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Study Published in World Journal of Gastroenterology Shows Potential for microRNAs to Predict Gastric Cancer Recurrence
Date:11/4/2011

PHILADELPHIA and REHOVOT, Israel, Nov. 4, 2011 /PRNewswire/ -- Rosetta Genomics, Ltd. (NASDAQ: ROSG), a leading developer and provider of microRNA-based molecular diagnostics, announces that results from a joint study by researchers at the Institutes of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Hospital and Golda-Hasharon Hospital in Petach-Tikva, Israel show that in post-resection gastric cancer patients microRNAs may serve to predict the risk of recurrence.

The study, entitled "microRNAs as a potential prognostic factor in gastric cancer," was published online September 21, 2011, and is set to appear in the print edition of the World Journal of Gastroenterology.   The abstract of the study can be viewed online at: http://www.ncbi.nlm.nih.gov/pubmed/22046085.

This retrospective study compared microRNA profiles in surgically resected primary gastric cancer tumors between patients with and without recurrence in order to evaluate their prognostic impact.  

Key Findings

  • Three microRNAs were found to be differentially expressed in tumors from patients with good prognosis versus patients with bad prognosis, namely miR-451 (p<0.0002), miR-199a-3p (p<0.0027) and miR-195 (p<0.0046).
  • High expression of each of these three microRNAs was associated with poorer prognosis for both recurrence and survival.
  • Using miR-451, the positive predictive value for non-recurrence was 100% (13/13).
  • The expression of differential microRNAs was verified by qRT-PCR, showing high correlation to microarrays and similar separation into prognosis groups.

  • Commenting on the clinical utility for such a potential microRNA prognostic, Baruch Brenner, M.D., Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Hospital and the lead a
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