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Strategic Development of Neural Stem & Progenitor Cell Products
Date:11/21/2013

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While development of therapies that involve embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs) continue to expand, development of neural stem cell therapies has been more substantially affected by barriers to entry, including patent restrictions, the dominance of current competitors, and the complexity of neural stem cell applications. Nonetheless, within the area of NSC therapy development, there are currently three dominant competitors, which are Neural Stem, Neuron ova AB, and Neuron Generation. In addition to those companies, there are also more than a dozen other companies actively developing NSC therapies for use in the treatment of human injury and disease.

For this reason, development of NSC products by the pharmaceutical sector also represents a thriving segment of the global NSC product marketplace. Of particular interest to this community is the potential for use of NSCs to heal tissues that have a naturally limited capacity for renewal, such human brain and spinal cord tissues.

Furthermore, within the pharmaceutical sector, development of new drugs is extremely costly and the success rate of bringing new compounds to the market is unpredictable. Therefore, it is crucial that pharmaceutical companies minimize late-stage product failures, such as suboptimal pharmacokinetic properties or unexpected neurotoxicity effects that can arise when candidate drugs enter the clinical testing stages. To achieve this, it would be highly desirable to test candidate drugs using in vitro assays of high human relevance as early as possible. Because NSCs have the potential to differentiate into nearly all of the main phenotypes of the nervous system, they represent an ideal cell type from which to design such neural screening assays.

In summary, the unifying factor within the NSC product marketplace is that all companies involved need to understand market forces, trends, metri
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SOURCE Bharat Book Bureau
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