Navigation Links
Stem cell transplant restores memory, learning in mice
Date:4/21/2013

MADISON For the first time, human embryonic stem cells have been transformed into nerve cells that helped mice regain the ability to learn and remember.

A study at the University of Wisconsin-Madison is the first to show that human stem cells can successfully implant themselves in the brain and then heal neurological deficits, says senior author Su-Chun Zhang, a professor of neuroscience and neurology.

Once inside the mouse brain, the implanted stem cells formed two common, vital types of neurons, which communicate with the chemicals GABA or acetylcholine. "These two neuron types are involved in many kinds of human behavior, emotions, learning, memory, addiction and many other psychiatric issues," says Zhang.

The human embryonic stem cells were cultured in the lab, using chemicals that are known to promote development into nerve cells a field that Zhang has helped pioneer for 15 years. The mice were a special strain that do not reject transplants from other species.

After the transplant, the mice scored significantly better on common tests of learning and memory in mice. For example, they were more adept in the water maze test, which challenged them to remember the location of a hidden platform in a pool.

The study began with deliberate damage to a part of the brain that is involved in learning and memory.

Three measures were critical to success, says Zhang: location, timing and purity. "Developing brain cells get their signals from the tissue that they reside in, and the location in the brain we chose directed these cells to form both GABA and cholinergic neurons."

The initial destruction was in an area called the medial septum, which connects to the hippocampus by GABA and cholinergic neurons. "This circuitry is fundamental to our ability to learn and remember," says Zhang.

The transplanted cells, however, were placed in the hippocampus a vital memory center at the other end
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Integrated 3-D Imaging Facilitates Human Face Transplantation
2. Stem Cells: Worldwide Markets for Transplantation, Cord Blood Banking and Drug Development
3. Chimerix Antiviral Compound, CMX001, Meets CMV Phase 2 Primary Endpoint in Allogeneic Hematopoietic Stem Cell Transplant Recipients
4. Machine Preservation Significantly Improves Kidney Transplant Survival Over 3 Years Compared to Traditional box of ice
5. Gut Microbiota Transplantation may Prevent Development of Diabetes and Fatty Liver Disease
6. New Data Shows GeNO LLC Nitric Oxide Delivery System Provided Nitric Oxide With Low Levels of Nitrogen Dioxide for Heart Transplant Patient Evaluation
7. Magnet helps target transplanted iron-loaded cells to key areas of heart
8. Retina transplantation improved by manipulating recipient retinal microenvironment
9. The PROOF Centre of Excellence Partners with OriGene Technologies on Heart & Kidney Transplant Biomarker Program
10. Neuralstem Receives Notice Of Issuance For Patent Covering Human Neural Cell Transplantation For Neurodegenerative Conditions
11. University of Kentucky Medical Center Transplants States 1st SynCardia Total Artificial Heart Patient
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 2014 Rancho BioSciences , the ... manually curated public data source TCGA for ... the data is now available for other oncology groups. ... and internal data sources for their Pharma, Government and ... the data that becomes more easily accessible. Rancho ...
(Date:10/30/2014)... Whitehouse Laboratories has formally announced a ... and Package Test Capacity. Responding to growing demands from ... increase in environmental chamber storage space that will enable ... samples to be securely held on site at Whitehouse ... has already taken place with the recent completion of ...
(Date:10/30/2014)... CARLSBAD, Calif. , Oct. 30, 2014 Isis ... antisense therapeutics, today announced that management will present a company ... 2014 at 8:30 a.m. ET in Boston, MA. ... will be available on the "Investors & Media" section of ... available on the Isis website within 48 hours and will ...
(Date:10/30/2014)... one of the key challenges in the development of ... physicists. , In a paper published today (28 October) ... colleagues show how to make a new type of ... devices, such as high-precision sensors and specialised superfast computers, ... But the methods for trapping these tiny particles are ...
Breaking Biology Technology:Rancho BioSciences Manually Curated TCGA Data Sets Available 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2
... 21, 2011 GeneLink, Inc. (OTCBB: GNLK.OB, ... company, reported financial results for the quarter ended September ... Chairman and CEO stated, "From a business development potential, ... in the history of the Company.  The Company continues ...
... The report " Leukemia Therapeutics ... Assessment & Global Market Forecast (2010 - 2020) ... restraints, and opportunities in North America, & Europe. ... TOC on Leukemia Therapeutics Market (Acute/Chronic Lymphocytic Leukemia & ...
... November 18, 2011 Percentage of revenues ... to medical relief organization building a hospital in Ethiopia ... scientific, technical and medical information products and services, announced ... Aid (ICA) through its "Pillars of Hope" ...
Cached Biology Technology:GeneLink Marketing Efforts Poised to Show Results 2GeneLink Marketing Efforts Poised to Show Results 3MarketsandMarkets: Leukemia Therapeutics Market Worth $11.3 Billion by 2020 2MarketsandMarkets: Leukemia Therapeutics Market Worth $11.3 Billion by 2020 3Elsevier Supports International Crisis Aid Through 'Pillars of Hope' Campaign 2Elsevier Supports International Crisis Aid Through 'Pillars of Hope' Campaign 3
(Date:10/30/2014)... This news release is available in German . ... we as individuals prompt our fellow humans to behave ... to social dilemmas in game theory. Previous studies assumed ... large groups. Nonetheless, scientists from the Max Planck Institute ... us can exert an influence on the cooperative behaviour ...
(Date:10/30/2014)... Biological membranes are mainly composed of lipid bilayers. ... ions onto lipid membranes helps clarify functional processes ... a quantitative description of the equilibria between lipid ... Zbigniew Figaszewski from the University of Bialystok, Poland, ... findings, just published in EPJ E . ...
(Date:10/29/2014)... to date, researchers have used DNA sequencing to uncover ... Joseph Buxbaum, Ph.D., Icahn School of Medicine at Mount ... of Harvard and MIT, and their colleagues examined more ... unrelated people. They identified changes in 107 genes that ... spectrum disorder (ASD) – a jump from the nine ...
Breaking Biology News(10 mins):Together we are strong -- or insufferable 2Together we are strong -- or insufferable 3Together we are strong -- or insufferable 4Ion adsorption matter in biology 2
... patients whose lungs are implanted with a pencil ... of lung function and report better quality of ... Frank C. Sciurba, M.D., reported today at CHEST ... of Chest Physicians. Scientific sessions continue through Thursday, ...
... home residents contract pneumonia, it is a blow to their ... Jean Mayer USDA Human Nutrition Research Center on Aging at ... concentration in the blood may help reduce the risk of ... data, it appears that daily zinc intake can help nursing ...
... activity in overweight children improves their thinking and reduces ... 200 overweight, inactive children ages 7-11 also showed that ... bone density. Is exercise a magic wand ... are still overweight but less so, with less fat, ...
Cached Biology News:Endobronchial valve significantly improves emphysema 2Zinc may reduce pneumonia risk in nursing home elderly 2Exercise improves thinking, reduces diabetes risk in overweight children 2Exercise improves thinking, reduces diabetes risk in overweight children 3
... Fingerprinting II identification and ... optional module that adds ... searches and identification of ... of entries of the ...
Fingerprinting II comparative quantification and polymorphism analysis is an optional module that adds comparative quantification and polymorphism analysis functions to the Fingerprinting II Basic so...
... Ideal for hand-held applications or for use ... with a hand-held eight-port disposable manifold provides ... a multi-channel pipette. The StatMatic II can ... sizes and can completely fill a microplate ...
... The DNA Engine Tetrad thermal ... beyond the pioneering PTC-200 DNA Engine ... times the capacity with a footprint ... high throughput for laboratories that run ...
Biology Products: