Navigation Links
Some brain tumors mimic the genetic program of germline cells
Date:2/16/2011

Scientists at IRB Barcelona have discovered that some brain tumours in larvae of the fruit fly Drosophila melanogaster use the genetic programme of germline cells to grow. The removal of some of these genes leads to healthy brains. This finding demonstrates that these genes are crucial for tumour development. The study, headed by ICREA researcher Cayetano Gonzlez, is published today in the prestigious journal Science.

One of the characteristics of tumour cells is their immortality, a property that allows them to divide without obeying external signals. As a result, tissue masses form, which, in most cases, interfere with organ functions. Data collected in recent years reveal than many human tumours activate specific genes of the germinal cell line those specialized in spermatozoids or ovules -, which is thought to allow them greater and longer viability. However, the role of these genes in tumour development remains to be established. In this study, the scientists showed for the first time that silencing some of these genes leads to the disappearance of tumours in the brain of the fruit fly.

Global analysis of gene expression in tumours

Not all cells use the same genes, but they make use of them depending on the function to be performed. This gene activation profile is what determines how cells divide and what they become specialized in, in the case they have not already done so. In this study the researchers have used DNA chip technology to monitor this gene activity in tumour cells and have compared it with healthy cells. For this purpose, they have analysed brain tumours induced by an alteration in the gene l[3]mbt in fruit fly larvae.

Analysis of the gene expression profiles indicates that these tumour cells activate a total of 102 genes that are not activated in healthy cells. When the researchers examined the functions of these genes they observed that, in many cases, they were unknown, although 25% of them were responsible for functions related to germline cells. "These results show that these tumours mimic the gene expression profiles of germline cells", explains Ana Janic, first author of the study and PhD student in Gonzlez's lab.

Germline genes contribute to tumour growth

When the scientists studied the possible role of these specific genes of the germinal cell line in tumour expansion, they observed that by the silencing four lead to the development of healthy brains. "These experiments demonstrate that these genes are crucial for the development of this kind of tumour", states Janic.

Data collected over the last ten years indicate that the cancer cells of some tumours, such as melanomas and some kinds of carcinoma, activate genes of the germinal cell line. One possible diagnostic approach derived from these studies would be to use some of the proteins produced by these genes as tumour cell markers. In this context, the use of these proteins to make cancer vaccines is of particular relevance. This study sheds new light on the role of these proteins in the pathogenesis of cancer and opens up the way for new lines of research for the development of treatment against this disease in humans.


'/>"/>

Contact: Nuria Noriega
nuria.noriega@irbbarcelona.org
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert

Related biology technology :

1. Ceregene Reports New Findings Regarding How Parkinsons Brains Respond to Neurotrophic Factors
2. New Method of Nutrition to Permanently Protect Brain Cells from Genetic Damage
3. Robot arm improves performance of brain-controlled device
4. Virtual reality helps researchers track how brain responds to surroundings
5. Neuro-Biotech Corp. Neuroceuticals® : A solution to feed the brain
6. Boston Scientific Begins Patient Enrollment in Clinical Trial Assessing Deep Brain Stimulation for Parkinsons Disease
7. Stone Age humans needed more brain power to make big leap in tool design
8. Elseviers BrainNavigator 3.0 Reflects the Next Step in Enhancing Neurological Research
9. Neurogenetic studies show proprietary compound reduces brain plaques linked to Alzheimers
10. Brain scans may help guide career choice
11. New Report Finds A Brain Health Revolution in the Making, Driven by Digital Technology and Neuroplasticity Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... 23, 2016  Blueprint Bio, a company dedicated to ... medical community, has closed its Series A funding round, ... "We have received a commitment from Forentis ... need to meet our current goals," stated Matthew ... runway to complete validation on the current projects in ...
Breaking Biology Technology:
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
Breaking Biology News(10 mins):