Navigation Links
Sorrento Therapeutics Presents Preclinical Data of its Fully Human Antibody Programs Targeting Anti-PD-L1 and Anti-PD-1 at the 8th Annual Next Generation Protein Therapeutics Summit
Date:6/24/2013

SAN DIEGO, June 24, 2013 /PRNewswire/ -- Sorrento Therapeutics, Inc. (OTCQB: SRNE; Sorrento) announced today that preclinical data of its therapeutic fully human anti-PD-L1 and anti-PD-1 monoclonal antibodies (mAbs) will be presented at the IBC 8th Annual Next Generation Protein Therapeutics Summit, June 26 - 28 in San Diego.

In recent clinical studies,[1] immunomodulatory anti-PD-1 and anti-PD-L1 antibodies have shown great promise for the treatment of solid tumors. By blocking immunosuppressive signals on cancer cells directed against infiltrating T cells, the patients' anti-tumor immune response might be rejuvenated.

"We believe these preclinical data are the first demonstration of potent immunomodulatory anti-PD-L1 and anti-PD-1 antibodies obtained from a fully human antibody library rather than mouse-based technologies," said Henry Ji, Ph.D., Sorrento's President and CEO. "Overall, these data illustrate the potential of Sorrento's G-MAB® library technology for discovery and development of fully human therapeutic antibodies against clinically valuable drug targets,"

The poster presentation titled "Human anti-PD-L1 and anti-PD-1 mAbs Identified from an Antibody Library Exhibit Potent Immune Cell Activation" is authored by J. Dixon Gray, Heyue Zhou, Edwige Gros, Kimberly Johnson, Gunnar F. Kaufmann, and Randy Gastwirt.

About Sorrento Therapeutics, Inc.

Sorrento Therapeutics, Inc. is a publicly-traded, development-stage biopharmaceutical company engaged in the discovery, acquisition, development and commercialization of proprietary drug therapeutics for addressing significant unmet medical needs in the Unites States, Europe and additional international markets. Sorrento Therapeutics' primary therapeutic focus is oncology but it is also developing therapeutics products for other indications, including inflammation, metabolic, and infectious diseases. Sorrento Therapeutics' proprietary G-MAB® fully-human antibody library platform was designed to facilitate the rapid identification and isolation of highly specific antibody therapeutic product candidates that bind to disease targets appropriate for antibody therapy.

More information is available at www.sorrentotherapeutics.com

Forward-Looking Statements

This press release contains forward-looking statements subject to risks and uncertainties that could cause actual results to differ materially from those projected. Words such as "assumes," "plans," "believes," "expects," "anticipates," and "will," and similar expressions, are intended to identify forward-looking statements. Forward-looking statements include statements about the clinical trial results from third parties, and the preclinical and clinical development of Sorrento's human antibody therapeutics. All such forward-looking statements are based on Sorrento's current beliefs and expectations, and should not be regarded as a representation by Sorrento that any of its plans will be achieved. Actual results may differ materially from those set forth in this press release due to the risks and uncertainties inherent in Sorrento's businesses; the scope and validity of patent protection for Sorrento's platform technologies, and the risk that the development or commercialization of product candidates may infringe the intellectual property rights of others; the potential that Sorrento may require substantial additional funding in order to obtain regulatory approval for and commercialize Sorrento Therapeutics' proprietary G-MAB® fully-human antibody library platform technologies or product candidates; and additional risks set forth in Sorrento Therapeutics' filings with the Securities and Exchange Commission. These forward-looking statements represent Sorrento Therapeutics' judgment as of the date of this release. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement and STI undertakes no obligation to revise or update this press release to reflect events or circumstances after the date hereof. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.

[1] Topalian, SL et al New England Journal of Medicine (http://www.nejm.org/doi/full/10.1056/NEJMoa1200690)

Brahmer JR et al; New England Journal of Medicine (http://www.nejm.org/doi/full/10.1056/NEJMoa1200694)

Hamid O et al; New England Journal of Medicine (http://www.nejm.org/doi/full/10.1056/NEJMoa1305133)


'/>"/>
SOURCE Sorrento Therapeutics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. Frost & Sullivan Presents bitop AG with the 2013 New Product Innovation Award in the Extremolytes Therapeutics Market
2. Injectable Drug Delivery Market by Formulations, Devices & Therapeutics - Global Forecasts to 2017
3. North America Injectable Drug Delivery Market - by Formulations, Devices & Therapeutics- Forecasts to 2017
4. Case Western Reserve University, in Collaboration with NDI Medical, SPR Therapeutics and Valtronic Technologies, Receives $3 Million from Ohio Third Frontier Commission
5. Mast Therapeutics Prices Public Offering Of Units
6. Closed Drug Transfer Systems: Oncology Therapeutics Market Dynamics and Closed Drug Transfer Design Factors - Market Forecasts to 2017
7. PTC Therapeutics Appoints Shane Kovacs as Chief Financial Officer
8. Industry Leader John Reynders Joins Moderna Therapeutics as Chief Information Officer
9. Flexion Therapeutics Names Frederick Driscoll Chief Financial Officer
10. Cell Therapeutics to Present at Upcoming Investor Conferences
11. Orexigen Therapeutics to Present at the Bank of America Merrill Lynch 2013 Health Care Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/4/2016)... , February 4, 2016 - New FDA action date ... New FDA action date of July 22, ... July 22, 2016   - Lifitegrast ... the past decade indicated for the treatment of signs and symptoms of ... has the potential to be the only product approved in the U.S. in the ...
(Date:2/4/2016)... ... February 04, 2016 , ... ... by Bloomsburg University’s Digital Forensics Club, takes place February 5-6 at the ... features 20+ speakers and activities such as workshops and competitions for ample ...
(Date:2/4/2016)... British Columbia and MENLO PARK, Calif. ... (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical company ... today announced that it will present at the 18 ... Monday, February 8, 2016 at 10:00 a.m. EST in ... Bacha , DelMar,s president and CEO, will provide an update ...
(Date:2/4/2016)... Feb. 4, 2016  Spherix Incorporated (Nasdaq: SPEX ... and monetization of intellectual property, today provided an update ... the Northern District of Texas ... Inter Partes Re-examination ("IPR") proceedings that ... The IPR was initiated on only certain claims of ...
Breaking Biology Technology:
(Date:2/4/2016)... 4, 2016 The field of Human ... the most popular hubs of the biotechnology industry. ... huge studies of human microbiota, have garnered a ... the microbiome space has literally exploded in terms ... This report focuses on biomedical aspects of research, ...
(Date:2/3/2016)... PUNE, India , February 3, 2016 ... to the new market research report "Automated Fingerprint Identification ... (Tenprint Search, Latent Search), Application (Banking & Finance, Government, ... 2020", published by MarketsandMarkets, the market is expected to ... estimated CAGR of 21.0% between 2015 and 2020. The ...
(Date:2/3/2016)... Feb. 3, 2016 ... of the "Emotion Detection and Recognition ... and Others), Software Tools (Facial Expression, Voice ... Users,and Regions - Global forecast to 2020" ... --> http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the ...
Breaking Biology News(10 mins):