The underlying cause of heart attack, stroke and PAD
Atherothrombosis occurs when a blood clot (thrombus) forms on a ruptured plaque (atheroma) in the wall of a blood vessel. Plaques consist of fatty acids and cholesterol, calcium and other materials.
The rupture of plaques and the subsequent development of a clot can cause partial or complete blockage of an artery in various parts of the body. When a vessel in the heart is partially or completely blocked by a clot the result can be a heart attack. In the brain, the same process can cause a stroke or a TIA which may only last a few minutes. Elsewhere in the body, this process can lead to reduction or blockage of blood flow in the arteries of the legs -- PAD -- a significant risk factor for heart attack or stroke.
Atherothrombosis is thus the common thread linking heart attack, stroke
Notes to Editors:
The REACH Registry is the first outpatient registry to characterize real-world event rates and treatment patterns in a broad spectrum of patients with atherothrombosis worldwide. The Registry follows more than 60,000 patients over four years, involving 44 countries and 5,000 physician investigators. The REACH Registry aims to improve the assessment and management of patients with a history of CAD, CVD (stroke/TIA), PAD, and those with a high combination of risk factors.
The REACH Registry is sponsored by sanofi-aventis, Bristol-Myers
Squibb, and the Waksman Foundation (Tokyo, Japan), who assisted with the
design and conduct of the study and data collection.
The REACH Registry is endorsed by the World Heart Federation.
REACH Registry Scientific Committee:
-- Philippe Gabriel Steg, Hopital Bichat-Claude Bernard, Paris, France
-- Deepak L. Bhatt, Cleveland Clinic Foundation, Cleveland, USA
-- E. Magnus Ohman, Duke University, Durham, NC, USA
-- Joachim Rother, Klinikum Minden, Hannover Medic
|SOURCE REACH Registry|
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