Navigation Links
Study Links Biomechanics and Gene Expression in Stem Cells

Waterloo, ON (PRWEB) August 01, 2014

Testing the mechanical properties of microtissues by researchers has led to a better understanding embryonic development. How and why embryonic stem cells differentiate and reorganize into structurally and functionally distinct tissues is important because abnormalities can lead to devastating physical defects. Prof. Todd McDevitt, Melissa Kinney, and Rabbia Saeed worked from the premise that biophysical signals interact with biochemical cues to control many aspects of embryo development. In their recent study published in Nature Scientific Reports (, the team assessed the mechanical changes in 3D stem cell microtissues and linked these changes with cell differentiation and tissue morphology changes.

The team used the CellScale MicroSquisher ( to perform mechanical testing of the 3D tissues, which were 200-500µm in size. The unique ability of the MicroSquisher to resolve small forces was critical for this application, where the peak forces were less than 20µN.

This data will enable a better understanding of embryonic development, which is critical developing strategies to prevent many birth defects. The data will also enable the development of new approaches to direct the differentiation and patterning of 3D microtissues for further research in drug development and tissue repair.

CellScale is an industry leader in providing researchers with precision biomaterial and mechanobiology test systems. Currently, you can find our products being used by world class academic and commercial organizations across the globe.

Our mechanical test systems are specifically designed for analyzing and characterizing the material properties of natural and artificial biomaterials.

Our mechanobiology technology helps advance research by providing insights into the response of cells to mechanical stimulation – a key factor in the pursuit of the next revolution in medical treatments.

Caleb Horst, Director of Business Development
CellScale Biomaterials Testing

Read the full story at

Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related biology technology :

1. Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant
2. Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference
3. RXi Pharmaceuticals Expands Clinical Program with Initiation of Third Phase 2a Study with RXI-109 for Treatment of Hypertrophic Scars
4. Zerenex (ferric citrate) long-term Phase 3 study results published in JASN
5. ORNL study reveals new characteristics of complex oxide surfaces
6. National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS
7. StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study
8. Syracuse University chemist to use NSF grant to study materials chemistry, nanoscience
9. Resolve Initiates Phase 2 Clinical Study in SLE
10. Research Study on Lithopone Industry (China, Global Regions) Development Trends Available at
11. Worcester Polytechnic Institute Receives NIH Grant to Study Components of a Potentially Potent and Cost-Effective Malaria Treatment
Post Your Comments:
(Date:11/30/2015)... Jose, CA (PRWEB) , ... ... ... Content Intelligence Company, today announced tighter software integration with MarkLogic, the Enterprise ... where organizations maximize information to drive change. , Smartlogic’s Content Intelligence capabilities ...
(Date:11/27/2015)... ... 27, 2015 , ... Pittcon is pleased to announce the ... in symposia, oral sessions, workshops, awards, and posters. The core of the ... such as, but not limited to, biotechnology, biomedical, drug discovery, environmental, food science, ...
(Date:11/25/2015)... 2015 --> ... - 2020 report analyzes that automating biobanking workflow ... in long-term samples, minimizing manual errors, improving the ... manual errors such as mislabeling or inaccurate sample ... plays a vital role in blood fractionation, DNA ...
(Date:11/25/2015)... HOLLISTON, Mass. , Nov. 25, 2015 ... a biotechnology company developing bioengineered organ implants for life-threatening ... will present at the LD Micro "Main Event" investor ... PT. The presentation will be webcast live and posted ... also be available at the conference for one-on-one meetings ...
Breaking Biology Technology:
(Date:11/10/2015)... Nov. 10, 2015  In this report, ... basis of product, type, application, disease indication, ... this report are consumables, services, software. The ... safety biomarkers, efficacy biomarkers, and validation biomarkers. ... are diagnostics development, drug discovery and development, ...
(Date:11/2/2015)... , Nov. 2, 2015  SRI International has ... to provide preclinical development services to the National Cancer ... SRI will provide scientific expertise, modern testing and support ... of preclinical pharmacology and toxicology studies to evaluate potential ... --> The PREVENT Cancer Drug Development Program is ...
(Date:10/29/2015)... 2015  Connected health pioneer, Joseph C. Kvedar ... technology-enabled health and wellness, and the business opportunities that ... The Internet of Healthy Things . Long before ... existed, Dr. Kvedar, vice president, Connected Health, Partners HealthCare, ... moving care from the hospital or doctor,s office into ...
Breaking Biology News(10 mins):