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Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients
Date:3/31/2008

with an inhaled antibiotic followed by a 28 day drug holiday or "off period." This on/off cycle is often repeated multiple times and patients are surviving longer as a result. However, the commercially available treatments are not designed to penetrate the patient mucus and biofilm, have limited exposure time, and are not able to kill some of the Pseudomonas bacteria protected by the biofilm. The remaining bacteria quickly reproduce during the off treatment period to pretreatment levels and may be more resistant to further antibiotic treatment. This cycle leaves CF patients in a chronic state of infection and can cause further development of hyper-mutated or mucoidal strains of Pseudomonas. Respiratory exacerbations, loss of lung function and death can result.

The study was authored by Drs. Paul Meers and Walter Perkins of Transave Inc., and their colleagues, in collaboration with Garth James, Ph.D., and Steven Fisher, Ph.D., of the Center for Biofilm Engineering at Montana State University. The publication is currently available on the journal's website (http://jac.oxfordjournals.org/cgi/content/abstract/61/4/859).

The Cystic Fibrosis Foundation provided a $1.7 million award for the clinical program. The Cystic Fibrosis Foundation is the leading organization devoted to curing and controlling cystic fibrosis.

About ARIKACE (liposomal amikacin for inhalation)

ARIKACE is a form of the antibiotic amikacin that is enclosed in nanocapsules of lipid called liposomes. This proprietary next-generation liposomal technology prolongs release of amikacin in the lung while minimizing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 mm) neutrally charged liposomes that enable biofilm penetration and are highly efficient with very low lipid to drug ratio (0.6). ARIKACE can be effectively delivered t
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SOURCE Transave Inc.
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