Navigation Links
Stem cell discovery could lead to improved bone marrow transplants
Date:1/6/2011

SANTA CRUZ, CA--Researchers at the University of California, Santa Cruz, have identified a key molecule for establishing blood stem cells in their niche within the bone marrow. The findings, reported in the January issue of Cell Stem Cell, may lead to improvements in the safety and efficiency of bone marrow transplants.

Bone marrow transplants are a type of stem cell therapy used to treat cancers such as lymphoma and leukemia and other blood-related diseases. In a bone marrow transplant, the "active ingredients" are hematopoietic stem cells, which live in the bone marrow and give rise to all the different kinds of mature blood cells. The new study shows that hematopoietic stem cells use a molecule called Robo4 to anchor themselves in the bone marrow.

"Robo4 is a rare molecule that is found only in hematopoietic stem cells and in the endothelial cells of blood vessels," said Camilla Forsberg, an assistant professor of biomolecular engineering in the Baskin School of Engineering at UC Santa Cruz. After earlier work in her lab showed that Robo4 is specific for hematopoietic stem cells, Forsberg set out to discover how it functions.

The discovery that the cells need Robo4 to stay in the bone marrow has potential therapeutic implications. An increasingly common alternative to traditional bone marrow transplants (which require anesthesia for the bone marrow extraction) involves harvesting hematopoietic stem cells from the blood. Repeated injections of drugs are needed to get the stem cells to leave the bone marrow and enter the bloodstream so that they can be collected with a blood draw. A drug that blocks Robo4 could be a safer and more effective way to do this, Forsberg said.

"If we can get specific and efficient inhibition of Robo4, we might be able to mobilize the hematopoietic stem cells to the blood more efficiently," she said. "We're already working on that in the second phase of the project."

Robo4 acts a
'/>"/>

Contact: Tim Stephens
stephens@ucsc.edu
831-459-2495
University of California - Santa Cruz
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Thomson Reuters and ChemAxon Partner to Help Speed Drug Discovery for Life Science Researchers
2. Gene Discovery Could Increase Value of Non-Food Crops for Industries Outside of Agriculture
3. Discovery of new molecule can lead to more efficient rocket fuel
4. ASCB Launches The Cell: An Image Library(TM) to Inspire Discovery and Improve Human Health
5. Integrated Medical Systems Technology Recognized as Qualified Therapeutic Discovery
6. StemCyte Awarded $488,950 for Advanced Therapeutic Applications of Umbilical Cord Blood Stem Cells from the Qualifying Therapeutic Discovery Project (QTDP)
7. Tomophase Receives Qualifying Therapeutic Discovery Project (QTDP) Award
8. NOVAVAX Awarded Nearly $1 Million in Grants from IRS Under Qualifying Therapeutic Discovery Project
9. PharmAthene Receives Four Therapeutic Discovery Project Grants Totaling Approximately $850,000
10. Lentigen Awarded $1.2 Million by U.S. Government Under the Qualifying Therapeutic Discovery Project
11. Bolder BioTechnology Announces $1.2 Million in Qualifying Therapeutic Discovery Project Grants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Yuma Regional Cancer Center Officially ... brings comprehensive cancer care to Yuma, Arizona. , ... Center has officially opened. A Mayo Clinic Care ... such as open, semi-private and private infusion rooms, ... Resource Center, hematology, rehabilitation center, a pain management ...
(Date:7/30/2014)... DIEGO , July 30, 2014   Epic ... designs and develops novel diagnostics to personalize and advance ... appoint of Gregory T. Lucier as chairman ... chairman and CEO of Life Technologies (formerly Invitrogen). Mr. ... as Epic commercializes its circulating rare cell analysis platform ...
(Date:7/30/2014)... 2014 Connecticut Center for Advanced Technology, ... East Hartford, Conn., was awarded a Rural Business Enterprise ... project that will determine the feasibility of implementing an ... USDA Rural Development provided $53,000 for CCAT under the ... phase of the feasibility study in fiscal year 2014. ...
(Date:7/30/2014)... LayerBio, Inc., an MIT spinoff developing novel drug ... seed financing from friends and family investors. Proceeds from ... novel sustained-release product for ophthalmology. , "We are grateful ... to this important work," said Dr. Ken Mandell, Founder ... areas in which innovations in drug delivery have already ...
Breaking Biology Technology:Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3
... Ability to Elicit Long-Lasting Tumor Protection In Vivo; Lead ... ... Cancer and/or HIV -, SAN DIEGO, CA, Sept. 24 ... vivo results of its lead therapeutic vaccine candidate for the ...
... availability of ... bone fracture screening, TORONTO, ... in health and wellness solutions, announced,they are developing components for ... assessment. In conjunction with top researchers at Toronto,s University ...
... BIRMINGHAM, Ala., Sept. 24 BioCryst,Pharmaceuticals, Inc. (Nasdaq: ... at the,UBS 2007 Global Life Sciences Conference in ... for Tuesday, September 25, 2007 at 2:00 p.m. ... http://www.biocryst.com . The,presentation will be archived for ...
Cached Biology Technology:Nventa announces publication of HspE7 data 2Nventa announces publication of HspE7 data 3Nventa announces publication of HspE7 data 4Nventa announces publication of HspE7 data 5Cooler Solutions and Leading Research Hospital to Design Revolutionary Osteoporosis Diagnosis Device 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 2BioCryst to Present at UBS 2007 Global Life Sciences Conference 3
(Date:7/30/2014)... change on the world,s animal and plant species ... a new paper by a research team from ... other organizations. The authors claim that most of ... it comes to climate change. , While ... the "direct" threats of changing temperatures and precipitation ...
(Date:7/30/2014)... Oxford University Press (OUP) is pleased to announce its ... Beginning in 2015, OUP and CINP will partner to ... ) as a fully open-access journal. , Alan Frazer, ... that the size and expertise of OUP will further ... become one of the very leading journals within neuropsychopharmacology. ...
(Date:7/30/2014)... , July 30, 2014 ... Global Government Biometric Systems Market 2014-2024   Business Strategies, ... Global Biometric Systems Market 2014-2024" offers the reader ... over the next ten years, alongside potential market ... size forecasts. To view the table ...
Breaking Biology News(10 mins):Conservation scientists asking wrong questions on climate change impacts on wildlife 2OUP to partner with the International College of Neuropsychopharmacology 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 2Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 3Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 4Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 5Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 6Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 7Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 8Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 9Global Government Biometric Systems Market Size, Share, Trends and Forecasts 2014-2024 Available Online by Researchmoz.us 10
... diet high in red meat, fatty products, refined grains, ... be increasing their chance of disease relapse and early ... study, published in the Aug. 15 issue of the ... with stage III colon cancer that has been treated ...
... show it is overwhelmingly likely that life began ... scientists. Professor Chandra Wickramasinghe and colleagues at ... case for panspermia - the theory that life ... across the galaxy. A recent BBC Horizon documentary ...
... torrents of microscopic waves propel white blood cells toward ... holds the potential for better understanding and treatment of ... very high-resolution light microscope, the dynamic waves are made ... protein and a second key player were already known ...
Cached Biology News:'Western' diet linked to increased risk of colon cancer recurrence 2Bursts of waves drive immune system 'soldiers' toward invaders 2Bursts of waves drive immune system 'soldiers' toward invaders 3Bursts of waves drive immune system 'soldiers' toward invaders 4
... Note: Prepared by a modification of ... al., Biotechnol. Bioeng., 11 ... unit will yield an A 260 ... of water (1 cm light path). ...
... Dithiothreitol DTT White solid.. ... disulfides to thiols, so reaction is "driven" to ... not contain waxy surfactant found in many other ... pentobarbitol. Purity: ≥97% by titration. ...
... ``special`` dye stains are $6.00 and ... non-routine) stains are $9.00. This ... block, staining, coverslipping and labeling of ... plaques) ,Bodian`s Stain ,Copper Stain ,Fontana-Masson ...
... Genome ChIP-on-chip Microarray is specifically designed ... pombe) DNA binding proteins by pairing ... microarrays. This set delivers robust hybridization ... true binding events and fewer false ...
Biology Products: