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Study Suggests GAMMAGARD LIQUID May Target the Primary Pathway Involved in Alzheimer's Disease
Date:4/15/2008

ause Alzheimer's disease," said Dr. O'Nuallain. "These initial findings could be promising in Alzheimer's disease research using naturally occurring antibodies."

The oral presentation at AAN, entitled "Affinity Isolation and Characterization of Abeta Conformer-Reactive Antibodies Contained in Human Immune Globulin (IVIG)," showed that GAMMAGARD contains naturally occurring antibodies that directly bind to different forms of beta-amyloid protein, including oligomers and fibrils.

"Observations from this study provide insight into how GAMMAGARD LIQUID may be of potential clinical benefit for Alzheimer's patients," said Dave Morgan, director of Neuroscience Research, University of South Florida. "This study suggests that GAMMAGARD LIQUID may target the primary pathway involved in Alzheimer's disease and justifies additional studies to evaluate whether GAMMAGARD LIQUID can effectively reverse the effects of Alzheimer's disease."

According to the Alzheimer's Association, an estimated 5.2 million Americans have Alzheimer's disease, including one out of eight people age 65 and older, and the number of new cases per year is expected to grow to 454,000 by 2010. No cure currently exists that can halt or delay the brain deterioration associated with Alzheimer's disease, but new research shows encouraging results. The study's findings showed how the mechanism of action of GAMMAGARD may work on multiple forms of the beta-amyloid peptide to protect the human brain from dementia and may facilitate the development of treatment for patients with Alzheimer's disease.

Additional GAMMAGARD Trials in Alzheimer's Disease

At the AAN meeting, other studies will be presented on the use of GAMMAGARD in Alzheimer's disease. One oral presentation scheduled for April 17 - "A Double-Blind, Placebo-Controlled, Phase II Clinical Trial of Intravenous Immunoglobulin (IVIG) for Treatment of Alzheimer's Disease" - will discuss the evaluation of the efficacy, tolerabil
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SOURCE Baxter International Inc.
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