Navigation Links
Smart insulin nanostructures pass feasibility test, UT study reports
Date:9/22/2007

HOUSTON -- (Sept. 18, 2007) -- Biomedical engineers at The University of Texas School of Health Information Sciences at Houston have announced pre-clinical test results in the September issue of the International Journal of Nanomedicine demonstrating the feasibility of a smart particle insulin release system that detects spikes in glucose or blood sugar levels and releases insulin to counteract them.

Designed to mimic functions of the pancreas which produces the blood-sugar regulating hormone insulin, the smart particle system stabilized blood sugar levels in animal models with suppressed pancreatic functions for up to six hours, researchers reported. It is an inhalable system.

The study, Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats, was conducted in the laboratory of Ananth V. Annapragada, Ph.D., an associate professor at the UT School of Health Information Sciences. Research assistant Efstathios Karathanasis was lead author and postdoctoral fellow Rohan C. Bhavane was a contributor on the article.

The smart particle system consists of a blood sugar sensing protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles, Annapragada said. When blood sugar becomes present, the Con A releases the particles to bind independently to the sugars. The released particles then release their insulin.

Hundreds of thousands of individuals suffer Type I diabetes, a condition that develops when the bodys immune system destroys pancreatic beta cells the only cells that make insulin. High blood sugar levels can lead to serious complications and premature death.

No one had ever shown that an inhalable smart release system was viable, said Annapragada, who describes the study as a proof of concept initiative. He said additional work including the discovery of less inflammatory blood sugar sensing proteins or small molecules will be required before its efficacy for patients can be tested in clinical trials.

The smart particle system could potentially treat other health conditions, he said.


'/>"/>

Contact: Rob Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related biology technology :

1. Are siRNA Pools Smart?
2. Treo 700w solves my smart phone woes
3. "Smart" lenses hold commercial potential
4. PDS debuts managed smartphone service
5. Promega spins off RFID smart appliance company
6. U.K. firm develops smart fabrics
7. Renaissance to buy computer companion maker AlphaSmart for $57m
8. UW Hospital and Clinics install smart intravenous pumps
9. Save money through smart patenting
10. Vertical partnering: Street smarts for a tough marketplace
11. Life Sciences: Wisconsin - The Smart Choice Part Two
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit ... 7th and 8th June 2018 in San Francisco, CA. The Summit brings together current ... several distinguished CEOs, board directors and government officials from around the world to address ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new ... rates in frozen and fresh in vitro fertilization (IVF) transfer cycles. ... to IVF success. , After comparing the results from the fresh and frozen ...
(Date:10/10/2017)... California (PRWEB) , ... October 10, 2017 , ... Dr. ... speaking at his local San Diego Rotary Club. The event entitled ... Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology:
(Date:8/23/2017)... -- The general public,s help is being enlisted in what,s thought to be ... on the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study ... gut. The project's goal is to help advance scientific knowledge of the ... ...
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
Breaking Biology News(10 mins):