Navigation Links
Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH
Date:12/9/2008

, Bradford, United Kingdom.

Using data from the Phase III TRIUMPH study of Soliris, Dr. Hill and her colleagues evaluated the efficacy of Soliris in the regulation of cell-free plasma hemoglobin levels, nitric oxide depletion and subsequent cardiovascular morbidities in patients with PNH. This analysis found that 47 percent of patients with PNH (34 of 73) suffered from pulmonary hypertension before starting the trial. In this study, PAH was measured by an elevated blood level of NT-proBNP, which has been shown to be highly predictive of PAH and an independent predictor of mortality in other hemolytic diseases. (2) At the start of the study, levels of hemolysis and nitric oxide consumption were shown to be much greater in PNH (more than 6- and 10-fold, respectively) than in patients with other hemolytic diseases.

Patients treated with Soliris experienced a 50 percent reduction in the incidence of PAH over the course of the 26-week treatment period, from 52.5 percent to 26.3 percent, while PAH did not change with placebo (39.4% to 43.8%) (P<0.001). Additionally, Soliris-treated PNH patients experienced significantly improved shortness of breath compared to placebo, as measured by the EORTC QLQ-C30 quality of life survey (P<0.001).

"A careful analysis of blood levels in PNH patients shows that hemolysis, the red blood cell destruction that defines the disease, consumes nitric oxide in the blood which is likely to result in an increase in cardiovascular complications as shown in other hemolytic diseases," said Dr. Hill. "This study confirms that PAH is common in hemolytic PNH patients and also suggests that the anti-hemolytic effect of Soliris treatment significantly increases nitric oxide and consequently reduces pulmonary hypertension in patients with PNH."

Pulmonary artery hypertension is a rare, progressive disorder characterized by high blood pressure (hypertension) of the pulmon
'/>"/>

SOURCE Alexion Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related biology technology :

1. Alexions Soliris(R) Receives 2008 Prix Galien USA Award for Best Biotechnology Product
2. Alexion Acquires All Rights to OMRF Patents Related to Soliris(R)
3. Treatment with Paliperidone ER May Be Associated with Significantly Reduced Use of Mental Health Resources
4. Insmed President Interviewed for Follow-On Biologics Podcast: Insmed Inc. President Steve Glover Discusses Safe and Effective Biologic Therapies and Reduced Costs with The American Magazine
5. New Phase 3 Data Showed PRISTIQ Significantly Reduced Symptoms of Major Depressive Disorder Versus Placebo
6. UCB Announces New Data Showing Investigational Drug Lacosamide Significantly Reduced Seizures in Refractory Epilepsy Patients
7. Study Data Results Showed Desvenlafaxine Significantly Reduced Moderate to Severe Vasomotor Symptoms in Menopausal Women Versus Placebo
8. Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy
9. PharmAthene Signs Agreement with Medison Pharma Ltd. to Commercialize and Distribute Biodefense Medical Countermeasures in Israel
10. NIST studies how new helium ion microscope measures up
11. SpectraCell Laboratories Now Measures Vitamin C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 22, 2015 Crystal Diagnostics (CDx) Xpress ... it has received AOAC-PTM Certifications for the six non-O157 Shiga ... O145; collectively referred to as STEC or the “Big-6”) as ... forming unit (cfu) per 325 g of raw ground beef ...
(Date:1/22/2015)... zFlo Motion , a US leader ... exciting product from a new partner. STT-Systems has ... past 15 years, with offerings in the optical-motion capture, 3D ... system (inertial measurement unit), iSen, is opening eyes around the ...
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
(Date:1/22/2015)... 22, 2015 Diagenode, Inc., a ... the Bioruptor® and complete solutions for epigenetics research, ... immunoprecipitation, alleviating the need for manual processing. The ... for ChIP of histones or transcription factors and ...
Breaking Biology Technology:Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 23D Motion Capture Just Got Easy 2Global Compliance Service for Controlled Substances to Expand to China 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... of Roche Diagnostics, North America, Has 25 Years of Life ... Sciences Industry ... KOOL ), a leading supplier of innovative products that,process and store ... Chief Executive Officer, Roche Diagnostics,Corporation, North America, has been named to ...
... with Company Estimates Highlighted by 11% Discovery ... Products and Services Growth -, ... ) today reported second quarter financial,results for 2008. Revenues were $34.0 ... quarter of $35.3 million. Revenues were impacted,by a $3.5 million decline ...
... ISLAND, S.C., Aug. 6 Denham Capital,("Denham") ... to $60 million in VitAG,Corporation ("VitAG"). VitAG ... fertilizer product capable of competing with and,outperforming ... of multiple biosolids-to-fertilizer manufacturing plants., "Denham,s ...
Cached Biology Technology:ThermoGenesis Names Tiffany Olson to Board of Directors 2ThermoGenesis Names Tiffany Olson to Board of Directors 3Caliper Life Sciences Reports Second Quarter 2008 Results 2Caliper Life Sciences Reports Second Quarter 2008 Results 3Caliper Life Sciences Reports Second Quarter 2008 Results 4Caliper Life Sciences Reports Second Quarter 2008 Results 5Caliper Life Sciences Reports Second Quarter 2008 Results 6Caliper Life Sciences Reports Second Quarter 2008 Results 7Caliper Life Sciences Reports Second Quarter 2008 Results 8Caliper Life Sciences Reports Second Quarter 2008 Results 9Denham Capital to Invest $60 Million in VitAG, Recycler of Municipal Biosolids 2
(Date:1/22/2015)... YORK , Jan. 22, 2015   EyeLock, Inc. , ... it has appointed Steve Gerber to the new ... will be responsible for leading development of mobile platforms and ... years of success and innovation in the semiconductor industry to ...
(Date:12/22/2014)... 2014  The 2014 Holiday Season may be the brightest ... reports that the long anticipated floodgates for consumer biometrics ... for smart phones, tablets, and wearable mobile devices that ... billion users with nearly 4.8 billion biometric devices by ...
(Date:12/17/2014)... 15, 2014 Research and Markets ( http://www.researchandmarkets.com/research/s6qzt5/samsung_galaxy_s5 ... Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology ... http://photos.prnewswire.com/prnh/20130307/600769 Based on a ... introduces for the first time a fingerprint sensor in ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... organic farming becomes more common, methods to identify ... a recent study in Journal of Environmental Quality, ... if non-organic, synthetic fertilizers were used on sweet ... de Investigacin y Desarrollo Agrario y Agrario y ...
... REM sleep deprivation procedure reduces cell proliferation in the ... of rats, according to a study published in the ... study, authored by Dennis McGinty, PhD, of the V.A. ... rats. REM sleep deprivation was achieved by a ...
... of Southern California have developed a prostate cancer vaccine ... of young mice genetically predestined to develop the disease. ... they suggest the same strategy might work for men ... potential diagnostic indicator of prostate cancer. By ...
Cached Biology News:Is it organic or not? 24 days of REM sleep deprivation contributes to a reduction of cell proliferation in rats 2Prostate cancer: Watchful wait or vaccinate? 2Prostate cancer: Watchful wait or vaccinate? 3
Rabbit Anti-conjugated Agmatine Polyclonal Antibody...
ABCA1 Immunogen: Mouse ABCA1-expressing HeLa stable transfectants. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... ADAMTS16 ( Abpromise for all ... Synthetic peptide based on the ... the amino acid sequence is proprietary) ... 170690 SWISS Protein ...
Goat polyclonal to SART3 ( Abpromise for all tested applications). Antigen: Synthetic peptide: MSNADFAKLFLRK, corresponding to C terminal amino acids 951-963 of Human SART3 Entrez Gene ID: 9...
Biology Products: