Navigation Links
Structure of enzyme against chemical warfare agents determined
Date:5/26/2009

This release is available in German.

The enzyme DFPase from the squid Loligo vulgaris, is able to rapidly and efficiently detoxify chemical warfare agents such as Sarin, which was used in the Tokyo subway attacks in 1995. A detailed understanding of the mechanism by which enzymes catalyze chemical reactions is necessary for efforts aiming to improve their properties. A group of researchers at the University of Frankfurt, the Bundeswehr Institute for Pharmacology and Toxicology in Munich, and Los Alamos National Laboratory in New Mexico, USA, have successfully determined the structure of DFPase using neutron diffraction. They report their findings in the 20 January 2009 issue of the journal Proceedings of the National Academy of Sciences (106(3), 713-718).

The team used the neutron source at Los Alamos National Laboratory, one of only three sources worldwide equipped for protein crystallography. In contrast to structure determination using X-rays, neutrons are able to locate the positions of hydrogen atoms, which make up half of all atoms in proteins, and are crucial for chemical reactions. As X-rays interact with the electron cloud around an atomic nucleus, so heavier elements are more easily seen, while neutrons interact with the atomic nuclei, and atoms in proteins such as hydrogen, oxygen, nitrogen, carbon, and sulfur, all scatter neutrons in a similar manner. Yet despite being so widespread, hydrogen atoms in proteins are quite elusive. As X-rays interact with the electron cloud around an atomic nucleus, hydrogen atoms, with only one electron, are normally invisible in structures. In contrast, neutrons interact with the atomic nuclei, such that atoms in proteins, hydrogen, oxygen, nitrogen, carbon, and sulfur, all scatter neutrons in a similar manner. The two techniques therefore
'/>"/>

Contact: Julian Chen
chen@chemie.uni-frankfurt.de
49-697-982-9641
Goethe University Frankfurt
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria
2. Structure of enzyme against chemical warfare agents determined
3. New security and medical sensor devices made possible by metallic nanostructures
4. ChemImage and Next Breath Structure Partnership to Validate Bioequivalence Testing for Nasal Spray Suspensions
5. Structure of enzyme against chemical warfare agents determined
6. Nanostructure boosts efficiency in energy transport
7. Cord Blood America Restructures Debt; Projects to be Cash Flow Positive
8. Sophisticated nano-structures assembled with magnets
9. New imaging technique reveals the atomic structure of nanocrystals
10. Engineers tune a nanoscale grating structure to trap and release a variety of light waves
11. Scientists prove graphenes edge structure affects electronic properties
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... 25, 2014 Whitehouse Laboratories is ... the Morris County (New Jersey) Chamber of Commerce ... leading business organization in the North Jersey area, ... engage some key clients in the pharmaceutical and ... geographic area. Membership enables Whitehouse Laboratories a higher ...
(Date:11/26/2014)... 2014 The Pittcon marketing department is ... and exposition mobile app, Pittcon 2015 ... the App Store for iOS and Android devices and ... before, during and after the event. It acts as ... companies, technical sessions, Conferee Networking sessions and short courses. ...
(Date:11/26/2014)... DE (PRWEB) November 26, 2014 ... Heroes recognition reception on December 5, 2014, in San ... meeting. The MPN Heroes event will honor clinicians, caregivers, ... field of myeloproliferative neoplasms (MPNs). , Special guest ... discuss his family's cancer journey at the reception. ...
(Date:11/26/2014)... /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio il lancio ... di Hi Europe 2014 (dal 2 al 4 dicembre, ... della curcumina con la maggiore biodisponibilità di sempre, con ... approvati dalle norme europee. La curcumina è ... ( Curcuma longa ) che è stata associata con ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... Dec. 6, 2010 Regeneron Pharmaceuticals, Inc. (Nasdaq: ... 2010 Deutsche Bank BioFest on Tuesday, December 14, 2010. ...  The session may be accessed through the Company,s web ...  An archived version of the presentation will be available ...
... YM BioSciences Inc. (NYSE Amex: YMI ; TSX: ... patients enrolled in the Phase I/II trial for its JAK1/JAK2 ... an oral presentation at the 52nd American Society of Hematology ... "Anemia is the most serious symptom associated with myelofibrosis, so ...
... Md., Dec. 6, 2010 Viruses have a bad ... quickly and precisely replicate itself makes it a destructive ... team of researchers at the University of Maryland,s A. ... and Natural Resources, brought together by Professor Reza Ghodssi, ...
Cached Biology Technology:YM BioSciences Reports Positive Interim Data Including Substantial Anemia Response from Phase I/II Trial of JAK1/JaK2 Inhibitor CYT387 2YM BioSciences Reports Positive Interim Data Including Substantial Anemia Response from Phase I/II Trial of JAK1/JaK2 Inhibitor CYT387 3YM BioSciences Reports Positive Interim Data Including Substantial Anemia Response from Phase I/II Trial of JAK1/JaK2 Inhibitor CYT387 4YM BioSciences Reports Positive Interim Data Including Substantial Anemia Response from Phase I/II Trial of JAK1/JaK2 Inhibitor CYT387 5YM BioSciences Reports Positive Interim Data Including Substantial Anemia Response from Phase I/II Trial of JAK1/JaK2 Inhibitor CYT387 6Bad Virus Put to Good Use: Breakthrough Batteries 2Bad Virus Put to Good Use: Breakthrough Batteries 3Bad Virus Put to Good Use: Breakthrough Batteries 4Bad Virus Put to Good Use: Breakthrough Batteries 5Bad Virus Put to Good Use: Breakthrough Batteries 6
(Date:11/21/2014)... 2014  Earlier this year Donald Spector , ... one of the most prolific inventors in the world, ... from Smartphones to third party agencies. Spector envisioned this ... of the earliest known patents in this area. Now ... military, child care, elder care and hospital applications. This ...
(Date:11/21/2014)... 20, 2014 C-Labs LLC, a leading provider ... Things (IoT), today announced the appointment of John ... Previously a strategic advisor to the firm, Mr. Traynor ... Traynor is based out of the C-Labs office in ... Chris Muench , Chief Executive Officer. ...
(Date:11/18/2014)... WASHINGTON , Nov. 18, 2014  The ... Security Industry Association today jointly announce the formation ... and release of its Identity and Biometric ... (Framework). The Framework received official support from BORDERPOL, ... governments to improve and provide expertise regarding border ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... study shows that land-use policies in Peru have been ... that country. Scientists at the Carnegie Institutions Department of ... years of high-resolution satellite data covering most (79%) of ... published in the August 9, 2007, on-line edition of ...
... New Haven, Conn. It is not just whats in your ... difference between species at least in yeast according to ... Weve known for a while that the protein coding genes ... senior author Michael Snyder , the Cullman Professor of ...
... Today, researchers report for the first time that genetic ... only from the motherare directly linked to metabolic markers ... the role of mitochondrial genome variation in the pathogenesis ... Research ( www.genome.org ). According to the ...
Cached Biology News:Rain forest protection works in Peru 2Evolution is driven by gene regulation 2Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes 2
... Drosophila S2 cells are used for heterologous ... System (DES). The S2 cell line was ... (20-24 hours old) Drosophila melanogaster embryos ... at room temperature without CO2 and is easily ...
... syringe pump series combines Harvard Apparatuss best pump ... a wide range of configuration options. A lookup ... of syringes from all the major manufacturers. A ... the pertinent information from across the lab. All ...
... novel expression vectors, we in-troduced a new concept, ... at tran-scriptional level at the T7 phage promoter, ... amplifying the plasmid copy number, The main advantage ... retains practically all of the outstanding features of ...
... This CLS number is a new product ... number. If showing no availability yet, please ... or contact customer service for assistance. ... Comp Dim: surface area 21 cm 2 ...
Biology Products: