Navigation Links
Stevens researchers provide new information about mass spectrometry
Date:10/15/2007

HOBOKEN, N.J. Fresh data on mass spectrometry are presented in the report Low-energy collision-induced fragmentation of negative ions derived from ortho-, meta-, and para-hydroxyphenyl carbaldehydes, ketones, and related compounds, produced by Professor Athula Attygalle and his colleagues in the Center for Mass Spectrometry at Stevens Institute of Technology.

According to a study, Collision-induced dissociation (CID) mass spectra of anions derived from several hydroxyphenyl carbaldehydes and ketones were recorded and mechanistically rationalized. For example, the spectrum of m/z 121 ion of deprotonated ortho-hydroxybenzaldehyde shows an intense peak at m/z 93 for a loss of carbon monoxide attributable to an ortho-effect mediated by a charge-directed heterolytic fragmentation mechanism.

In contrast, the m/z 121 ion derived from meta and para isomers undergoes a charge-remote homolytic cleavage to eliminate an *H and form a distonic anion radical, which eventually loses CO to produce a peak at m/z 92. In fact, for the para isomer, this two-step homolytic mechanism is the most dominant fragmentation pathway. The spectrum of the meta isomer on the other hand, shows two predominant peaks at m/z 92 and 93 representing both homolytic and heterolytic fragmentations, respectively. (18)O-isotope-labeling studies confirmed that the oxygen in the CO molecule that is eliminated from the anion of meta-hydroxybenzaldehyde originates from either the aldehydic or the phenolic group. In contrast, anions of ortho-hydroxybenzaldehyde and 2-hydroxy-1-naphthaldehyde, both of which show two consecutive CO eliminations, specifically lose the carbonyl oxygen first, followed by that of the phenolic group. Anions from 2-hydroxyphenyl alkyl ketones lose a ketene by a hydrogen transfer predominantly from the alpha position. Interestingly, a very significant charge-remote 1,4-elimination of a H(2) molecule was observed from the anion derived from 2,4-dihydroxybenzaldehy
'/>"/>

Contact: Patrick A. Berzinski
pberzins@stevens.edu
201-216-5687
Stevens Institute of Technology
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology technology :

1. UW-Stevens Point Professor Receives Patent Approval For New Technology
2. Tapping hidden assets: Wisconsin researchers who can create jobs
3. National Academies induct five UW researchers
4. Wisconsin researchers defend stem cell company
5. NimbleGen partners with leading researchers
6. Medical College researchers win federal grants
7. Researchers say scientific reporting needs more perspective, less hype
8. Congress passes bill to ease researchers collaboration worries
9. Researchers report development of embryonic stem cells without destroying embryo
10. New digs for UW AIDS researchers
11. Medical College researchers receive new grants to enhance discovery of heart-protecting anesthetics

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2009)...4,2009/PRNewswire-FirstCall/--ArenaPharmaceuticals...isscheduledtopresentatthePiperJaffray21stAnnualHea...nTime(8:30a.m.PacificTime)attheNewYorkPalaceHoteli...ecutiveOfficer,isscheduledtoprovideanoverviewofthe...yprograms. ,, Aliveaudiowebcastofthepresentatio...
(Date:11/24/2009)... Chemical Abstracts Service (CAS), the global e...s patent office is now the world,s leading produce...hina trailed Japan,s patent office, the World Inte...ted States Patent and Trademark Office (USPTO) for... WIPO in 2006, and exceeded Japan for the first ti...
(Date:11/23/2009)...omises ultra-fast communication, computation and m.... But trying to use quantum states as carriers of ... two physicists have shown, mathematically, how to...ication, while keeping the information intact. The...cal Review Letters and highlighted with a Viewpoi...
(Date:11/23/2009)...Nov.23/PRNewswire-FirstCall/--NeogenCorporation(Na...D.,waselectedtoNeogen,sBoardofDirectorsatthecompan...rhasmorethan40yearsofexperienceinthefood,agricultu...professorofagriculturaleconomicsatVirginiaTechUniv...dStateschiefagriculturenegotiatorwiththerankofamba...
Breaking Biology Technology:Arena Pharmaceuticals to Present at the Piper Jaffray 21st Annual Health Care Conference 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 2China Leads All Nations in Publication of Chemical Patents According to CAS, the World's Most Authoritative Publisher of Chemical Information 3Richard T. Crowder Joins Neogen's Board of Directors 2
...g leg ulcers each year in the US, PRINCETON, N.J....d: DSCI), provider of advanced wound care products...tailing the clinical usage,of its newly released M...ptospermum Honey presented at the annual American ...ence held the second week in March in Forth,Worth,...
...ows for placement of skin grafts ... March 20 Baxter Healthcare,Corporation announced...,approval of ARTISS (Fibrin Sealant (Human)), the ...ed for use in adhering skin grafts in,adult and pe...Baxter,s,proven fibrin sealant technology platform...
... Emerging Therapies Will Not Match, the Current ...fficacy, According to a New Report from ...ision Resources, one of the,world,s leading resear...hcare issues, finds that the emerging drug Zactima...are in the treatment of non-small-cell lung,cancer...
Other Biology Technology:Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 2Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 3Derma Sciences Announces Clinical Poster on Use of MEDIHONEY(TM) Wound & Burn Dressings Wins First Place Award at APWCA 4Baxter Announces FDA Approval of ARTISS Slow-Setting Fibrin Sealant in Treatment of Burn Patients 2Baxter Announces FDA Approval of ARTISS Slow-Setting Fibrin Sealant in Treatment of Burn Patients 3AstraZeneca's Zactima to Earn Almost Five Percent Patient Share in the Treatment of Non-Small-Cell Lung Cancer by 2016 2
(Date:11/23/2009)...dy by University of Alabama at Birmingham (UAB) re...existing medical conditions (co-morbidity) do not ...can-Americans compared to Caucasians who also have...23 in Cancer , a journal of the American Cancer S...I and co-morbidity are independent predictors of p...
(Date:11/23/2009)...s reveal in unprecedented detail how the ribosome ...teins and guide them toward their destination in b...cs flexible fitting (MDFF) to examine the interact...artners. , The first study, in Proceedings of ...timate signaling between the ribosome and an elong...
(Date:11/23/2009)...cent discoveries about the multiple health benefit...purpose nutrient, increased awareness of the huge ... research and even led to an appreciation of it as... the health of your immune system to prevention of..., vitamin D is now seen as one of the most critica...
Breaking Biology News(10 mins):Racial disparity in colon cancer survival not easily explained, UAB researchers say 2Computational microscope peers into the working ribosome 2Computational microscope peers into the working ribosome 3Multiple health concerns surface as winter, vitamin D deficiences arrive 2Multiple health concerns surface as winter, vitamin D deficiences arrive 3Studies in animals suggest 2009 H1N1 virus may have biological advantage over seasonal influenza 55873 1Studies in animals suggest 2009 H1N1 virus may have biological advantage over seasonal influenza 55873 2Biotransformed blueberry juice fights fat and diabetes 55868 1Biotransformed blueberry juice fights fat and diabetes 55868 2New information about how fat increases blood pressure could help identify those at risk 9752 1New information about how fat increases blood pressure could help identify those at risk 9752 2New information about how fat increases blood pressure could help identify those at risk 9752 3
...od memory even in your twilight years is the first...ey can control their memory are more likely to emp...despite the march of time. These are the conclusio...ls of Gerontology: Psychological Sciences. , The s...functioning and a low sense of control, and examin...
...um is becoming more prevalent in many intensive ca...sue of Clinical Infectious Diseases, now available...reus (MRSA) is responsible for a variety of infect...Skin infections are the most common, but MRSA can ...e tract. The emergence of MRSA and other drug-resi...
...rogress toward elucidating key genetic events asso...tiple myeloma (MM), an incurable malignancy that i...results, published in the April issue of Cancer Ce...at open innovative directions for the discovery of...ecific MM patients based on genetic perturbations ...
Other Biology News:Confidence in memory performance helps older adults remember 2Drug-resistant bacteria patterns in intensive care units changing nationally 2Genome changes tracked during multiple myeloma initiation, progression and treatment 2
Anti-Foam Reagent from Promega
Rat Tissue Array: Brain, heart, kidney, liver, lung, muscle, spleen and stomach, each tissue from 10 female and 10 male, respectively from BioChain
EPH electrode, anode from GE Healthcare, formerly Amersham Biosciences
Sperm viability Fluorometric (green) Assay Kit, LIVE/DEAD® from Molecular Probes (Invitrogen)
Biology Products: