Navigation Links
Studies Assess Hydroxyurea Therapy and Pre-Operative Transfusions for Patients with Sickle Cell Disease
Date:12/11/2011

and Efficacy of Continued Treatment -- the BABY HUG Follow-up Study [Abstract 7]

Hydroxyurea is the only federally approved therapy to prevent sickle cell complications in adults with sickle cell anemia (SCA). However, based on positive results from previous trials assessing clinical benefits for use in children, specialists are increasingly considering the use of hydroxyurea in their pediatric patients. Results from the BABY HUG Follow-up Study I suggest that continued use of hydroxyurea is both safe and effective in infants with SCA.

The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) was a multicenter, randomized clinical trial that assessed the clinical benefits of hydroxyurea in very young patients with SCA. Results from the study demonstrated that hydroxyurea administered to infants with SCA provided substantial clinical benefit over placebo.

Researchers launched the BABY HUG Follow-Up Study I in 2008 to assess the safety and efficacy of continued treatment with hydroxyurea in infants with SCA. The Follow-Up Study I included 163 children between the ages of 28 and 44 months who had participated in the BABY HUG trial and who had completed at least 18 months of randomized treatment of either hydroxyurea or placebo. Investigators collected clinical and laboratory data every six months from patient medical records, including use and dosage of hydroxyurea, blood counts, clinical imaging, and frequency of sickle cell-related complications.

At Follow-Up Study entry, families enrolling their children did not know their child's randomized study treatment assignment in BABY HUG; 82 percent initially chose clinical prescription of open-label hydroxyurea, demonstrating a high acceptance rate for the drug. Through the 36 months of follow-up, acceptance remained high, with 68 to 75 percent of the participating families reporting that their children continued
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. ICON Medical Imaging Launches New Service to Boost Reliability of Cardiology Studies
2. OpenClinica EDC Solution Deployed for Retina Implant Studies
3. Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies
4. Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools
5. NIST studies how new helium ion microscope measures up
6. Five New Clinical Studies Show Value of Masimo PVI & PI
7. ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting
8. Isolagen to Host Investor Conference Call to Present an Analysis of the Data from Phase III Wrinkle Studies
9. New Clinical Studies Presented at the American Society of Anesthesiology (ASA) Annual Meeting Show Masimo Technologies Provide Advanced Clinical Intelligence
10. Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
11. Trubion Reports Re-treatment Results Following Phase 1/2a and Phase 2b Studies Evaluating TRU-015 for Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... Canada (PRWEB) August 20, 2014 Not ... that E&L studies should be performed late in the ... is known. But current regulatory trends suggest that, like ... on the rise. In recent years, multiple drug sponsors ... packages or address specific questions during phase I/II. It’s ...
(Date:8/20/2014)... GraphDB™ 6.0 from ... to the enterprise replication cluster, faster loading speeds, ... and Elasticsearch. This release happens to coincide with ... – GraphDB™ was formerly known as OWLIM. ... mature enterprise resilient RDF triplestore will also benefit ...
(Date:8/19/2014)... Aug. 19, 2014 A Geisinger researcher on ... for a Centers for Disease Control and Prevention (CDC) ... public health concern. Joseph Boscarino , ... of a team of researchers nominated for the Centers ... Science Award for Data Methods and Study Design. ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 XenoTech ... fast and cost-effective metabolite production from bioactive small ... chemistry platform, the technology enables convenient and timely ... According to XenoTech’s Vice President of Commercial Operations, ... for assessing clinical risk can be measured directly ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 2Beyond Metabolite Identification, Testable Quantities Now Offered by XenoTech 3
... 28 Clarisonic announced today the expansion of its ... with Look Good…Feel Better ®, ... with breast and other cancers manage their treatment and ... program,s free workshops, volunteer beauty professionals teach patients easy ...
... at the University of New South Wales (UNSW) in Sydney, ... to make a quantum computer using silicon: a "single electron ... Quantum computers promise exponential increases in processing speed over ... orientation, of individual electrons to represent data in their calculations. ...
... day recycle part of their own waste heat, using a ... The material is a semiconductor called gallium manganese arsenide. In ... describe the detection of an effect that converts heat into ... a semiconductor. Once developed, the effect could enable integrated ...
Cached Biology Technology:Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 2Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 3Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 4Clarisonic Empowers Cancer Patients to Put Their Best Face Forward 5Single electron reader opens path for quantum computing 2Semiconductor could turn heat into computing power 2Semiconductor could turn heat into computing power 3
(Date:8/20/2014)... CITY Researchers at Huntsman Cancer Institute (HCI) at the ... of the gene that encodes BCR-ABL, the unregulated enzyme ... to the American Cancer Society, nearly 6,000 new cases ... already in use, called tyrosine kinase inhibitors (TKIs), target ... do not cure CML but control it in a ...
(Date:8/20/2014)... Issue Serious allergic reactions to food ... for some children.    What you should know ... allergies and this number may be increasing, especially among children. ... have food allergies.  The symptoms of allergic ... breathing difficulties and loss of consciousness. Symptoms can also develop ...
(Date:8/20/2014)... in this image of the Para and Mato Grosso ... likely intentionally set in order to deforest the land. ... of trees where the land is thereafter converted to ... forestland to farms, ranches, or urban use. The herringbone-patterned ... Amazon Rainforest in the middle of the image are ...
Breaking Biology News(10 mins):Blueprint for next generation of chronic myeloid leukemia treatment 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... farmers worldwide to plant genetically modified (GM) cotton to ... several years by saving on pesticides have now been ... researchers at the American Agricultural Economics Association (AAEA) Annual ... that other pests are now attacking the GM cotton. ...
... after the end-Cretaceous mass extinction was much more chaotic ... shows that at certain times and places, plant and ... as they are today. The extinction took place 65.5 ... the beginning of the Cenozoic Era and the Paleocene ...
... five major food crops grown under carbon-dioxide levels ... bounty than those raised in earlier greenhouse and ... global food supplies could be at risk without ... are based on on-going open-air research at the ...
Cached Biology News:Bt cotton in China fails to reap profit after seven years 2Insect predation sheds light on food web recovery after the dinosaur extinction 2Insect predation sheds light on food web recovery after the dinosaur extinction 3Insect predation sheds light on food web recovery after the dinosaur extinction 4Food-crop yields in future greenhouse-gas conditions lower than expected 2
Hepatocyte Differentiation Environment...
High voltage electrophoresis power supply...
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
... Drummond Scientific has a long and ... microinjection apparatus. Several years ago we ... displacement microdispenser was being modified to ... unit by redesigning the microdispenser to ...
Biology Products: