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Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments
Date:3/27/2012

  • On January 31, 2012, the Company implemented a one-for-twenty reverse split of its common stock effective February 1, 2012.
  • On January 26, 2012, the Company announced the receipt of approximately $574,000, net of transaction costs, in non-dilutive financing via the State of New Jersey's Technology Business Tax Certificate Transfer Program.
  • On January 18, 2012, the Company announced results from long-term stability studies of its proprietary DNI (dominant negative inhibitor) anthrax rPA (recombinant protective antigen) subunit protein vaccine, known as SGX204. SGX204 is a hyperimmunogenic derivative of PA and is being developed as a vaccine to protect against anthrax disease either as a pre-exposure prophylactic vaccine or post-exposure vaccine. Positive stability was demonstrated when DNI rPA was subjected to temperatures as high as 70 degrees Celsius for one month.  In this case, DNI rPA retained native configuration with no evidence of denaturation that typically occurs in water buffers under the same thermal conditions. Redundant methods to determine protein structure each yielded results that indicated that the thermally stressed DNI protein retained completely native conformation after exposure to 70 degrees Celsius. The water free DNI protein was formulated with common excipients that allow for preservation of protein structure in the dried state. Long-term stability of DNI rPA was also demonstrated after refrigerated storage for more than 7 years. More importantly, when DNI rPA was combined with a potent adjuvant formulation, animals vaccinated with the combination developed high titer neutralizing antibodies that confer protection against anthrax disease. 
  • On December 12, 2011, the Company announced the publication of results from an investigator-initiated Phase 2 "proof-of-concept" exploratory clinical trial of orBec® for the prevention of acute Graft-versus-Host disease (GVHD) in patients undergoing myeloabl
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