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Stem Cell Innovations' PluriCells(TM) to Form the Basis of a Liver Assist Device to Support Patients Waiting for Transplant.
Date:2/5/2009

HOUSTON, Feb. 5 /PRNewswire-FirstCall/ -- In a paper published in the most recent issue of Current Gastroenterology Reports, Drs. Norman L. Sussman, Brendan M. McGuire and James H. Kelly describe the need and requirements for a successful liver assist device. "There are currently three times as many patients on the waiting list for liver transplantation as there are organs available and few ways to stabilize them if they enter an acute phase of their disease," said Kelly, CEO of Stem Cell Innovations, Inc. (OTC Pink Sheets: SCLL).

This second generation device, based on the PluriCells, "combines the safety of primary hepatocytes (normal liver cells) with the standardization of a cell line," continued Kelly. "We're building on what we learned from our earlier device which utilizes the C3A cells that form the basis of Stem Cell Innovations' ACTIVTox(R) drug discovery products. We are one of the few companies that can approach this problem from both sides: from the stem cell and from the adult liver cell. We are using our PluriCell(TM) system to understand the requirements of the liver stem cell and our ACTIVTox system to understand the requirements of the mature cell."

Liver disease is a serious problem in the United States and worldwide. There are about 6,500 liver transplantations performed each year in the US, with about 16,000 on the waiting list, about 1,800 of whom will die each year without receiving an organ. A liver assist device would be expected to first find use in such acute cases but could be used more widely as experience grows.

Dr. Norman L. Sussman, MD is currently Director of Hepatology at the University of Utah School of Medicine and is also a Director of Stem Cell Innovations. Dr. Brendan M. McGuire, MD is an Associate Professor of Medicine at the University of Alabama School of Medicine and is not affiliated with SCLL.

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