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million in the first quarter of 2008 from $787 million in the same
period in 2007. The comparison to the first quarter 2007 sales reflects
the adverse impact of generic competition for PLAVIX(R) in 2007, which
the company estimates to be in the range of $200 million to $250
million. Estimated total U.S. prescription demand for clopidogrel
bisulfate (branded and generic) increased by 4% in the first quarter of
2008 compared to 2007. Estimated total U.S. prescription demand for
branded PLAVIX(R) increased by 78% in the same period.
-- Total revenue for ABILIFY(R), an agent for the treatment of
schizophrenia, bipolar disorders and major depressive disorder,
increased 24% to $454 million in the first quarter of 2008 from $366
million in the same period in 2007. U.S. sales increased 19% to $348
million in the first quarter 2008 from $293 million in the same period
in 2007, primarily due to higher demand. Estimated total U.S.
prescription demand increased approximately 14% compared to the same
period last year. International sales increased 45%, including a 16%
favorable foreign exchange impact, to $106 million in the first quarter
of 2008 from $73 million in the same period in 2007, due to continued
growth across European markets. Total revenue for ABILIFY(R) primarily
consists of alliance revenue representing the company's 65% share of
net sales in countries where it copromotes with Otsuka Pharmaceutical
Co., Ltd.
-- Sales of AVAPRO(R)/AVALIDE(R), an angiotensin II receptor blocker for
the treatment of hypertension, also part of the sanofi-aventis
alliance, increased 13%, including a 6% favorable foreign exchange
impact, to $305 million in the first quarter of 2008 from $270 million
in the same period in 20
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