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Some brain tumors mimic the genetic program of germline cells
Date:2/16/2011

% of them were responsible for functions related to germline cells. "These results show that these tumours mimic the gene expression profiles of germline cells", explains Ana Janic, first author of the study and PhD student in Gonzlez's lab.

Germline genes contribute to tumour growth

When the scientists studied the possible role of these specific genes of the germinal cell line in tumour expansion, they observed that by the silencing four lead to the development of healthy brains. "These experiments demonstrate that these genes are crucial for the development of this kind of tumour", states Janic.

Data collected over the last ten years indicate that the cancer cells of some tumours, such as melanomas and some kinds of carcinoma, activate genes of the germinal cell line. One possible diagnostic approach derived from these studies would be to use some of the proteins produced by these genes as tumour cell markers. In this context, the use of these proteins to make cancer vaccines is of particular relevance. This study sheds new light on the role of these proteins in the pathogenesis of cancer and opens up the way for new lines of research for the development of treatment against this disease in humans.


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Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

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