Navigation Links
Studies Assess Hydroxyurea Therapy and Pre-Operative Transfusions for Patients with Sickle Cell Disease
Date:12/11/2011

to take hydroxyurea.

Follow-Up Study I data indicate that children who continue to take hydroxyurea have statistically lower rates of pain crises requiring emergency room visits, episodic transfusions, and hospital admissions for any reason when compared to those taking placebo. These clinical benefits are similar to those demonstrated by the drug in BABY HUG, the results of which were published earlier this year and are consistent with previously published trials that detail the therapy's benefits in older children and adults.

"Our study data reveal not only that the clinical benefits of hydroxyurea continue with ongoing administration, but also the wide acceptance of the treatment by the families of our patients, demonstrated by the high percentage of families that continued their children on hydroxyurea after the randomized trial ended," said lead author Zora R. Rogers, MD, Professor of Pediatrics at UT Southwestern Medical Center Dallas and Clinical Director of the Bone Marrow Failure and General Hematology Program at Children's Medical Center Dallas. "Analysis of growth and development assessments obtained in the Follow-Up Study along with these clinical results will further enhance our understanding of the benefits of the use of starting hydroxyurea in children with sickle cell disease at a very young age."

The BABY HUG Follow-Up Study I is funded by the National Heart, Lung, and Blood Institute (NHLBI) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Dr. Rogers will present this study in an oral presentation on Sunday, December 11, at 4:30 p.m. PST at the Manchester Grand Hyatt in the Elizabeth Ballroom AB.

Genotoxicity Associated with Hydroxyurea Exposure in Infants with Sickle Cell Anemia: Results From the BABY-HUG Phase III Clinical Trial [Abstract 8]

Using data from the larg
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7

Related biology technology :

1. ICON Medical Imaging Launches New Service to Boost Reliability of Cardiology Studies
2. OpenClinica EDC Solution Deployed for Retina Implant Studies
3. Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies
4. Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools
5. NIST studies how new helium ion microscope measures up
6. Five New Clinical Studies Show Value of Masimo PVI & PI
7. ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting
8. Isolagen to Host Investor Conference Call to Present an Analysis of the Data from Phase III Wrinkle Studies
9. New Clinical Studies Presented at the American Society of Anesthesiology (ASA) Annual Meeting Show Masimo Technologies Provide Advanced Clinical Intelligence
10. Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
11. Trubion Reports Re-treatment Results Following Phase 1/2a and Phase 2b Studies Evaluating TRU-015 for Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... , May 23, 2013 BioTrends ... and advisory firms for specialized biopharmaceutical issues, finds ... and infectious disease specialists reported that in the ... (e.g., intentionally delaying treatment) in anticipation of the ... six months ago, when only 6 percent reported ...
(Date:5/23/2013)... (PRWEB) May 23, 2013 The New ... STEM industries, Black Data Processing Associates (BDPA), is hosting ... June 8, 2013. This all-day event will encourage students ... learn the ins and outs from many of the ... p.m. at the New Jersey Institute of Technology, the ...
(Date:5/23/2013)... 23, 2013 Pusan National University Yangsan ... biotherapeutics and contract research company focused on research ... announced today a publication reporting the induction of ... oncolytic and immunotherapeutic vaccinia JX-594 (pexastimogene devacirepvec; Jennerex ... in the May 15 th , 2013 issue ...
(Date:5/23/2013)... 23, 2013 Bed bugs compromised ... had already confirmed it. Meanwhile, My Cleaning Products offered complimentary ... victims fight the pests without using harmful chemical elements. ... 15, 2013, the affected building was actually a dormitory ... was said made on May 13 and bed bug presence ...
Breaking Biology Technology:The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3Black Data Processing Associates (BDPA) New Jersey Hosts 10th Annual Families in Technology Day June 8, 2013 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... 11 /PRNewswire/ - Trillium Therapeutics Inc. (TTI), a biopharmaceutical ... entered into two definitive license agreements with University Health Network ... Toronto, Ontario , granting Trillium exclusive worldwide rights to commercialize ... transplantation and cancer. , ...
... most important technological innovation during human history. This genetic ... used individuals carrying favorable gene variants for breeding purposes. ... international team led by researchers at Uppsala University has ... of the domestic chicken. The domestic chicken has ...
... ... ... , ... , , , , ...
Cached Biology Technology:Trillium expands immunology pipeline and enters stem cell field through in-licensing of two new programs 2Trillium expands immunology pipeline and enters stem cell field through in-licensing of two new programs 3Scientific breakthrough in genetic studies of animal domestication 2Toxikon Corporation Hosts Extractables and Leachables Spring Seminar 2Toxikon Corporation Hosts Extractables and Leachables Spring Seminar 3
(Date:5/24/2013)... scientists from around the world today issued a stark ... of one or two generations, the majority of the ... the handicap of severe pressure on fresh water, an ... substitute. This handicap will be self-inflicted and is, we ... chronic underlying problems led by mismanagement and sent a ...
(Date:5/23/2013)... , Automated conserved noncoding sequence ... evolution among grasses , Within the genome of ... that undergo little change in position and sequence over ... proteins. Some of these evolutionarily stable sequences, so-called conserved ... of other genes or the condensation of chromosomes, but ...
(Date:5/23/2013)... popular fruit, can be made both better-tasting and longer-lasting ... , "Working with GM tomatoes that are different to ... compound, allows us to pinpoint exactly how to breed ... John Innes Centre. , The research could also lead ... life characteristics because even higher levels of the compounds ...
Breaking Biology News(10 mins):A majority on Earth face severe self-inflicted water woes within 2 generations: Scientists 2A majority on Earth face severe self-inflicted water woes within 2 generations: Scientists 3A majority on Earth face severe self-inflicted water woes within 2 generations: Scientists 4Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3The world's favorite fruit only better-tasting and longer-lasting 2
... pinpointed a set of common variations in human DNA ... who carry them. Some of these variations are more ... future studies examining whether lupus is more prevalent among ... study. Also, the findings point to various drug ...
... is available in French . , A ... small differences between individuals at the DNA level can ... proteins. These, in turn, are responsible for the vast ... study, part of the Genome Regulators in Disease (GRID) ...
... Centre for Cancer Research at Cardiff University have made ... save the lives of women who become resistant to ... such as tamoxifen have been a huge success in ... the drugs either fail to work, or after an ...
Cached Biology News:DNA variations signal lupus risk 2DNA variations signal lupus risk 3Tiny genetic differences have huge consequences: McGill researchers 2Further breakthroughs for breast cancer patients 2
... INK4a-ARF locus encodes two unrelated proteins both ... arrests the cell cycle in a p53-dependent ... the rapid degradation of mdm2 proteinrequired for ... accumulation. This interaction is mediated by ...
... Buffer contains a precipitant to ensure that the ... dye to allow the user to follow the ... ReddyRun™: ABgene ® s proprietary mixture of ... buffer composition used in ReddyRun™ molecular weight markers. ...
Acetylcholinesterase from human and monkey....
MAb to IgG2 (Fc gamma-2) IgG2 (Fc, gamma-2 epitope)...
Biology Products: