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Stem cells produce compact, regenerated bone in mandible transplants
Date:3/15/2013

as well as researchers from Università Politecnica delle Marche, Ancona, Italy; Université CB, Lyon; European Synchrotron Radiation Facility, Grenoble, France; and the University of Michigan in the United States.

“This must be taken into consideration when grafting stem cells,” Dr. Papaccio continued. “Their behavior may be quite variable and, consequently, their differentiation fate in some cases may be affected more by their specific origin than by the local signals of the treated area.

“Although the bone regenerated at the graft sites is not of the proper type found in the mandible,” he added, “it does seem to have a positive clinical impact. In fact, it creates steadier mandibles, may well increase implant stability and, additionally, may improve resistance to mechanical, physical, chemical and pharmacological agents.”

“Dental pulp is an interesting source of ready-to-use stem cells to treat bone defects,” said Anthony Atala, M.D., Editor of STEM CELLS Translational Medicine and Director of the Wake Forest Institute for Regenerative Medicine. “The finding that these cells regenerate compact bone in the mandible indicates a potential role in the treatment of oral cancer.”

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The full article, “Three years after transplants in human mandibles, histological and in-line HT revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.<
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