Navigation Links
Smart insulin nanostructures pass feasibility test, UT study reports
Date:9/22/2007

HOUSTON -- (Sept. 18, 2007) -- Biomedical engineers at The University of Texas School of Health Information Sciences at Houston have announced pre-clinical test results in the September issue of the International Journal of Nanomedicine demonstrating the feasibility of a smart particle insulin release system that detects spikes in glucose or blood sugar levels and releases insulin to counteract them.

Designed to mimic functions of the pancreas which produces the blood-sugar regulating hormone insulin, the smart particle system stabilized blood sugar levels in animal models with suppressed pancreatic functions for up to six hours, researchers reported. It is an inhalable system.

The study, Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats, was conducted in the laboratory of Ananth V. Annapragada, Ph.D., an associate professor at the UT School of Health Information Sciences. Research assistant Efstathios Karathanasis was lead author and postdoctoral fellow Rohan C. Bhavane was a contributor on the article.

The smart particle system consists of a blood sugar sensing protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles, Annapragada said. When blood sugar becomes present, the Con A releases the particles to bind independently to the sugars. The released particles then release their insulin.

Hundreds of thousands of individuals suffer Type I diabetes, a condition that develops when the bodys immune system destroys pancreatic beta cells the only cells that make insulin. High blood sugar levels can lead to serious complications and premature death.

No one had ever shown that an inhalable smart release system was viable, said Annapragada, who describes the study as a proof of concept initiative. He said additional work including the discovery of less inflammatory blood sugar sensing proteins or small molecules will be required before its efficacy for patients can be tested in clinical trials.

The smart particle system could potentially treat other health conditions, he said.


'/>"/>

Contact: Rob Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related biology technology :

1. Are siRNA Pools Smart?
2. Treo 700w solves my smart phone woes
3. "Smart" lenses hold commercial potential
4. PDS debuts managed smartphone service
5. Promega spins off RFID smart appliance company
6. U.K. firm develops smart fabrics
7. Renaissance to buy computer companion maker AlphaSmart for $57m
8. UW Hospital and Clinics install smart intravenous pumps
9. Save money through smart patenting
10. Vertical partnering: Street smarts for a tough marketplace
11. Life Sciences: Wisconsin - The Smart Choice Part Two
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2017)... (PRWEB) , ... July 13, 2017 , ... ... linearity and calibration verification test kit has received US FDA 510 (k) clearance ... a human plasma matrix, evaluates D-Dimer. Each VALIDATE® D-Dimer kit, prepared using the ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... Thousands of ... and August for the National Aeromodeling Championships (Nats). Pilots come to Muncie to compete ... to earn spots on US teams that participate in world championships. , RC Pylon ...
(Date:7/13/2017)... ... July 13, 2017 , ... In’Tech Medical SAS ( http://www.intech-medical.com ... the completion of a major transaction with Eurazeo PME. The reputable French private ... alliance fuels In’Tech Medical’s service offerings while leveraging the company’s manufacturing expertise and ...
(Date:7/13/2017)... (PRWEB) , ... July 13, 2017 , ... ... Technology Center, Inc. (FITCI), has experienced robust growth in the past year after ... nonprofit has launched several Entrepreneurial Acceleration Programs and expanded its board of directors ...
Breaking Biology Technology:
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
Breaking Biology News(10 mins):