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Study Confirms Anti-Infective ARIKACE(TM) Effectively Penetrates Mucus and Biofilm, and Kills Pseudomonas, a Bacteria Plaguing Cystic Fibrosis Patients
Date:3/31/2008

d lodged into the spaces within biofilms, where the antibiotic can be released very close to the bacteria.

Another important study enabled investigators to identify bacterial virulence factors secreted by Pseudomonas in the biofilm that trigger release of amikacin from the liposomes. These factors are expected to be concentrated in and near the colonies of Pseudomonas growing in the biofilm within the static mucus of CF lungs. This area is an ideal target for antibiotics and the triggered release of amikacin resulted in what was essentially Pseudomonas suicide.

"Pseudomonas is insidious in the lungs of CF patients who live with chronic infection which is why we developed a liposomal delivery technology small enough for nebulization and able to penetrate the highly-shielded biofilm," said Walter Perkins, Chief Technology Officer at Transave. "Our ultimate goal is to deliver more active antibiotic locally to the site where Pseudomonas resides in the lung, and sustain it there, while reducing the treatment burden with fewer daily doses of drug therapy."

"We know for sure that the liposomes were interacting with, and accumulating in, the biofilm," said Dr. Garth James, Ph.D., director of medical projects at the Center for Biofilm Engineering at Montana State University and a co-author of the study. Montana State University's Center for Biofilm Engineering is the world's largest and oldest biofilm research center.

"You need a drug that can penetrate biofilm in order to kill the infection. This unique drug delivery mechanism may allow that to happen," Dr. James said. "By using an advanced delivery mechanism, you can keep the drug where it needs to be for a longer period of time. A "free" drug inhaled into the lungs would likely be cleared more rapidly."

Excess mucus in the lungs of CF patients is a breeding ground for insidious Pseudomonas bacteria. CF patients with these types of infections are typically treated twice daily for 28 days
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SOURCE Transave Inc.
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