Navigation Links
Stem cells' 'suspended' state preserved by key step, scientists report
Date:7/8/2009

Scientists have identified a gene that is essential for embryonic stem cells to maintain their all-purpose, pluripotent state. Exploiting the finding may lead to a greater understanding of how cells acquire their specialized states and provide a strategy to efficiently reprogram mature cells back into the pluripotent state, an elusive step in stem cell research but one crucial to a range of potential clinical treatments.

The research was led by University of California, San Francisco scientists. It is being reported Wednesday, July 8, 2009, in the advanced online edition of the journal Nature, and will be published in the journal's print edition at the end of July.

Embryonic stem cells are suspended in an "open" state, uniquely poised to become any one of many types of specialized cells, as genetic instructions dictate. Directing the specialization of embryonic stem cells to cells needed by patients is an area of enormous promise in stem cell research. Reversing the natural process -- converting specialized cells back into the all-purpose stem cell stage is another great promise of stem cell research.

Reprogramming specialized cells from Parkinson's patients, for example, would allow scientists to study the mechanisms that cause neurons in the brain to develop the disease. It also could lead to treatments by directing the restored stem cells to produce healthy neurons to introduce into patients.

The new research, conducted on mouse embryo cells, revealed that a gene known as Chd1 loosens the packaging that normally protects DNA in the cell nucleus. This step, known as chromatin remodeling, allows the cell's protein-making machinery to gain access to the DNA and transform progenitor cells into specialized cells and tissue, such as neurons, muscle and bone.

A number of genes are known to trigger chromatin remodeling, allowing small sections of DNA to become accessible in order to make specific proteins. Chd1
'/>"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Cellular Dynamics International Reprograms Blood Cells into Stem Cells
2. Scientists identify gene vital to early embryonic cells forming a normal heart and skull
3. OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial
4. Adipose-derived Stem Cells Could Help Traumatic Brain Injury Patients, Says Bio-Matrix Scientific Groups, Entest BioMedical Inc. Researcher
5. Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3
6. Bio-Matrix Scientific Group & Entest BioMedical Submit Research Proposal to U.S. Army for Funding Adipose-Derived Stem Cells to Treat Traumatic Brain Injury
7. Solar cells, geological storage research receive DOE funding at the University of Texas at Austin
8. STEMCELL Technologies Introduces a New Animal Component-Free, Serum-Free Medium for Culturing Human Mesenchymal Stem Cells
9. CEL-SCI Presents Data at Prestigious Medical Conference Demonstrating That Its L.E.A.P.S. Technology Stimulates Maturation of Human Blood Cells Into Dendritic Cells Suggesting Potential for Prevention and Treatment of Infectious Disease
10. Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110
11. Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
(Date:8/28/2014)... A new research platform uses a ... tiny structures undergoing stress and heating, an ... designs for microelectronics and batteries., This new ... about how heating and the surface stress ... Researchers have discussed the merits of surface-stress ...
(Date:8/28/2014)... ATLANTA , Aug. 28, 2014   SunTrust ... of three industry veterans to its equity research ... "Our ongoing expansion in equity research demonstrates ... with unique insights to enhance their investment decision ... Equities at STRH.  "We continue to make significant ...
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
Breaking Biology Technology:Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3
... in Orlando, I spoke at the well-attended BICSI Conference . ... PEAK 10's data centers to get a first-hand view ... after doing some online research, and I figured I would have ... another article because data centers have become an issue. ...
... Wis. - Citing one-time gains due to Hurricane Katrina ... has reported a net loss of nearly $45 million, ... 2006. , ,The information management services firm reported net income ... the fourth quarter of 2005, a drop of 29.6 percent. ...
... Wis. - AT&T Wisconsin will create 200 ... a new Internet-based video service that soon will be available ... Scott T. VanderSanden, president of AT&T Wisconsin, and Seth Rosen, ... (CWA), said the new jobs will be located at an ...
Cached Biology Technology:Data centers: Blowing smoke and raising red flags 2Data centers: Blowing smoke and raising red flags 3Data centers: Blowing smoke and raising red flags 4Data centers: Blowing smoke and raising red flags 5Data centers: Blowing smoke and raising red flags 6
(Date:8/28/2014)... million kilometres of new roads will be built worldwide ... Earth,s last wildernesses, where they bring an influx of ... an ambitious study has created a ,global roadmap, for ... balance the competing demands of development and environmental protection. ... that estimates that natural importance of ecosystems and a ...
(Date:8/28/2014)... Wally Broeker, the first person to alert the world ... to be captured and stored underground. He says ... emissions, is the best way to avoid global warming ... Professor Broeker (Columbia University, New York) made the call ... Reykjavik, Iceland, where 150 scientists are meeting to discuss ...
(Date:8/28/2014)... at Ludwig-Maximilians-Universitaet (LMU) in Munich have assigned a ... of predatory arthropods. These animals lived in shallow ... related forms found in Jurassic strata. , ... shallow marine habitat and were fossilized some 435 ... denizens of the Silurian seas although they ...
Breaking Biology News(10 mins):Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Paleontology: Oldest representative of a weird arthropod group 2
... 2012 According to a ... - By Model / type (two-, three-, ... Healthcare, Government, Defense, Travel & Immigration, Consumer ... (2012 - 2017)", published by MarketsandMarkets ( http://www.marketsandmarkets.com ), ...
... higher yield than their homozygous parents. Plant breeders have ... this effect called heterosis for richer harvests. Until now, ... phenomenon. Researchers at the University of Bonn and partners ... possible mechanism in corn roots. More genes are active ...
... field work by associate professor James Davis Reimer and two ... in Okinawa, Japan has found two new species of encrusting ... species belong to the genus Neozoanthus , which was ... Ocean. Surprisingly, the new species were found in the Pacific ...
Cached Biology News:Multi-Factor Authentication Market Worth $5.45 Billion by 2017 2Multi-Factor Authentication Market Worth $5.45 Billion by 2017 3Multi-Factor Authentication Market Worth $5.45 Billion by 2017 4Corn: Many active genes - high yield 2Corn: Many active genes - high yield 3An ocean away: 2 new encrusting anemones found in unexpected locations 2
Hybridization Buffer 3.6 ml...
Mouse monoclonal [0.N.305] to G protein alpha - BSA and Azide free ( Abpromise for all tested applications). Antigen: Partially purified G protein alpha from rat brain. Entrez GeneID: 2778 ...
Rabbit polyclonal to hCG ( Abpromise for all tested applications). entrezGeneID: 1081 SwissProtID: P01215...
Glutathione Agarose Beads 10 ml...
Biology Products: