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Stallergenes and Shionogi Sign Exclusive Partnership Agreements for Immunotherapy Tablets in Japan
Date:9/6/2010

y player in the allergy field. Shionogi & Co., Ltd., thanks to its strong allergy franchise and its well-established presence alongside allergy specialists, and Stallergenes will develop immunotherapy in Japan, particularly for house dust mite allergy, in which it has recently demonstrated its efficacy after 4 months of treatment and the persistence of its therapeutic effect after only one year of treatment," declared Albert Saporta, Stallergenes' Chairman and CEO.

ABOUT RESPIRATORY ALLERGY IN JAPAN

Allergic rhinitis affects 25%[1] of the population in Japan, and asthma 6.7%[2]. House dust mites and Japanese cedar pollen are the two main causes of respiratory allergies.

The Japanese allergy market is the 2nd biggest in the world behind the USA. There is a very strong - and as yet unmet - demand for allergy treatments in Japan.

ABOUT THE STALAIR(R) PROGRAM

Stalair(R) is the name of the pharmaceutical and clinical development program for immunotherapy tablets being implemented by Stallergenes with a view to obtaining marketing authorizations for pharmaceutical products in Europe and in other strategic markets.

The Stalair(R) development program includes 5 immunotherapy tablets: Oralair(R) (grass pollen), Actair(R) (house dust mites), r Bet v 1 (birch pollen recombinant allergen), ragweed pollen and Japanese cedar pollen.

Oralair(R) is the first project resulting from this program. A Mutual Recognition Procedure has been completed in Europe. Oralair(R), which is already marketed in Germany, will be launched in the fall in the Netherlands, the Czech Republic, Slovakia and Austria. Having recently demonstrated its efficacy after 3 years of treatment (study VO53.06 conducted in Europe), Oralair(R) has been the subject of a positive phase III trial in adults in the United States (VO61.08).

The second project in the program is Actair(R), house dust mite immunotherapy tablet. Having recently demonstrated Act
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Related biology technology :

1. STALLERGENES : Sales Guidance Exceeded : EUR193 Million, up 13%
2. STALLERGENES is Granted a Marketing Authorization for Oralair(R) in Europe
3. STALLERGENES: Immunotherapy Tablet Containing Recombinant Allergen (rBet v 1) of Birch Pollen: Positive Results for a Phase IIb/III Trial
4. STALLERGENES: 1st Half-Year 2009: Performance Ahead of Expectations
5. STALLERGENES: Strong Sales Growth in 1st Half-Year: up 12% Full-Year Guidance Maintained
6. Stallergenes : Investor Meeting: Webcast is Available
7. STALLERGENES: 2008: Strong Performance
8. Stallergenes Signs an Exclusive Partnership Agreement With Solvay Pharmaceuticals for the Promotion and Distribution of its Products in Russia and the CIS*
9. Stallergenes: 2008: Sales Up 16% - Excellent Performance - Guidance Exceeded
10. Stallergenes: Launch of a Phase III Clinical Trial in Adults for Oralair(R) Grasses in the United States Operating Income Expected to Remain Stable in 2009
11. Stallergenes: Sales at end September 2008: + 17% - 2008 Sales Guidance Revised Upwards: + 14%
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