Navigation Links
Start of Phase IIa Study in Acute Lung Injury Patients Marks Development Milestone
Date:12/19/2011

VIENNA, December 19, 2011 /PRNewswire/ --

APEIRON Biologics AG (Apeiron) announced today that GlaxoSmithKline (GSK), exclusive, worldwide licensee for Apeiron's new investigational recombinant human Angiotensin Converting Enzyme 2 (rhACE2, name: GSK2586881, formerly APN01), has initiated a phase IIa study in patients suffering from Acute Lung Injury.

Apeiron today announced the initiation of a phase IIa clinical study of rhACE2, in patients with Acute Lung Injury (ALI). The study, of which Apeiron's licensee GSK is sponsor, will include subjects with a positive diagnosis of ALI, and will be conducted in the intensive care units of multiple hospitals throughout the United States and Canada.

ALI is an acute, severe injury to the lungs associated with a variety of underlying conditions, such as sepsis, aspiration of acidic gastric contents, trauma, postoperative complications, acute pancreatitis, and pneumonia. According to recent studies, it annually affects hundreds of thousands of individuals worldwide. There are currently no pharmaceutical therapies available to treat this life-threatening condition. The most severe form of ALI, the Acute Respiratory Distress Syndrome (ARDS) has a mortality rate of over 20-40%. The efficacy of GSK2586881 has been tested in several preclinical animal models of ALI/ARDS. A phase I study in healthy volunteers also investigated the safety, tolerability and pharmacology profile of this investigational medicine.  In January 2010, GSK acquired an exclusive, worldwide license to further develop and commercialize GSK2586881 in a deal worth up to EUR 230 Mio, subject to reaching future development milestones in multiple indications.

Hans Loibner, CEO of Apeiron stated: "We are excited to see our innovative biologic APN01, after only 6 years in development, now being tested by our licensee GSK in a multicentric phase II study in ALI patients. The study is designed to provide import
'/>"/>

SOURCE APEIRON Biologics AG
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Mexican State of Tamaulipas Starts Training Doctors in Sangui Wound Management
2. Global Cleantech Cluster Association Names New York City Startup Rentricity to Global Top 10 List
3. Garage Start-ups Now Possible in Life Sciences Industry
4. Angioslide Named One of Israels Top Ten Most Promising Startups of 2011
5. False starts can sneak by in womens sprinting
6. Good Start Genetics™ Announces Validation Results for its Next-Generation DNA Sequencing Platform for Genetic Disorder Carrier Screening
7. ViiV Healthcare Starts Phase III Clinical Programme of Celsentri/Selzentry® (maraviroc) versus Truvada® (tenofovir + FTC), in combination with a Protease Inhibitor in people living with HIV
8. Midwest Health Care Startups Raise $315 Million in First Half of 2011
9. Start of in-Patient Clinical Trials With NT-KO-003, the First Neuroprotective Drug for Multiple Sclerosis Without Immunosuppressive Effects
10. Convergence Pharmaceuticals Announces Start of Phase II Study for its Selective Nav 1.7 blocker CNV1014802
11. BioNeutral Starts Commercial Deployment of Its Ygiene 206 Sterilant and Ogiene Products Within Port Authority Facilities Using T.U.C.S. Cleaning Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... CITY, Calif. , March 4, 2015 /PRNewswire/ ... ), a specialty pharmaceutical company focused on the ... treatment of acute and breakthrough pain, today announced ... 2014 financial results after market close on Monday, ... investment-community conference call at 4:30 p.m. Eastern Time ...
(Date:3/4/2015)... San Jose, California (PRWEB) March 04, 2015 ... Chain Reaction (PCR) represents one of the fastest growing ... among cell biologists in subcellular visualization is driving growth ... The need for deeper understanding of gene expressions will ... reagents market. Expanding applications in fields ranging from pharma, ...
(Date:3/4/2015)... ANDOVER, Massachusetts , March 4, 2015 /PRNewswire/ ... Unternehmen präsentiert innovative Entwicklungen für Diagnostik und Therapie, ... Gesundheitsversorgung   Royal Philips ... am Europäischen Röntgenkongress 2015 (ECR) bekannt, ... stattfindet. An den Ständen Nr. ...
(Date:3/3/2015)... 3, 2015 NASA astronaut Scott Kelly , ... to spend a year living and working on the International ... 5:30 to 7 a.m. EDT Monday, March 9. ... he completes the final weeks of his training. The interviews ... NASA Television highlighting his mission training and previous spaceflights. ...
Breaking Biology Technology:AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 2Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 3Focus on Quantifying Nucleic Acid Molecules Spurs Growth in the qPCR & dPCR Instrumentation Market, According to a New Report by Global Industry Analysts, Inc. 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 2Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 3Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 4Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 5Philips stellt integrierte Bildgebungslösungen auf dem Europäischen Röntgenkongress 2015 vor 6NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2
... , NEW YORK , ... (OTC Bulletin Board: ILNS), a biopharmaceutical company focused ... ("AD"), announced today that several of its significant shareholders ... interim funding to the Company and assist the Company ...
... SILVER SPRING, Md. , and INDIANAPOLIS , Feb. ... United Therapeutics Corporation (Nasdaq: UTHR ), announced today that ... to pursue development of ImmuneWorks, lead compound, IW001, a purified ... Idiopathic Pulmonary Fibrosis (IPF) and Primary Graft Dysfunction (PGD) in ...
... , , NEW YORK , ... Vice President James C. Borel said he expects the ... in 2010 and increase pre-tax operating income margin across the seed, ... on customers and investing to meet their needs is paying off," ...
Cached Biology Technology:Intellect Neurosciences, Inc. Announces Preliminary Agreement with Significant Shareholders to Provide Interim Funding and Assist the Company in Efforts to Secure Additional Financing 2Intellect Neurosciences, Inc. Announces Preliminary Agreement with Significant Shareholders to Provide Interim Funding and Assist the Company in Efforts to Secure Additional Financing 3Intellect Neurosciences, Inc. Announces Preliminary Agreement with Significant Shareholders to Provide Interim Funding and Assist the Company in Efforts to Secure Additional Financing 4Lung Rx and ImmuneWorks Announce Collaboration in Idiopathic Pulmonary Fibrosis and Primary Graft Dysfunction 2Lung Rx and ImmuneWorks Announce Collaboration in Idiopathic Pulmonary Fibrosis and Primary Graft Dysfunction 3DuPont Expects Strong 2010 Agriculture & Nutrition Sales Growth, Margin Expansion 2DuPont Expects Strong 2010 Agriculture & Nutrition Sales Growth, Margin Expansion 3DuPont Expects Strong 2010 Agriculture & Nutrition Sales Growth, Margin Expansion 4DuPont Expects Strong 2010 Agriculture & Nutrition Sales Growth, Margin Expansion 5
(Date:3/2/2015)... March 2, 2015   Neurotechnology , a provider ... the SentiGaze Software Development Kit (SDK). The ... that use off-the-shelf webcams to track eye movements and ... a monitor. Heatmaps can be used for applications such ... online advertising. The SDK can also be used to ...
(Date:2/24/2015)... 2015 Research and Markets ( ... "Global 2D Gesture Recognition Market 2015-2019" ... analysts forecast the Global 2D Gesture Recognition market ... the period 2014-2019 The increased demand ... one of the major trends in the market. ...
(Date:2/13/2015)... ACT Genomics Co., Ltd., a cancer ... cancer genomic information into precision diagnosis and personalized ... US$ 8 million in the its first private funding ... Taiwan , ACT Genomics has developed comprehensive ... to implement next generation sequencing (NGS) and multiplex ...
Breaking Biology News(10 mins):Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3Global 2D Gesture Recognition Market 2015-2019 with Cognitec Systems, CogniVue, eyeSight Mobile Technologies & PointGrab Dominating 2ACT Genomics Raises $8 Million in its First Private Funding Round 2
... million grant from the National Science Foundation to lead ... agricultural crop plants able to withstand drought conditions. The ... plant ( Brassica napus ). Canola is an important ... production. June Kwak, associate professor of cell biology and ...
... AVIV, Israel - European business leaders and high-level representatives ... entrepreneurs and industries, will gather in Tel Aviv during ... the first event in Israel under the Israeli EUREKA ... of the EUREKA Network and will provide European industries ...
... HILL, Mass. (10/25/2010) The development and first use ... mosquito have established 400,000 genetic markers capable of revealing ... insecticides and other preventive measures, according to findings published ... . The SNP array,s snapshot of the Anopheles ...
Cached Biology News:UMD to lead $5 million NSF-funded research partnership to develop drought-tolerant canola crops 2UMD to lead $5 million NSF-funded research partnership to develop drought-tolerant canola crops 3Israeli Minister of Industry and Trade to address European R&D leaders in Tel Aviv 2Genetic markers offer new clues about how malaria mosquitoes evade eradication 2Genetic markers offer new clues about how malaria mosquitoes evade eradication 3
... of long double stranded RNA (dsRNA) has ... a diverse group of organisms as well ... leads to the inhibition of protein expression ... target messenger RNA (mRNA). Attempts to induce ...
... in an easy-to-use benchtop package. Our ... (ESI-oa-TOF) concentrates the performance of a ... fits on your bench. The microTOFLC ... FWHM and mass accuracy of better ...
... Definitive Performance The TSQ Quantum ... excellence in bioanalytical and environmental analysis. ... ESI and APCI probes, a titanium skimmer ... increased robustness and sensitivity. Its redesigned ...
... uptake of long double stranded RNA (dsRNA) ... in a diverse group of organisms as ... interference leads to the inhibition of protein ... the target messenger RNA (mRNA). Attempts to ...
Biology Products: