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Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments
Date:3/27/2012

n acute GI GVHD at the recommendation of an independent Data Safety Monitoring Board. As a result of this event, we have restructured the organization by decreasing headcount with a continued focus on cash management and research and development program expenditures. We remain committed to evaluating all strategic options while we continue the development of our oral BDP programs for pediatric Crohn's disease, acute radiation syndrome and acute radiation enteritis as well as the development of our vaccine programs including our novel thermostabilization technology, ThermoVax™."

Soligenix's Recent Highlights:

  • On February 21, 2012, the Company announced further promising results from its continuing preclinical study of SGX202 (oral BDP) in a canine gastrointestinal acute radiation syndrome (GI ARS) model. The new study results indicate that dogs treated with SGX202 starting 24 hours after exposure to lethal doses of total body irradiation (TBI) demonstrated statistically significant (p=0.04) improvement in survival when compared to control dogs. This study builds upon the previous results which showed statistically significant survival in dogs when dosing of SGX202 was initiated two hours after lethal doses of TBI. These results demonstrate that SGX202 has the potential to reduce the inflammatory cytokine storm induced by the radiation damaged GI tract.
  • On February 10, 2012, the Company announced preliminary results from its Phase 1/2 clinical trial evaluating SGX201, a time-release formulation of oral BDP for the prevention of acute radiation enteritis. The Phase 1/2 protocol BDP-ENT-01 was designed as an open label, randomized, dose-finding study at five centers.  Sixteen subjects with rectal cancer scheduled to undergo concurrent radiation and chemotherapy prior to surgery were enrolled in one of four dose groups, with dosing administered throughout the duration of radiation therap
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Related biology technology :

1. Soligenix Announces 1 for 20 Reverse-Split of its Common Stock
2. Soligenix Reports First Quarter 2011 Financial Results and Reviews Accomplishments
3. Soligenix Reports Year-End 2010 Financial Results and Highlights Recent Accomplishments
4. Soligenix Receives FDA Orphan Drug Designation for RiVax™ for the Prevention of Ricin Intoxication
5. Soligenix Reports Second Quarter 2010 Financial Results and Reviews Accomplishments
6. Soligenix Announces Private Equity Financing of $5.16 Million With Its Partner Sigma-Tau and Other Institutional Investors
7. Soligenix Announces Grant of US Patent for the Treatment of Irritable Bowel Syndrome with Oral Beclomethasone Dipropionate
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9. Soligenix Announces Completion of Patient Enrollment in Phase 2 Acute GVHD Prevention Clinical Trial
10. Soligenix Announces Grant of Broad European Patent for Topically Active Steroids to Treat Inflammatory Gastrointestinal Disorders
11. Soligenix to Present at 12th Annual BIO CEO & Investor Conference
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