Study Reaffirms Superiority of Trofile...( Pfizer Study Finds Pathway's SensiTro...)

Pfizer Study Finds Pathway's SensiTrop(TM) Assay Is Discordant in Detecting

HIV Tropism with Clinically Validated Trofile

SOUTH SAN FRANCISCO, Calif., Dec. 19 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM) today announced that Pfizer Inc (NYSE: PFE), the manufacturer of Selzentry(TM) (maraviroc), has reported the results of a study that compares Monogram's Trofile Assay and Pathway Diagnostics' SensiTrop Assay. Pfizer concluded, based on study results, that the SensiTrop results were discordant with the results obtained using Trofile, which was used and clinically validated in the Selzentry clinical trials.

In the study of 100 patient samples, of the 39 samples previously identified as dual/mixed (D/M) or X4-tropic by Trofile, 19 were classified as R5-tropic by SensiTrop. "This is of paramount importance," said William Young, Monogram's chief executive officer. In its release, Pfizer commented "these findings mean that there is a possibility that some patients whose tropism was assessed with SensiTrop may have received Selzentry based on an inaccurate R5 tropism reading. Selzentry is only indicated for use in treatment-experienced patients infected with R5-tropic HIV-1. If Selzentry is selected as an active drug for patients infected with D/M or X4-tropic HIV, it may not contribute to virologic suppression and could result in emergence of resistance to other drugs in the treatment regimen."

"We are delighted Pfizer undertook this comparative analysis with Trofile, which is the only clinically validated tropism assay," continued Young. "At Monogram, we believe strongly that scientific data should drive products and their use by physicians. All of our products are founded on science tha
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