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Soligenix Announces Grant of US Patent for the Treatment of Irritable Bowel Syndrome with Oral Beclomethasone Dipropionate
Date:5/19/2010

ivity, respectively. Soligenix is also continuing to actively build intellectual property around oral BDP in other inflammatory conditions and has obtained orphan drug designation for the treatment of pediatric Crohn's Disease.

About Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder that affects the large intestine (colon).  IBS commonly causes cramping, abdominal pain, bloating gas, diarrhea and constipation and is generally very disruptive to daily living activities.  It is usually treated with anti-diarrheal agents such as loperamide, anticholinergic agents, and prokinetic agents.  IBS has been called spastic colon, functional bowel disease, and mucous colitis. IBS affects up to 55 million Americans, mostly women, and its causes are unknown.

IBS represents a therapeutic challenge to both clinicians and developers of pharmaceuticals. The uncertainty and variety of causes, as well as the variable nature of symptomatic expression greatly complicates the task of treating this disorder.  In IBS, the movement of the digestive tract does not work as it should, but there is no sign of changes in the intestines, such as inflammation or tumors. It is thought that IBS symptoms are related to problems with the signals sent between the brain and the intestines which in turn cause problems with the way the muscles of the intestines move.

About oral BDP

Beclomethasone dipropionate (BDP) is a highly potent, topically active corticosteroid that has a local effect on inflamed tissue. BDP has been marketed in the US and worldwide since the early 1970s as the active pharmaceutical ingredient in a nasal spray and in a metered-dose inhaler for the treatment of patients with allergic rhinitis and asthma. BDP is the active ingredient in
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SOURCE Soligenix, Inc.
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