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Study Finds Noninvasive Blood Test for Liver Fibrosis May Alleviate Need for Liver Biopsies for Some Patients with Chronic Hepatitis C
Date:6/8/2009

olunteers. The diagnostic performance score for Hepascore by AUROC(1) was 0.81 for significant fibrosis, 0.83 for advanced fibrosis, and 0.88 for cirrhosis.

"While Hepascore is unlikely to entirely replace liver biopsy as a staging test for liver fibrosis, our findings demonstrate the potential value of a Hepascore-based algorithm in managing chronic HCV patients," said Wael A. Salameh, M.D., study investigator and medical director, endocrinology, Quest Diagnostics Nichols Institute. "For a Hepascore value less than or equal to 0.2, significant fibrosis is unlikely and continued observation on an annual basis is sufficient. For individuals with a Hepascore equal to or greater than 0.8 with elevated FIB-4 or APRI values, therapy and cancer screening should be strongly considered."

The study is titled "Validation of Hepascore, Compared With Simple Indices of Fibrosis, in Patients With Chronic Hepatitis C Virus Infection in United States." Beth Israel Deaconess Medical Center and Quest Diagnostics Nichols Institute, the esoteric research and development testing center of Quest Diagnostics, implemented the study. Quest Diagnostics funded the study. Dr. Afdhal is a consultant who has received grant support from Quest Diagnostics.

{Visit http://www.elsevier.com/locate/cgh for more information on Clinical Gastroenterology and Hepatology, published by Elsevier. Members of the media may request copies of the publication by emailing Elsevier at newsroom@elsevier.com.}

Quest Diagnostics is a leader in noninvasive blood-based biomarker testing used by physicians to screen for, diagnose and monitor carcinomas and other tissue-based dise
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SOURCE Quest Diagnostics Incorporated
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