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Study Published in Clinical Cancer Research Confirms Potential Of Peregrine's Bavituximab Combined With Radiation In Lung Cancer
Date:9/4/2007

- Bavituximab Equivalent Combined With Radiation Reduced Tumor Growth by

80% in Preclinical Lung Cancer Model - - Findings Confirm Key Aspects of Bavituximab's Mechanism of Action in

Combination with Radiation Therapy - - Results Further Support Future Clinical Trials Testing Bavituximab in

Combination With Radiation Therapy -

TUSTIN, Calif., Sept. 4 /PRNewswire-FirstCall/ -- Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM), a clinical stage biopharmaceutical company developing targeted monoclonal antibodies for the treatment of cancer and hepatitis C virus infection, today reported that researchers have published a new study in a lung cancer model showing that the combination of a mouse equivalent of bavituximab and radiation is significantly more effective in reducing tumor growth than either therapy alone. The study was published in the September 1 issue of Clinical Cancer Research. Bavituximab, Peregrine's lead anti-phosphatidylserine (anti-PS) immunotherapy, is currently in clinical trials for the treatment of solid tumors including lung cancer.

"This new publication further supports the concept that radiation therapy and bavituximab may work synergistically to treat solid tumors." said Steven W. King, president and CEO of Peregrine. "We are particularly pleased to see these positive results in a model of radiation resistant lung cancer, by far the leading cause of U.S. cancer deaths. This is the latest in a series of preclinical studies that have demonstrated the potential of either radiation or chemotherapy to enhance bavituximab's anti-tumor effects. We look forward to evaluating a combination of bavituximab plus radiation therapy i
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SOURCE Peregrine Pharmaceuticals, Inc.
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