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Sopherion Therapeutics, LLC Announces Publication of Phase I/II Myocet(R) (Nonpegylated Liposomal Doxorubicin) Data in Advanced Breast Cancer Patients
Date:2/5/2009

on (57.4%), asthenia (51.8%) and nausea (50%). Only two patients went off study due to "dermatitis".

About Myocet(TM) (Nonpegylated Liposomal Doxorubicin)

Myocet is a liposome-encapsulated doxorubicin-citrate complex. By encapsulating doxorubicin in a liposome - a manufactured, microscopic, vesicle consisting of discreet aqueous compartments surrounded by membranes composed of naturally occurring fats - its distribution in the body is altered in such a way as to reduce doxorubicin's toxicity. Extensive clinical studies of Myocet in women with breast cancer have shown that the cardiac toxicity of doxorubicin can be significantly reduced, while the efficacy of the drug is maintained. This delivery system does not encompass pegylation and yields very little hand foot syndrome.

The results of the SOLTI study further support an ongoing registration trial in patients with metastatic HER-2-overexpressing breast cancer, sponsored by Sopherion Therapeutics, LLC. This is a pivotal Phase III trial of Myocet(TM), paclitaxel and trastuzumab vs. paclitaxel and trastuzumab that uses progression-free survival as the primary efficacy endpoint, with careful monitoring for cardiac safety.

About Sopherion Therapeutics, LLC

Sopherion Therapeutics, LLC, is a privately-held biotechnology company based in Princeton, New Jersey. The Company is focused on developing novel anti-cancer therapies for patients suffering with advanced cancer, particularly metastatic disease. Sopherion is dedicated to the acquisition, discovery, development and commercialization of novel anti-cancer therapies with unique therapeutic activities that address unmet medical needs in and extend human life. In 2004, Sopherion entered into an exclusive licensing agreement with Zeneus Pharma Ltd. (now Cephalon, Inc.) for the future commercialization of Myocet in North America. For more information, visit

SOURCE Sopherion Therapeutics, LLC
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