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Study Published in World Journal of Gastroenterology Shows Potential for microRNAs to Predict Gastric Cancer Recurrence
Date:11/4/2011

uthor of the study, said, "The results of this study showed that three microRNAs may indeed serve as biomarkers for the risk of recurrence of gastric cancer after resection, and add to the accumulating data on the prognostic role of microRNAs in gastric cancer."

"Another strong point of this study is that it provides meaningful predictive values, which may have important implications for patient care. Informed decision-making using a test with a high positive predictive value can spare patients unnecessary and sometimes toxic post-surgery treatment.  We were able to identify a group of samples with low signals of miR-451 for which the positive predictive value for non-recurrence was 100%.  Thus, our finding, if validated, suggests that those with low miR-451 expression do not require adjuvant therapy because their risk of recurrence is low," concluded Dr. Brenner.  

"With nearly one million new cases of gastric cancer worldwide each year and a high incidence of recurrence, an accurate prognostic biomarker signature would be of significant value as clinicians currently rely on the staging of disease as the primary predictor.  This study underscores the need for better selection of patients for various treatment strategies as patients with a good prognosis may be spared potentially toxic adjuvant chemotherapy and radiation, and those with a poor prognosis may receive such treatment or even be offered investigational treatment programs," noted Kenneth A. Berlin, President and Chief Executive Officer of Rosetta Genomics. "This study further supports the role of microRNAs as important biomarkers and further validates the strength of Rosetta's microRNA discovery and development platform."  

About Gastric CancerGastric cancer is a highly aggressive and lethal malignancy. It accounts for 8.6% of all new cancer cases worldwide and is the second leading cause of cancer deaths. Of the estimated 930,000 people newly diagnosed wit
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