Navigation Links
Stem cells stand up for themselves
Date:8/25/2008

Adult stem cells are not pampered pushovers. O'Reilly et al. report that certain stem cells take charge of their surroundings, molding their environment to control their division and differentiation.

Some stem cells are cosseted like newborns. Neighboring cells cradle them in a structure called the niche. The niche not only nurtures its charges, it also dictates their behavior, determining whether they reproduce and specialize. The standard view is that the niche shapes stem cells, not vice versa.

O'Reilly et al. found evidence for more active stem cells while studying how the cells anchor themselves in the Drosophila ovary.

Previous work indicated that ovary stem cells attach to the niche through the protein E-cadherin. O'Reilly et al. tested whether the stem cells also depend on integrins, cell surface proteins that link molecules in the extracellular matrix to the cytoskeleton.

They found that follicle stem cells (FSC)one type of ovary stem celldrifted away from their niche when they carried mutant integrins.

These breakaway cells were abnormally shaped, divided more slowly than normal, and displayed some cancer-like characteristics, such as refusing to stop crawling even after contacting another cell.

Integrins hook onto an extracellular matrix protein called laminin A. FSCs pump out laminin A, and the scientists found that mutant cells that were unable to make the protein broke their moorings and reproduced sluggishly. Two other kinds of stem cells in the ovarygermline stem cells, which spawn the egg, and escort stem cells, which travel along with itdidn't rely on integrins for anchoring, the researchers showed. The team concluded that the interaction between laminin A and integrins ensures that FSCs remain in place, primed to divide. By laying down laminin A, therefore, FSCs help build their own niche.


'/>"/>

Contact: Sati Motieram
motierd@mail.rockefeller.edu
212-327-8581
Rockefeller University Press
Source:Eurekalert

Page: 1

Related biology technology :

1. UC Riverside researcher develops novel method to grow human embryonic stem cells
2. ArunA Biomedical Announces Exclusive Worldwide Technology Licensing Agreement to Commercialize Human Embryonic Stem Cell Derived Mesenchymal Cells
3. Limbs saved by menstrual blood stem cells
4. Suzanne Somers To Promote Growing Importance of Storing Your Own Adult Stem Cells Under Alliance With NeoStem, Inc.
5. Global Stem Cell Forum in China Showcases Cutting Edge Research, Focuses on New Findings for iPS Cells
6. New technique produces genetically identical stem cells
7. Access Pharmaceuticals Presents New Data at International Symposium Showing Companys Angiolix(R) Monoclonal Antibody has Potential to Treat Cancer by Attacking Cancer Stem Cells
8. How buckyballs hurt cells
9. Many paths, few destinations: How stem cells decide what theyll be
10. New efficiency record for solar cells
11. Neuralstem Responds to New StemCells, Inc. Lawsuit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... , Jan. 20, 2017 Ginkgo ... of Gen9, a pioneer in the synthesis and ... unique expertise in assembling pathway-length synthetic DNA into ... and capacity in the construction of new organism ... industries. "Gen9 was founded to significantly ...
(Date:1/19/2017)... and HOUSTON , ... ("NX Prenatal") today announced the formation of its ... leading clinicians and industry veterans who enhance the ... as it accelerates development of its novel prenatal ... provide medical, clinical and strategic guidance for the ...
(Date:1/19/2017)... Md. and GAITHERSBURG, Md. ... (NYSE MKT: PIP) and Altimmune, Inc., a privately-held ... signing of a definitive agreement for the merger ... Altimmune,s current investors include Novartis Venture Fund, HealthCap, ... will be a fully-integrated and diversified immunotherapeutics company ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... FireflySci Inc. ... exponential rate. The tremendous growth is accounted to two main factors. The ... and the expanding network of vendors supplying FireflySci products all around the world. , ...
Breaking Biology Technology:
(Date:12/15/2016)... Dec. 15, 2016 Advancements in ... health wellness and wellbeing (HWW), and security ... three new passenger vehicles begin to feature ... recognition, heart beat monitoring, brain wave monitoring, ... monitoring, and pulse detection. These will be ...
(Date:12/15/2016)... -- "Increase in mobile transactions is driving the growth ... is expected to grow from USD 4.03 billion in ... CAGR of 29.3% between 2016 and 2022. The market ... for smart devices, government initiatives, and increasing penetration of ... expected to grow at a high rate during the ...
(Date:12/8/2016)... Market Research Future published a half cooked research report on Mobile ... Service Market is expected to grow over the CAGR of ~35% ... ... Mobile Biometric Security and Service Market is increasing at ... and security from unwanted cyber threats. The increasing use of mobile ...
Breaking Biology News(10 mins):