciplinary team of researchers from UCLA, Northwestern University, UC Merced, Pennsylvania State University and Japan has succeeded in observing single-molecule interactions of bistable rotaxanes functioning in their native environment.

The team's findings are published in the current edition of the journal ACS Nano.

Led by Paul Weiss from UCLA and Fraser Stoddart from Northwestern University, the team developed a molecular design that firmly attached rotaxanes to a surface, enabling them to be individually examined in their native environment by a scanning tunneling microscope (STM). Using this technology, the researchers were able to record station changes by the rotaxanes' rings along their rods in response to electrochemical signals.

Previously, rotaxanes had to be grouped for study because of their mobility and flexibility when attached to surfaces. And because STM instruments utilize an atomically thin tip to feel out nanoscale surfaces 
'/>"/>

Contact: Mike Rodewald
mrodewald@cnsi.ucla.edu
310-267-5883
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
3. Kline Study: Better Brushing Habits Boost European Oral Care Sales
4. Evotec to Present Details of the Positive Phase II Study in Insomnia With EVT 201 at the Worldsleep07 Congress in Cairns/Australia
5. NASA study will help stop stowaways to Mars
6. New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome
7. Study Published in Clinical Cancer Research Confirms Potential Of Peregrines Bavituximab Combined With Radiation In Lung Cancer
8. Evotec Reports Details of the Positive Proof-of-Concept Phase II Study in Insomnia With EVT 201
9. Study Supports Use of GlycoMark Blood Test to Evaluate Therapy in Children with Diabetes
10. Quigley Corporation Releases Update on Quigley Pharmas Phase IIb Clinical Study of QR-333 in Diabetic Peripheral Neuropathy
11. Biodel Inc. Announces VIAject(TM) Phase II Meal Study Data at the 2007 European Association for the Study of Diabetes Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... With the accelerated aging of ... expenditure as well as the improved medical care ... reagent industry has been developing quickly, especially in ... Chinese in vitro diagnostics market size reached RMB22.98 ... vitro diagnostic reagents. , Read complete report ...
(Date:7/30/2014)... Yuma Regional Cancer Center Officially ... brings comprehensive cancer care to Yuma, Arizona. , ... Center has officially opened. A Mayo Clinic Care ... such as open, semi-private and private infusion rooms, ... Resource Center, hematology, rehabilitation center, a pain management ...
(Date:7/30/2014)... July 30, 2014   Epic Sciences, Inc. ... novel diagnostics to personalize and advance the treatment and ... Gregory T. Lucier as chairman of Epic,s board ... of Life Technologies (formerly Invitrogen). Mr. Lucier joins Epic,s ... its circulating rare cell analysis platform with special focus ...
(Date:7/30/2014)... 30, 2014 Connecticut Center for Advanced ... in East Hartford, Conn., was awarded a Rural Business ... a project that will determine the feasibility of implementing ... Connecticut. USDA Rural Development provided $53,000 for CCAT under ... second phase of the feasibility study in fiscal year ...
Breaking Biology Technology:China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3
... SEATTLE, July 9 Cell Therapeutics, Inc. (CTI),(Nasdaq and ... Providers Act of 2008, as passed by the U.S. ... Senate on July 9, 2008, would,continue the 2007 reimbursement ... a start date of July,1, 2008. In December, Congress ...
... Compensatory Award Will Now Proceed -, MADISON, N.J., July ... motion for judgment as a matter of law on the,punitive ... v.,Wyeth, in the U.S. District Court, Eastern District of Arkansas, ... damages award of,$19,360,000 rendered by the Little Rock jury last ...
... ARBOR, Mich., July 9 Terumo Cardiovascular Systems,(Terumo ... infringement complaint in,Germany against two affiliates of Maquet ... Vertriebs und Service Deutschland GmbH. The complaint,alleges that ... Vessel Harvesting Systems, infringe a patent for which ...
Cached Biology Technology:Congress Extends 2007 Reimbursement Rates for Radioimmunotherapies for 18 Months 2Congress Extends 2007 Reimbursement Rates for Radioimmunotherapies for 18 Months 3Congress Extends 2007 Reimbursement Rates for Radioimmunotherapies for 18 Months 4Wyeth's Motion to Overturn Punitive Damages Award Granted by Arkansas Court 2Wyeth's Motion to Overturn Punitive Damages Award Granted by Arkansas Court 3Terumo Cardiovascular Systems Files Patent Infringement Complaint Against Maquet Affiliates 2
(Date:7/30/2014)... HIV infection could be as simple as inserting a ... University of Washington bioengineers have discovered a potentially faster ... from contracting HIV. Their method spins the drug into ... moisture, releasing higher doses of the drug than possible ... , "This could offer women a potentially more effective, ...
(Date:7/30/2014)... humans figured out how to create colors, nature had ... wings of many different hues, for example. Now scientists ... environmentally friendly way to make colored plastics. Their paper ... of materials rather than dyes, to produce color ... , N. Asger Mortensen, Anders Kristensen and colleagues point ...
(Date:7/30/2014)... been awarded the Scientific Committee on Antarctic Research,s ... , SCAR, an inter-disciplinary international science body, initiates, ... in the Antarctic region, and on the role ... The organisation also provides scientific advice about Antarctica ... the region. , The medal is open internationally ...
Breaking Biology News(10 mins):Dissolvable fabric loaded with medicine might offer faster protection against HIV 2Dissolvable fabric loaded with medicine might offer faster protection against HIV 3
... The Scripps Research Institute has been awarded a $500,000 ... pair of genetic mutations that could lead to a new ... and fatal neurodegenerative disorder. Philip LoGrasso, PhD, a professor ... Scripps Florida, is the principal investigator for the project. ...
... DeKalb, Ill. -- It,s safe to say Northern Illinois ... cats. She keeps two tabbies at her Hampshire, Ill. home. ... anything but cute and cuddly -- the prehistoric saber-tooths. ... of Kansas and fossil hunter John Babiarz -- are editors ...
... warming and its impact on our environment have left ... humans produce. Now, Tel Aviv University researchers are doing ... growing forests in the most unlikely place deep ... such as a local plant species, recycled sewage water ...
Cached Biology News:Scripps Research scientist awarded $500,000 grant to study Parkinson's disease 2Scripps Research scientist awarded $500,000 grant to study Parkinson's disease 3NIU biologist Virginia Naples is helping put new face on ferocious saber-tooth cats 2NIU biologist Virginia Naples is helping put new face on ferocious saber-tooth cats 3Growing something out of nothing 2
RECOMBINANT EQUINE TNF ALPHA Product Type: Recombinant Protein...
... contains 5 ml of DETACHaBEAD 19 ... Dynabeads CD19 (Pan B). B ... B) and released with DETACHaBEAD CD19 ... are suitable for applications such as ...
... Buffers are supplied as 10X concentrated solutions. REact ... each of the REact buffers and one 250 ... of four 1 ml vials of REact 1 ... Buffer four 1 ml vials of REact 3 ...
... The Vybrant Apoptosis Assay Kit #4 ... changes that occur in the permeability of ... of both YO-PRO-1 and propidium iodide nucleic ... the plasma membranes of apoptotic cells and ...
Biology Products: