Navigation Links
Study dusts sugar coating off little-known regulation in cells
Date:4/16/2012

RICHLAND, Wash. -- In Alzheimer's disease, brain neurons become clogged with tangled proteins. Scientists suspect these tangles arise partly due to malfunctions in a little-known regulatory system within cells. Now, researchers have dramatically increased what they know about this particular regulatory system in mice. Such information will help scientists better understand Alzheimer's and other diseases in humans and could eventually provide new targets for therapies.

In a study released online in the Proceedings of the National Academy of Sciences Early Edition this week, the team at least doubled the number of proteins found to be subject to a type of regulation based on a sugar known as O-GlcNAc (oh-GLIK-nak). The O-GlcNAc system likely adds another layer of control to the proteins that serve as a brain cell's widgets and gears -- control that might be muddled in Alzheimer's brains known to have problems in sugar metabolism.

"We found many novel proteins providing insights into new aspects of cell biology," said analytical biochemist Feng Yang of the Department of Energy's Pacific Northwest National Laboratory and lead author on the study. "We think O-GlcNAc is fine-tuning cellular processes."

In addition to finding hundreds of proteins modified by O-GlcNAc, the team found that almost all the O-GlcNAc proteins were also subject to the most common form of protein regulation, which uses small phosphate molecules to turn proteins on and off. This suggests a larger coordination between the two regulatory systems.

"These results show there's a level of complexity about how biology operates that we've been largely blind to," said PNNL's Richard D. Smith, who leads the proteomics team at PNNL. Proteomics researchers try to understand how a cell functions based on the numbers and types of its proteins at work, which are collectively known as the proteome (PRO-tee-ohm).

"Back during the Human Genome Project, we aske
'/>"/>

Contact: Mary Beckman
mary.beckman@pnnl.gov
509-375-3688
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. Urologists Debunk Misleading, Grossly Inaccurate Prostate Cancer Biopsy Study
2. Syndax Pharmaceuticals Announces Start of Phase 1/2 Study of Entinostat in Combination with Lapatinib in HER2-Positive Metastatic Breast Cancer
3. Expanded Findings for FirstMarks Completed Clinical Study for Predicting Near-Term (2-3 Years) MI
4. CNIO researchers take part in the most comprehensive personalized medicine study performed to date
5. CSL Behring Study Confirms Early Treatment with Berinert® Provides Faster Resolution of Acute Hereditary Angioedema Symptoms
6. FirstMarks Landmark Clinical Study Successfully Completed that Fulfills the Unmet Need to Access the Risk of Near Term MI
7. New Study Building Framework to Bring Personalized Medicine to the Clinic
8. Argos Therapeutic Arcelis™ Immunotherapy AGS-003 in Combination With Sunitinib Shows Statistically Significant Correlation of Immune System Response to Overall Survival in Phase 2 Study in Patients with Advanced Renal Cell Carcinoma (RCC)
9. Nature Materials study: Graphene invisible to water
10. Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process
11. Genomic Health Presents Results From First Clinical Decision Making Study of Oncotype DX® Colon Cancer at the 2012 Gastrointestinal Cancers Symposium
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) has ... Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... traces its roots in the latter half of ... went unexplored and unfulfilled for several decades owing ...
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
(Date:7/10/2014)... Understanding the basis of psychiatric disorders has been extremely ... increase risk but are insufficient to cause disease. Now ... Cell Press journal Cell Stem Cell describe ... genetic risks interact with other risk factors or environmental ... Their research pinpoints a genetic variant that may predispose ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Detecting trace amounts of explosives with light 2New strategy could uncover genes at the root of psychiatric illnesses 2Even geckos can lose their grip 2
... its Fiscal Year 2009" issued on 15 Mar,2010 13:20 GMT , by Health Robotics over PR Newswire, we are ... Complete, corrected release follows: , ... , ... ...
... radionuclide - , ... ... - Interaction of ... , ...
... and OXFORD, England , March ... PharmaVentures Limited ("PharmaVentures"),today announced the signing of a ... biotech, pharmaceutical and med tech sectors.,The companies will ... consolidation opportunities which bring together both strategic,expertise and ...
Cached Biology Technology:/C O R R E C T I O N -- Health Robotics/ 2/C O R R E C T I O N -- Health Robotics/ 3/C O R R E C T I O N -- Health Robotics/ 4/C O R R E C T I O N -- Health Robotics/ 5/C O R R E C T I O N -- Health Robotics/ 6/C O R R E C T I O N -- Health Robotics/ 7/C O R R E C T I O N -- Health Robotics/ 8/C O R R E C T I O N -- Health Robotics/ 9/C O R R E C T I O N -- Health Robotics/ 10/C O R R E C T I O N -- Health Robotics/ 11/C O R R E C T I O N -- Health Robotics/ 12/C O R R E C T I O N -- Health Robotics/ 13/C O R R E C T I O N -- Health Robotics/ 14/C O R R E C T I O N -- Health Robotics/ 15/C O R R E C T I O N -- Health Robotics/ 16/C O R R E C T I O N -- Health Robotics/ 17YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations 2YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations 3YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations 4YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations 5YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations 6YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations 7Matrix Corporate Capital and PharmaVentures Announce the Signing of a Memorandum of Understanding (MOU) 2Matrix Corporate Capital and PharmaVentures Announce the Signing of a Memorandum of Understanding (MOU) 3Matrix Corporate Capital and PharmaVentures Announce the Signing of a Memorandum of Understanding (MOU) 4
(Date:7/10/2014)... In Santa Fe, Albuquerque, and other major cities in ... watered with treated municipal wastewater rather than precious potable ... more than 40% of all golf courses receive treated ... courses. , Additionally, golf courses and homeowners alike ... nutrient in fertilizer is nitrate. A New Mexico State ...
(Date:7/10/2014)... , July 1, 2014 Smart technology ... for convenience and improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay ... GOOG ), Apple Inc. (NASDAQ: AAPL ), ... (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication ... announce that the second series of 30 second spots on ...
(Date:7/10/2014)... According to the new market research report, ... (Optical Prism, Pizeoelectric, Capacitive, and Adhesives), Application (Mobile Devices, ... and Geography - Global Trends & Forecasts to 2014 ... Market is projected to cross $14.35 Billion by 2020, ... to 2020. Browse more than 78 market ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3
... A team composed of Harvard students and alumni ... Africa 2008 Development Marketplace competition, held in Accra, Ghana ... fuel cell-based lighting systems suitable for Sub-Saharan Africa, netted ... World Bank, as only 26 percent of Africas population ...
... ARBOR, Mich.---The mouse is a stalwart stand-in for humans ... percent identical. But identical genes may behave differently in ... evolutionary biologists Ben-Yang Liao and Jianzhi Zhang reveals. ... mouse models in studying human disease, appear in the ...
... Japanese researchers have found a strong link between tooth ... head and neck, and lung. They suggest that preservation ... In the May issue of Cancer Epidemiology, Biomarkers ... Cancer Research, scientists from Aichi Cancer Center in Nagoya ...
Cached Biology News:Undergraduates develop 'dirt-powered' microbial fuel cells to light Africa 2Undergraduates develop 'dirt-powered' microbial fuel cells to light Africa 3Mouse can do without man's most treasured genes 2Mouse can do without man's most treasured genes 3Tooth loss strongly linked to risk of esophageal, head and neck, and lung cancer 2
Gastric Carcinoma Marker [BY-1 (3H11)]...
Human Dectin-1/CLEC7A Biotinylated Affinity Purified PAb...
Recognizes Kir4.1. The epitope does not share homology with any other known proteins.,SPECIES REACTIVITIES: The antibody is also expected to work with mouse and human due to sequence homology. Oth...
Profilin-1/2 (FL-140)...
Biology Products: