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Sorrento Therapeutics' Innovative Approach to Developing Vaccines and Therapeutics for MRSA Receives Continued Support From the National Institute of Allergy and Infectious Diseases
Date:7/1/2011

the Company obtained an exclusive license to TSRI's quorum quenching technology, which lays the scientific foundation for this program.

"We believe that the use of quorum sensing signal molecules as targets for the development of vaccines and antibody therapeutics using our proprietary technology platform is a novel and promising approach to combat a serious public health issue. We look forward to working with our colleagues at Sorrento Therapeutics, Scripps and Montana State University in developing novel antibody therapeutics and vaccines against MRSA," said Dr. Kim Janda, Board member of Sorrento Therapeutics and Professor at TSRI.

For 2005, the Centers for Disease Control and Prevention estimated that 94,000 serious invasive MRSA infections occurred in the U.S. and more than 19,000 Americans died from these infections - more than from HIV/AIDS. A recent (2009) study from Duke University Medical Center looking at MRSA infections associated with surgery found a 35-fold increased risk of hospital readmission, a 7-fold increased risk of death, and more than $60,000 of additional charges per patient compared to uninfected controls. IMS Health reported that U.S. sales of antibiotics to treat MRSA exceeded $1 billion in 2007. Although a report from the Government Accounting Office indicates that no federal agency adequately monitors antibiotic resistance or evaluates its social and financial costs, various estimates place the annual cost to the healthcare system as high as $5 billion.

About the Sorrento Therapeutics MRSA Program

Sorrento Therapeutics has obtained an exclusive, worldwide license from TSRI to use this novel quorum sensing technology to identify fully human antibodies for the neutralization of Staph-specific signaling peptides that control bacterial virulence.  A research group at TSRI has shown that sequestering these signaling peptides, which are integral components of a bacterial communication process called quo
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SOURCE Sorrento Therapeutics, Inc.
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