Navigation Links
Sodium plays key role in tissue regeneration
Date:9/28/2010

MEDFORD/SOMERVILLE, Mass. Sodium gets a bad rap for contributing to hypertension and cardiovascular disease. Now biologists at Tufts University's School of Arts and Sciences have discovered that sodium also plays a key role in initiating a regenerative response after severe injury. The Tufts scientists have found a way to regenerate injured spinal cord and muscle by using small molecule drugs to trigger an influx of sodium ions into injured cells.

The approach breaks new ground in the field of biomedicine because it requires no gene therapy; can be administered after an injury has occurred and even after the wound has healed over; and is bioelectric, rather than chemically based.

In a paper appearing as the cover story of the September 29, 2010, issue of the Journal of Neuroscience, the Tufts team reported that a localized increase in sodium ions was necessary for young Xenopus laevis tadpoles to regenerate their tails complex appendages containing spinal cord, muscle and other tissue.

Like human beings, who regenerate fingertips only as children, these tadpoles lose the ability to regenerate their tail with age. Most remarkably, it was shown that such "refractory" tadpoles whose tails had been removed could be induced to make a perfect new tail by only an hour of treatment with a specific drug cocktail.

The findings have tremendous implications for treating wounds sustained in war as well as accidental injuries. The treatment method used is most directly applicable to spinal cord repair and limb loss, which are highly significant medical problems world-wide. It also demonstrates a proof-of-principle that may be applicable to many complex organs and tissues.

"We have significantly extended the effective treatment window, demonstrating that even after scar-like wound covering begins to form, control of physiological signals can still induce regeneration. Artificially causing an influx of sodium f
'/>"/>

Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Cerimon Pharmaceuticals Initiates Phase III Clinical Studies to Evaluate Its Topical Diclofenac Sodium Patch for Mild-to-Moderate Pain
2. Reportlinker Adds Diclofenac sodium (CAS 15307-79-6) Market Research Report 2009
3. TrueVision Adds 3D Flat Panel Displays to its Visualization Platform for Refractive-Cataract Surgery
4. DNA Genotek's Oragene●ANIMAL DNA Collection Kit Plays Key Role in Determining the Genetic Cause of Chiari Malformation in Dogs
5. Greenway Medical Technologies Plays Leading Role in Interoperability Demonstrations at Seventh Annual Public Health Information Network (PHIN) Conference
6. Simbionix ANGIO Mentor Plays Important Role in Physician Training and Certification
7. Copper nanowires enable bendable displays and solar cells
8. SpectraScience Awarded Patent for Its Optical Biopsy System and Methods for Tissue Diagnosis
9. CSMG Technologies Announces Key Fifth U.S. Tissue Bonding/Welding Patent Approved
10. Global Med Technologies(R), Inc. Partners With Biomedical Synergies to Offer Advanced Tissue Tracking Solutions for Hospitals and Surgery Centers
11. BioLife Solutions Submits FDA Master File on HypoThermosol(R) Preservation and Storage Media for Cells, Tissues
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sodium plays key role in tissue regeneration
(Date:8/27/2015)...  Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a leading ... today announced that executives from the company will present ... , Pedro Lichtinger , Chief ... Annual Global Investment Conference on Wednesday, September 10, 2015 ... in New York City . ...
(Date:8/27/2015)... Greifensee, Switzerland (PRWEB) , ... August 27, 2015 ... ... input on customers’ weighing needs and expertly narrows down the product choices to ... additional selection criteria pares down the list to models that fit best with ...
(Date:8/26/2015)... 26, 2015  Roka Bioscience, Inc. (NASDAQ: ROKA ... testing solutions for the detection of foodborne pathogens, today ... the Sidoti & Company Emerging Growth Conference on September ... at the New York Marriott Marquis. ... through the investor relations section of Roka Bioscience,s website ...
(Date:8/26/2015)... 26, 2015 Israel Proves Its Place in ... st place  Wayerz comes in 5 th ... by venture capital fund JVP, with Chinese consulting firm ... China , Israel , ... Impressive achievement for the Israeli representatives in the final round ...
Breaking Biology Technology:Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2METTLER TOLEDO Updates Online Scale Selection Tool 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6
... an explanation as to where and how North Sea oil ... be the first step on the way to developing improved ... from Danish oil fields. , A research group at the ... of Copenhagen has investigated drill cores collected from North Sea ...
... Apex Bioventures Acquisition Corporation (NYSE Amex: PEX ... notice from NYSE Amex LLC (the "Exchange") that the ... accepted by the Exchange and the Company has been ... compliance with the continued listing standards of the Exchange.As ...
... China, May 11 /PRNewswire-Asia-FirstCall/ -- China Sky One Medical,Inc. ... CSKI ), a leading,fully integrated pharmaceutical company producing ... announced that it will conduct a,conference call at 10:00 ... to discuss its first quarter of fiscal year 2009 ...
Cached Biology Technology:New Danish research shows how oil gets stuck underground 2Apex Bioventures Acquisition Corporation Receives Notice of Extension from NYSE Amex 2China Sky One Medical, Inc. Schedules Conference Call to Discuss First Quarter 2009 Results 2China Sky One Medical, Inc. Schedules Conference Call to Discuss First Quarter 2009 Results 3
(Date:8/5/2015)... Calif. , Aug. 5, 2015 The ... continuous growth in applications, penetration into newer sectors, and ... year. The global biosensors space has seen the entry ... the market so far. (Photo - ... & Sullivan, Analysis of the Global Biosensors Market ...
(Date:7/31/2015)... , Kina, 31. juli 2015 Den 10. ... afholdt af BGI fra den 22. - 25. oktober i ... Konferencen fejrer sin 10-års fødselsdag i år. Siden starten ... indflydelsesrige årlige møder på ,omik,-feltet, og er en af ... ICG-10 fokuserer på nylige gennembrud og fremskridt ...
(Date:7/31/2015)... , 31 de julio de 2015 La 10 ... se celebrará por medio de BGI del 22 al 25 de ... Este año, la conferencia celebra su décimo ... ha convertido en una de las reuniones anuales más influyentes ... de las reuniones más dinámicas, entusiastas y mejores a nivel ...
Breaking Biology News(10 mins):Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
... New Rochelle, NY, December 2, 2010 For ... addressed at the highest level of government. With the ... the U.S. Department of Health and Human Services has ... - and supporting breastfeeding is prominent among them. ...
... scientists at the University of Leicester have recorded stunning ... European Space Agency satellite instruments have been observing ... points in space. Leicester scientists have used ... images of a snow-bound UK from observations on November ...
... of Chicago Medical Center is designed to offer surgeons ... new molecular and mechanical solutions to three age-old problems: ... between blood vessels), improving tissue healing after surgery and ... The conference, "Solving the most challenging surgical ...
Cached Biology News:New public health goals tackle obstacles to breastfeeding success 2Snow from space: University of Leicester releases satellite images of snow-bound UK 2Conference goals include better surgery and better surgeons 2Conference goals include better surgery and better surgeons 3
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
TXNL2 Antibody...
Mouse monoclonal [3F8 ] to smooth muscle Myosin heavy chain I ( Abpromise for all tested applications). entrezGeneID: 4629 SwissProtID: P35749...
Request Info...
Biology Products: