Stimulus Grant To Fund 'Whole-Genome Sequencing' In Children W...(hospital.org/newsroom/Site1339/mainpageS...)

Date:9/30/2009

hospital.org/newsroom/Site1339/mainpageS1339P1sublevel445.html">reported that some autism mutations may affect "promoter" or "enhancer" sequences, bits of DNA that act as "on/off" switches controlling gene activity. Now, Greenberg's lab will study living, active neurons to create a systematic map of these critical switches in the human genome, while the Children's hospital team searches for the relationship between these switches and autism.

Because Grand Opportunity funding requires that the grant money be spent within 18 months, the project will move rapidly. The project's ultimate goal is to relate different forms of clinical autism to variations in both DNA and gene activity, and to make this information available to all autism researchers.

The Nancy Lurie Marks Foundation, as well as the Simons Foundation, provided the initial seed money for Walsh's team to research autism in the Middle Eastern families. Walsh is also supported by the Howard Hughes Medical Institute.

Children's Hospital Boston is home to the world's largest research enterprise based at a pediatric medical center, where its discoveries have benefited both children and adults since 1869. More than 500 scientists, including eight members of the National Academy of Sciences, 12 members of the Institute of Medicine and 12 members of the Howard Hughes Medical Institute comprise Children's research community. Founded as a 20-bed hospital for children, Children's Hospital Boston today is a 396-bed comprehensive center for pediatric and adolescent health care grounded in the values of excellence in patient care and sensitivity to the complex needs and diversity of children and families. Children's also is the primary pediatric teaching affiliate of Harvard Medical School. For more information about the hospital and its research visit: www.childrenshospital.org/news
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SOURCE Children's Hospital Boston Copyright©2009 PR Newswire. All rights reserved

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