Navigation Links
Stem cells stand up for themselves

Adult stem cells are not pampered pushovers. O'Reilly et al. report that certain stem cells take charge of their surroundings, molding their environment to control their division and differentiation.

Some stem cells are cosseted like newborns. Neighboring cells cradle them in a structure called the niche. The niche not only nurtures its charges, it also dictates their behavior, determining whether they reproduce and specialize. The standard view is that the niche shapes stem cells, not vice versa.

O'Reilly et al. found evidence for more active stem cells while studying how the cells anchor themselves in the Drosophila ovary.

Previous work indicated that ovary stem cells attach to the niche through the protein E-cadherin. O'Reilly et al. tested whether the stem cells also depend on integrins, cell surface proteins that link molecules in the extracellular matrix to the cytoskeleton.

They found that follicle stem cells (FSC)one type of ovary stem celldrifted away from their niche when they carried mutant integrins.

These breakaway cells were abnormally shaped, divided more slowly than normal, and displayed some cancer-like characteristics, such as refusing to stop crawling even after contacting another cell.

Integrins hook onto an extracellular matrix protein called laminin A. FSCs pump out laminin A, and the scientists found that mutant cells that were unable to make the protein broke their moorings and reproduced sluggishly. Two other kinds of stem cells in the ovarygermline stem cells, which spawn the egg, and escort stem cells, which travel along with itdidn't rely on integrins for anchoring, the researchers showed. The team concluded that the interaction between laminin A and integrins ensures that FSCs remain in place, primed to divide. By laying down laminin A, therefore, FSCs help build their own niche.


Contact: Sati Motieram
Rockefeller University Press

Page: 1

Related biology technology :

1. UC Riverside researcher develops novel method to grow human embryonic stem cells
2. ArunA Biomedical Announces Exclusive Worldwide Technology Licensing Agreement to Commercialize Human Embryonic Stem Cell Derived Mesenchymal Cells
3. Limbs saved by menstrual blood stem cells
4. Suzanne Somers To Promote Growing Importance of Storing Your Own Adult Stem Cells Under Alliance With NeoStem, Inc.
5. Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells
6. New technique produces genetically identical stem cells
7. Access Pharmaceuticals Presents New Data at International Symposium Showing Companys Angiolix(R) Monoclonal Antibody has Potential to Treat Cancer by Attacking Cancer Stem Cells
8. How buckyballs hurt cells
9. Many paths, few destinations: How stem cells decide what theyll be
10. New efficiency record for solar cells
11. Neuralstem Responds to New StemCells, Inc. Lawsuit
Post Your Comments:
(Date:11/24/2015)... SAN DIEGO , Nov. 24, 2015 Halozyme Therapeutics, ... Jaffray Healthcare Conference in New York on ... Dr. Helen Torley , president and CEO, will provide a ... New York at 1:00 p.m. ET/10:00 a.m. ... communication and investor relations, will provide a corporate overview. --> ...
(Date:11/24/2015)... Mass. (PRWEB) , ... November 24, 2015 , ... ... to maintain healthy metabolism. But unless it is bound to proteins, copper is ... of Health (NIH), researchers at Worcester Polytechnic Institute (WPI) will conduct a systematic ...
(Date:11/24/2015)... - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) (the "Company"), ... Toronto Stock Exchange, confirms that as of the date ... that would cause the recent movements in the Company,s ... About Aeterna Zentaris Inc. . ... Zentaris is a specialty biopharmaceutical company engaged in developing ...
(Date:11/24/2015)... 24, 2015 --> ... report "Oligonucleotide Synthesis Market by Product & Services (Primer, ... Diagnostic, DNA, RNAi), End-User (Research, Pharmaceutical & Biotech, Diagnostic ... the market is expected to reach USD 1,918.6 Million ... a CAGR of 10.1% during the forecast period. ...
Breaking Biology Technology:
(Date:11/2/2015)...  SRI International has been awarded a contract of ... to the National Cancer Institute (NCI) PREVENT Cancer Program ... modern testing and support facilities, and analytical instrumentation to ... studies to evaluate potential cancer prevention drugs. ... Drug Development Program is an NCI-supported pipeline to bring ...
(Date:10/29/2015)... BOSTON , Oct. 29, 2015  Connected health ... phenomena driving the explosion of technology-enabled health and wellness, ... his new book, The Internet of Healthy ... apps, sensors or smartphones even existed, Dr. Kvedar, vice ... model of health care delivery, moving care from the ...
(Date:10/27/2015)... , Oct. 27, 2015 Synaptics Inc. (NASDAQ: ... today announced that Google has adopted the Synaptics ® ... controller solutions to power its newest flagship smartphones, the ... Huawei. --> --> ... Google to provide strategic collaboration in the joint development ...
Breaking Biology News(10 mins):