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Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH
Date:12/9/2008

CHESHIRE, Conn., Dec. 9 /PRNewswire-FirstCall/ -- Soliris(R) (eculizumab), a terminal complement inhibitor developed by Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN), was observed by investigators to reduce blood measures associated with undiagnosed blood clots and inflammation in patients with PNH.

A separate study found that Soliris was observed to reduce indicators of pulmonary artery hypertension (PAH) in patients with paroxysmal nocturnal hemoglobinuria (PNH), according to a new analysis of clinical trial data. Both sets of data were presented in oral sessions yesterday at the 50th Annual Meeting of the American Society of Hematology.

"The common, severe and progressive clinical consequences of PNH are becoming more apparent as researchers gain more experience and basic knowledge with regard to this disease," said Leonard Bell, M.D., Chief Executive Officer of Alexion.

Blood Markers of Thrombin Generation and Inflammation

Research titled "Eculizumab Therapy Results in Rapid and Sustained Decreases in Markers of Thrombin Generation and Inflammation in Patients with PNH" was presented yesterday in an oral session at the ASH annual meeting by Ilene Ceil Weitz, M.D., Assistant Clinical Professor of Medicine, Jane Anne Nohl Division of Hematology, Keck School of Medicine of the University of Southern California.

Recently published research showed that patients with PNH were observed to have 92 percent fewer blood clots (thromboses) during treatment with Soliris (1) compared to the period of time prior to Soliris treatment. To better understand the mechanism for this observed reduction, researchers used highly sensitive laboratory tests to track levels of blood markers in order to determine the effect of Soliris on markers of thrombin generation and inflammation among ei
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SOURCE Alexion Pharmaceuticals, Inc.
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