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Study Finds BYETTA(R) Use Was Not Associated With Increased Rate of Acute Pancreatitis Compared to Other Antidiabetic Drugs: Final Results Presented at ADA 2010
Date:6/26/2010

antidiabetes therapies,"(i) said Orville G. Kolterman, M.D., senior vice president, chief medical officer, Amylin Pharmaceuticals. "The study suggested that cases of pancreatitis in past BYETTA users may be related to other risk factors, such as gall stones, past acute pancreatitis and obesity."

Amylin and Lilly are continuing work to better understand the relationship between BYETTA and pancreatitis described in some spontaneously reported cases. In keeping with the companies' focus on patient safety, Amylin and Lilly continue to pursue a drug safety program that includes thorough investigation of individual spontaneous case reports along with clinical and epidemiologic studies. Patients and healthcare professionals should refer to product labeling for guidance regarding the use of BYETTA.

Study Design and Findings

Eligible patients were enrolled in the healthcare plan for at least a continuous nine-month baseline period with no history of chronic or acute pancreatitis prior to initiation of a new antidiabetic therapy. Adjudication of 652 claims-identified acute pancreatitis cases resulted in 40 confirmed acute pancreatitis cases in the BYETTA initiators and 254 confirmed cases in the other antidiabetic drug initiators. The NCCS analysis incorporated covariates (claims- and chart-derived) temporally related to acute pancreatitis occurrence to account for differences in the prevalence of risk factors between patients who persisted on or discontinued the study drugs.  

About Diabetes

Diabetes affects more than 24 million people in the U.S. and an estimated 285 million adults worldwide.(ii,iii) Approximately 90-95 percent of those affected have type 2 diabetes. Diabetes is the fifth leading cause of death by disease in the U.S. and costs approximately '/>"/>

SOURCE Amylin Pharmaceuticals, Inc.
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