Navigation Links
Study Published in World Journal of Gastroenterology Shows Potential for microRNAs to Predict Gastric Cancer Recurrence
Date:11/4/2011

PHILADELPHIA and REHOVOT, Israel, Nov. 4, 2011 /PRNewswire/ -- Rosetta Genomics, Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces that results from a joint study by researchers at the Institutes of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Hospital and Golda-Hasharon Hospital in Petach-Tikva, Israel show that in post-resection gastric cancer patients microRNAs may serve to predict the risk of recurrence.

The study, entitled "microRNAs as a potential prognostic factor in gastric cancer," was published online September 21, 2011, and is set to appear in the print edition of the World Journal of Gastroenterology.   The abstract of the study can be viewed online at: http://www.ncbi.nlm.nih.gov/pubmed/22046085.

This retrospective study compared microRNA profiles in surgically resected primary gastric cancer tumors between patients with and without recurrence in order to evaluate their prognostic impact.  

Key Findings

  • Three microRNAs were found to be differentially expressed in tumors from patients with good prognosis versus patients with bad prognosis, namely miR-451 (p<0.0002), miR-199a-3p (p<0.0027) and miR-195 (p<0.0046).
  • High expression of each of these three microRNAs was associated with poorer prognosis for both recurrence and survival.
  • Using miR-451, the positive predictive value for non-recurrence was 100% (13/13).
  • The expression of differential microRNAs was verified by qRT-PCR, showing high correlation to microarrays and similar separation into prognosis groups.

  • Commenting on the clinical utility for such a potential microRNA prognostic, Baruch Brenner, M.D., Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Hospital and the lead a
    '/>"/>

    SOURCE Rosetta Genomics
    Copyright©2010 PR Newswire.
    All rights reserved

    Page: 1 2 3 4 5 6

    Related biology technology :

    1. Jennerex to Present Final Survival Data From Randomized Phase 2 Clinical Trial of JX-594 in Advanced Liver Cancer at American Association for the Study of Liver Diseases Annual Meeting
    2. Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells
    3. CU-Boulder python study may have implications for human heart health
    4. Study offers clues as to why some patients get infections from cardiac implants
    5. Study Hints at Possible Therapeutic Strategy to Combat Premature Birth
    6. Revolutionary IVF Study May Change the Way Embryos are Biopsied for Genetic Disease
    7. EORTC, BIG, and Agendia Announce Completion of Patient Recruitment for International MINDACT Study
    8. HABIT Study Highlights Home BNP Testing May Allow for Earlier Interventions and Better Management of Heart Failure Patient
    9. International Study Confirms CNSystems-Technology
    10. Childrens Oncology Group and Apeiron to Jointly Conduct Phase II Study in Neuroblastoma With hu14.18-IL2 (APN301)
    11. Otonomy Presents Positive New Findings From Phase 1b Study of OTO-104 in Menieres Disease at International Conference
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:1/15/2014)... 2014 Look inside the new Preferred ... the lab, from fluid handling to instruments to supplies. ... when you order. , Preferred Solutions features a ... the L/S® model for precise flow control and dispensing ...
    (Date:1/15/2014)... 15, 2014 ­ RedBrick Health , a fast-growing ... today announces that EmblemHealth , the ... is now providing the RedBrick Compass health assessment, combined ... all of its members. EmblemHealth is among the first ...
    (Date:1/15/2014)... (PRWEB) January 15, 2014 More than ... and about 1 in 3 seniors will die with ... ). These jaw-dropping figures have shocked many Americans into ... hopefully, help prevent these tragic age-related cognitive disorders. Jonathan ...
    (Date:1/15/2014)... DTS Language Services, Inc . is ... for Life Science organizations who need document translations. Clients ... of their documents in advance with a selection of nearly ... translations, often a critical factor in clinical and scientific fields, ...
    Breaking Biology Technology:Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2
    ... GENEVA, SWITZERLAND , May 4 /PRNewswire-FirstCall/ - Anavex Life ... from animal studies with ANAVEX 2-73, the company,s lead compound for ... , , ... a new class of drugs that target mitochondrial dysfunction thought to ...
    ... Symbol: MS , , ... EDMONTON, AB , May 3 ... updated corporate strategy. The Company,s new strategy will encompass becoming ... will directly invest in and advise companies on strategy, financing, ...
    ... BERLIN and CHICAGO ... become one of the most important biotechnology segments in ... EUR 2 billion German diagnostics,market, the segment enjoys a ... driven by industry trends toward personalized,medicine that are correspondingly increasing ...
    Cached Biology Technology:Anavex reports animal study results as lead Alzheimer's compound approaches phase 1 clinical trials 2Anavex reports animal study results as lead Alzheimer's compound approaches phase 1 clinical trials 3Anavex reports animal study results as lead Alzheimer's compound approaches phase 1 clinical trials 4Anavex reports animal study results as lead Alzheimer's compound approaches phase 1 clinical trials 5BioMS updates corporate strategy and adds leading healthcare investment banker 2BioMS updates corporate strategy and adds leading healthcare investment banker 3BIO 2010: German Molecular Diagnostics Segment Posting Double-Digit Growth 2BIO 2010: German Molecular Diagnostics Segment Posting Double-Digit Growth 3
    (Date:4/17/2014)... KAN. A Kansas State University engineer has ... and remotely detects improvised explosive devices. The same ... William Dunn, the Steven M. and Kay L. ... mechanical and nuclear engineering, and his research team ... hidden underground or in car trunks. The distance ...
    (Date:4/17/2014)... Europe, Asia and the United States are spreading across ... native honeybee populations at this time, according to an ... Nosema microsporidia and Varroa mites., ... these invasive pests, which suggests to us that the ... the United States currently are not necessary in East ...
    (Date:4/17/2014)... Cell Press journal Current Biology on April ... sex lives. The Brazilian insects, which represent four distinct ... are the first example of an animal with sex-reversed ... in several different animals, Neotrogla is the ... reversed," says Kazunori Yoshizawa from Hokkaido University in Japan. ...
    Breaking Biology News(10 mins):Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3In sex-reversed cave insects, females have the penises 2
    ... afflict as many as 12 million people worldwide relies on ... compounds developed to treat cancer and other disorders, researchers at ... Scientists searched the genome of the parasite Leishmania ... kinases, proteins that are linked to cell growth and cancer ...
    ... scientist Agnieszka Bialek won the Royal Photographic Society,s Selwyn Award ... The Selwyn Award is sponsored by Imaging Science Group of ... memory of E W H Selwyn, an eminent photographic scientist. ... the age of 35 who has conducted successful science based ...
    ... under Ralf Sommer,s microscope: his research object, the roundworm ... in its side and devours the oozing contents. The squirming ... Caenorhabditis elegans may be a close relative of ... strong "teeth". Pristionchus , impressive hunting technique though is ...
    Cached Biology News:Cancer drugs may help stop major parasite 2National Physical Laboratory scientist wins photographic award 2A worm bites off enough to chew 2
    ... The MasterPure™ Plant Leaf DNA Purification Kit is ... fresh plant leaf tissue. The protocol can be ... be scaled up to obtain larger amounts of ... PCR amplification, restriction digestion, and Southern blotting. The ...
    ...
    ...
    Sf9 Insect Cells (Frozen) in Max-XP Medium...
    Biology Products: