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Spherix Signs Research Contract With a Leading Global Contract Research Organization to Investigate Role of D-tagatose in Lowering Triglycerides
Date:12/8/2010

BETHESDA, Md., Dec. 8, 2010 /PRNewswire/ -- Spherix Incorporated (Nasdaq: SPEX), an innovator in biotechnology for therapy in diabetes, metabolic syndrome and atherosclerosis; and providers of technical and regulatory consulting services to food, supplement, biotechnology and pharmaceutical companies, today announced the signing of a multi-unit research contract between its wholly-owned subsidiary, Biospherics Incorporated, and a leading global contract research organization (CRO) to investigate the role of D-tagatose in lowering triglycerides. Work will begin immediately and continue through at least 2011.

"We are optimistic about the potential of D-tagatose to lower triglyceride levels and therefore we are investing in an aggressive drug development program," said Dr. Claire Kruger, Chief Executive Officer of Spherix. "The market for triglyceride-lowering drugs is robust, and exceeds $3 billion annually in the United States. We believe that, should our studies be successful, there will be an important role for D-tagatose to play in the treatment regimen."

As previously announced, Biospherics is developing a program to investigate the potential triglyceride-lowering effects of D-tagatose. In the first phase of this program, Biospherics is working with the CRO to design and execute studies in cell culture, animal models, and humans to clarify the mechanism of action of D-tagatose in modulating triglycerides and glucose in the metabolic syndrome. Importantly, as previously announced, the first post-hoc analysis of the Phase 3 NEET clinical trial with D-tagatose for the treatment of Type 2 diabetes provided information that supports the role of adipocytes (fat cells) in the mechanism of action for D-tagatose. This information on potential mechanism of action will be incorporated into the development program.

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