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Study Published in Clinical Cancer Research Confirms Potential Of Peregrine's Bavituximab Combined With Radiation In Lung Cancer
Date:9/4/2007

n future clinical studies."

Peregrine completed a pilot Phase I study evaluating bavituximab in combination with chemotherapy in advanced cancer patients earlier this year and reported promising results. Based on these results, Peregrine recently submitted a Phase II clinical protocol to test bavituximab plus carboplatin/paclitaxel in lung cancer patients and plans to file several additional combination therapy clinical protocols this year.

Lung cancer is the leading cause of cancer deaths in the U.S. with a 5-year survival rate of only about 15%. With more than one million new cases diagnosed worldwide each year, lung cancer is also the leading cause of cancer deaths globally. About half of all lung cancer patients receive radiation therapy, but many become resistant to its tumor-killing effects. In this study, researchers tested a bavituximab equivalent combined with radiation therapy in a radiation-resistant mouse model of lung cancer.

The UT Southwestern Medical Center researchers found that in this lung cancer model, radiation therapy increased by over six-fold the percentage of tumor blood vessel cells that exposed bavituximab's PS target on the external surfaces. As a result, more of the bavituximab equivalent antibodies became concentrated in the tumor blood vessels. This increased localization may have contributed to the finding that the density of tumor blood vessels was reduced by more than 90% and tumor growth was reduced by 80% in animals treated with combination therapy, significantly greater efficacy than was achieved with either treatment alone.

"Approximately 50% of all cancer patients receive radiation therapy, so these findings could potentially apply to millions of patients," noted Dr. Philip Thorpe, professor of pharmacology at UT Southwestern and a member of Peregrine's Scientific Resource Board. "We are also pleased that these results confirm our previous work that demonstrated that the enhanced therapeutic effects of b
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SOURCE Peregrine Pharmaceuticals, Inc.
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