Navigation Links
Study: 'Meaningful improvements' Using Gene Therapy in Parkinson's Disease
Date:3/16/2011

DETROIT, March 16, 2011 /PRNewswire/ -- A first-of-its-kind study of gene therapy in the treatment of Parkinson's disease determined that half of all patients who received the treatment had "clinically meaningful improvements" of their symptoms within six months of surgery.

"The study demonstrates that the promise of gene therapy for neurodegenerative disorders has become a reality," says study lead author and co-principal investigator Peter LeWitt, M.D., director of movement disorders at Henry Ford Health System.

The new study is a fast-track publication in the current issue of The Lancet Neurology.

That "promise," if verified by currently ongoing follow-up studies and approved by the U.S. Food and Drug Administration, could vastly improve the lives of many of the one million Americans who now suffer the debilitating effects of Parkinson's disease.

Parkinson's disease, which usually affects people over age 50, is a progressive disorder that gradually deteriorates nerve cells in the brain. As the disorder worsens, its effects are visible in the abnormal body movements of its sufferers. These include tremors and stiffness in the arms, legs and neck; slowness of movement and coordination; and trouble with walking and balance. Dementia can develop in the late stages of the disease.

The Michigan Parkinson Foundation estimates that as many as 60,000 new cases are diagnosed each year in the U.S.

The new study, which used double-blind sham surgery controls, tested the effectiveness of a gene therapy known as NLX-P101 in 45 subjects with moderate to advanced Parkinson's disease. The patients, ages 30 to 70, were chosen because their symptoms didn't respond well to other treatments.

Among the study group, each patient was randomly selected to receive either NLX-P101 therapy or sham surgery. All of the procedures were done with local anesthesia, and most of the patients were released within 48 hours after surgery.'/>"/>

SOURCE Henry Ford Health System
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Penn study: Transforming nanowires into nano-tools using cation exchange reactions
2. Study: Medicare Covers Only Half the Cost of Administering Chemotherapy to Seniors with Cancer
3. New Study: Lp(a) Joins LDL as Heart Disease Risk Factor
4. Study: Era of Rapid Growth in Biomedical Research Over
5. American Medical Informatics Association (AMIA) Submits Comments to Hit Policy Committee About Meaningful Use and Electronic Health Record Certification
6. Healthcare Continues to Use OnBase in Meaningful Ways
7. Citius Tech Launches BI-Clinical MUSE for Advanced "Meaningful Use" Reporting and Data Submission, and Performance Management for Healthcare ISVs
8. Netsmart Technologies to Host Valuable Meaningful Use Web Seminars
9. Shengtai Pharmaceutical Completes Factory Improvements Resulting in Operational and Environmental Benefits
10. MEDRAD Partners with the University of South Florida and Moffitt Cancer Center to Study Workflow and Process Improvements in PET Imaging
11. VIVUS Announces Positive Results From Two Phase 3 Studies; Obese Patients on Qnexa Achieve Average Weight Loss up to 14.7% and Significant Improvements in Co-Morbidities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... , Aug. 28, 2014   SunTrust Robinson ... three industry veterans to its equity research team ... "Our ongoing expansion in equity research demonstrates our ... unique insights to enhance their investment decision making," ... at STRH.  "We continue to make significant investments ...
(Date:8/28/2014)... Exciting new work by a Florida State University research ... can take your temperature, emit white light, and convert ... molecule looks like a butterfly. , Biwu Ma, associate ... in the FAMU-FSU College of Engineering, created the molecule ... continued to discover that his creation has many other ...
(Date:8/28/2014)... Earlier this month, a report ... with the U.S. Air Force on the performance of ... that this type of fuel made from mustard seeds, ... important to America’s Eco friendly future. In fact, every ... to become independent of foreign oil over the next ...
(Date:8/28/2014)... 2014 Whitehouse Laboratories is excited to ... with PTI Inspection Systems that will enable ... the art leak testing method development and validation programs ... available. As part of this agreement, Whitehouse Labs has ... Detection Instrument developed and manufactured by PTI. The ...
Breaking Biology Technology:SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... 2008) Using two abundant and relatively inexpensive ... flexible webbing of nano-scale wires that multiplies surface ... wires in electronics and energy applications. , , Researchers ... two-dimensional network of branches that resemble flat, rectangular ...
... Inc.,(Nasdaq: MEDX ) announced today that it is ... at 9:10 a.m. Eastern Time on,Thursday, September 4, 2008. ... in the Investor Relations section of the Medarex website ... will be available,following the event., About Medarex, ...
... FRANCISCO, Calif., Sept. 2 Anesiva,Inc. (Nasdaq: ... has joined,the company as senior vice president and ... and regulatory functions., "Bill brings to Anesiva ... products, and a medical background in,anesthesiology," said Mr. ...
Cached Biology Technology:Scientists grow 'nanonets' able to snare added energy transfer 2Medarex to Present at the Thomas Weisel Partners Healthcare Conference 2Anesiva Announces Appointment of William Houghton, M.D. as Senior Vice President and Chief Medical Officer 2
(Date:8/29/2014)... rise of the Tibetan plateau -- the largest topographic ... for both its profound effect on climate and its ... GSA Bulletin , Katharine Huntington and colleagues employ ... using modern and fossil snail shells to investigate the ... , Views range widely on the timing of ...
(Date:8/28/2014)... in German . ... name to a striking pattern of blue stripes alternating with ... silvery cells, and yellow cells emerge during growth in the ... multilayered mosaic to compose the characteristic colour pattern. ... to interact to form proper stripes, the embryonic origin of ...
(Date:8/28/2014)... FASEB MARC (Maximizing Access to Research Careers) Program ... Genetics Society of America,s 27th Annual Mouse Molecular ... 2014 in Pacific Grove, California. These awards ... post doctorates and scientists from underrepresented groups into ... to encourage the participation of young scientists at ...
Breaking Biology News(10 mins):Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... too often, stress turns addiction recovery into relapse, but ... insight that might allow them develop a medicine to ... pinpoints the neural basis for stress-related relapse in ... accelerate progress toward a medicine that prevents stress from ...
... key role in visual and spatial processing has a parallel ... study by researchers at the University of Chicago. Primates ... stimuli into familiar and meaningful categories, such as fruit or ... locations in a scene and make spatially-targeted movements, such as ...
... In order to build and maintain cells, DNA is ... Transcripts are often like a recipe for making proteins, ... cell is called a transcriptome. Pankaj Jaiswal, Assistant ... University, Samuel Fox, a Postdoctoral Associate in Jaiswal,s laboratory, ...
Cached Biology News:Study pinpoints, prevents stress-induced drug relapse in rats 2Study pinpoints, prevents stress-induced drug relapse in rats 31 region, 2 functions: Brain cells' multitasking key to understanding overall brain function 21 region, 2 functions: Brain cells' multitasking key to understanding overall brain function 3Assembling the transcriptome of a noxious weed: New resources for studying how plants invade 2
... can perform many sophisticated DNA analysis and protein ... than just another sequence analysis product. Imagine having ... analyses to be performed each time you have ... sheets which specify exactly how your output will ...
... does for enzyme-/substrate-based blotting what intensifying screens do ... up to 10-fold (or one order of magnitude) ... Signal Enhancer membrane treatment is a simple, 15-minute ... current Western blotting protocol. The result is an ...
These stopping screens are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 screens....
...
Biology Products: