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Sonus Pharmaceuticals and OncoGenex Technologies to Merge
Date:5/28/2008

rtunity for shareholders."

"We were attracted by the immediate value and the potential future value this transaction creates for Sonus and OncoGenex shareholders," said Mr. Cormack. "Our companies are built around very similar approaches to developing oncology products that provide better therapeutic alternatives for cancer patients. This transaction provides an exciting opportunity for the stockholders of both companies to realize the full value of each company's assets."

The combined company will have a deep oncology pipeline, with each product candidate having a distinct mechanism of action and representing a unique opportunity for cancer drug development. In addition to OGX-011, the pipeline includes two product candidates in Phase 1, and one additional product candidate that the company anticipates will move into Phase 1 clinical development within 18 months. Details on the specific products follow:

- OGX-011, also known as custirsen sodium, inhibits the production of

clusterin, a protein that is associated with treatment resistance in

a number of solid tumors, including prostate, breast, non-small cell

lung, ovarian, and bladder cancers. It has potential applicability as

a therapeutic in a broad number of cancers at different stages and

can potentially be used in combination with a variety of commonly

used cancer treatments, including chemotherapy, radiation therapy,

and hormone ablation therapy. Preliminary data in a Phase 2 clinical

trial evaluating OGX-011 in combination with second-line chemotherapy

in patients with hormone refractory prostate cancer has shown that

retreatment with docetaxel in combination with OGX-011 may reverse

docetaxel resistance and improve survival. OGX-011 is planned to

enter randomized clinical trials in patients with hormone refractory

prostate cancer that will support a N
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SOURCE OncoGenex Technologies Inc.
Copyright©2008 PR Newswire.
All rights reserved

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