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Stem Cell Transplantation Research at The Cancer Center at Hackensack University Medical Center Aims to Develop 'Designer' Transplants
Date:7/23/2008

HACKENSACK, N.J., July 16 /PRNewswire/ --- Over the past two decades, stem cell transplantation has evolved from being an experimental treatment to one that is a viable option for patients with hematologic (blood) malignancies and other life-threatening blood disorders. Researchers and clinicians at the Adult Blood and Marrow Stem Cell Transplantation Program at The Cancer Center at Hackensack University Medical Center are responsible for many of the innovations and techniques used in today's successful transplants.

Stem cell transplantation researchers in The Cancer Center's Division of Research recently published results of a study in Blood, the scientific journal of the American Society of Hematology, that may take physicians one step closer to performing customized "designer" stem cell transplants that could lead to better treatment outcomes for patients.

The paper, "Overlap Between in vitro Donor Anti-Host and in vivo Post Transplantation T Cell Response Vß Utilization: A New Paradigm for Designer Allogeneic Blood and Marrow Transplantation," was co-authored by Cancer Center researchers Thea Friedman, Ph.D., director of laboratory research; Robert Korngold, Ph.D., chief of the Division of Research; Michele L. Donato, M.D., director of the Blood and Marrow Collection Facility; and Scott D. Rowley, M.D., chief of the Division of Blood and Marrow Stem Cell Transplantation; and researchers from the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia. The paper confirms that a technique - called Vß (beta) spectratype analysis - can be used to identify mature donor T cells (disease-fighting white blood cells) that can be harmful to the patient.

One of the major risks of an allogeneic transplant (one that uses stem cells removed from a donor) is graft-versus-host disease (GVHD). GVHD is a potentially fatal complication that can occur when mature donor T cells that are transferred along with stem cells from donated blood or b
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SOURCE The Cancer Center
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