Navigation Links
Stevens researchers provide new information about mass spectrometry
Date:10/15/2007

HOBOKEN, N.J. Fresh data on mass spectrometry are presented in the report Low-energy collision-induced fragmentation of negative ions derived from ortho-, meta-, and para-hydroxyphenyl carbaldehydes, ketones, and related compounds, produced by Professor Athula Attygalle and his colleagues in the Center for Mass Spectrometry at Stevens Institute of Technology.

According to a study, Collision-induced dissociation (CID) mass spectra of anions derived from several hydroxyphenyl carbaldehydes and ketones were recorded and mechanistically rationalized. For example, the spectrum of m/z 121 ion of deprotonated ortho-hydroxybenzaldehyde shows an intense peak at m/z 93 for a loss of carbon monoxide attributable to an ortho-effect mediated by a charge-directed heterolytic fragmentation mechanism.

In contrast, the m/z 121 ion derived from meta and para isomers undergoes a charge-remote homolytic cleavage to eliminate an *H and form a distonic anion radical, which eventually loses CO to produce a peak at m/z 92. In fact, for the para isomer, this two-step homolytic mechanism is the most dominant fragmentation pathway. The spectrum of the meta isomer on the other hand, shows two predominant peaks at m/z 92 and 93 representing both homolytic and heterolytic fragmentations, respectively. (18)O-isotope-labeling studies confirmed that the oxygen in the CO molecule that is eliminated from the anion of meta-hydroxybenzaldehyde originates from either the aldehydic or the phenolic group. In contrast, anions of ortho-hydroxybenzaldehyde and 2-hydroxy-1-naphthaldehyde, both of which show two consecutive CO eliminations, specifically lose the carbonyl oxygen first, followed by that of the phenolic group. Anions from 2-hydroxyphenyl alkyl ketones lose a ketene by a hydrogen transfer predominantly from the alpha position. Interestingly, a very significant charge-remote 1,4-elimination of a H(2) molecule was observed from the anion derived from 2,4-dihydroxybenzaldehyde, wrote Attygalle and his colleagues from Stevens.

The researchers concluded: For this mechanism to operate, a labile hydrogen atom should be available on the hydroxyl group adjacent to the carbaldehyde functionality.


'/>"/>

Contact: Patrick A. Berzinski
pberzins@stevens.edu
201-216-5687
Stevens Institute of Technology
Source:Eurekalert

Related biology technology :

1. UW-Stevens Point Professor Receives Patent Approval For New Technology
2. Tapping hidden assets: Wisconsin researchers who can create jobs
3. National Academies induct five UW researchers
4. Wisconsin researchers defend stem cell company
5. NimbleGen partners with leading researchers
6. Medical College researchers win federal grants
7. Researchers say scientific reporting needs more perspective, less hype
8. Congress passes bill to ease researchers collaboration worries
9. Researchers report development of embryonic stem cells without destroying embryo
10. New digs for UW AIDS researchers
11. Medical College researchers receive new grants to enhance discovery of heart-protecting anesthetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/17/2017)... ... July 17, 2017 , ... Panitch Schwarze Belisario ... in the BiG (Biomedical Innovation Group) annual meeting in China. , This year’s ... antigen receptor T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that involves ...
(Date:7/16/2017)... , ... July 16, 2017 , ... ... and analytical instruments announced the launch of its new line of Rocking and ... rocking and waving shaker models (both analog and digital) for laboratory applications in ...
(Date:7/14/2017)... ... 14, 2017 , ... Sonic Manufacturing Technologies is proud to ... a solar system on its roof top. “We will be independent of the ... Raab stated. The company’s proud history of social responsibility and participation in the ...
(Date:7/14/2017)... ... July 14, 2017 , ... Diagenode and PreOmics ... to clean peptides for mass spectrometry (MS) analysis combining the PreOmics in-StageTip Kit ... Kit is based on proprietary technology that contains optimized buffer systems permitting ultrafast ...
Breaking Biology Technology:
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:3/30/2017)...  On April 6-7, 2017, Sequencing.com will host the ... hackathon at Microsoft,s headquarters in Redmond, Washington ... developing health and wellness apps that provide a unique, ... is the first hackathon for personal genomics and ... in the genomics, tech and health industries are sending ...
Breaking Biology News(10 mins):