Navigation Links
Smart insulin nanostructures pass feasibility test, UT study reports
Date:9/22/2007

HOUSTON -- (Sept. 18, 2007) -- Biomedical engineers at The University of Texas School of Health Information Sciences at Houston have announced pre-clinical test results in the September issue of the International Journal of Nanomedicine demonstrating the feasibility of a smart particle insulin release system that detects spikes in glucose or blood sugar levels and releases insulin to counteract them.

Designed to mimic functions of the pancreas which produces the blood-sugar regulating hormone insulin, the smart particle system stabilized blood sugar levels in animal models with suppressed pancreatic functions for up to six hours, researchers reported. It is an inhalable system.

The study, Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats, was conducted in the laboratory of Ananth V. Annapragada, Ph.D., an associate professor at the UT School of Health Information Sciences. Research assistant Efstathios Karathanasis was lead author and postdoctoral fellow Rohan C. Bhavane was a contributor on the article.

The smart particle system consists of a blood sugar sensing protein named concanavalin A (Con A) and bundles of tiny fat bubbles called liposomes that are loaded with insulin. Con A binds insulin-containing liposomes that are coated with sugars, to each other, to form the inhaled particles, Annapragada said. When blood sugar becomes present, the Con A releases the particles to bind independently to the sugars. The released particles then release their insulin.

Hundreds of thousands of individuals suffer Type I diabetes, a condition that develops when the bodys immune system destroys pancreatic beta cells the only cells that make insulin. High blood sugar levels can lead to serious complications and premature death.

No one had ever shown that an inhalable smart release system was viable, said Annapragada, who describes the study as a proof of concept initiative. He said additional work including the discovery of less inflammatory blood sugar sensing proteins or small molecules will be required before its efficacy for patients can be tested in clinical trials.

The smart particle system could potentially treat other health conditions, he said.


'/>"/>

Contact: Rob Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert

Related biology technology :

1. Are siRNA Pools Smart?
2. Treo 700w solves my smart phone woes
3. "Smart" lenses hold commercial potential
4. PDS debuts managed smartphone service
5. Promega spins off RFID smart appliance company
6. U.K. firm develops smart fabrics
7. Renaissance to buy computer companion maker AlphaSmart for $57m
8. UW Hospital and Clinics install smart intravenous pumps
9. Save money through smart patenting
10. Vertical partnering: Street smarts for a tough marketplace
11. Life Sciences: Wisconsin - The Smart Choice Part Two
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... MENLO PARK, Calif., March 23, 2017  BioPharmX ... developing products for the dermatology market, today reported ... Jan. 31, 2017, and will provide an update ... from the year. "We are pleased ... productive year for BioPharmX," said President Anja Krammer. ...
(Date:3/23/2017)... 23, 2017  Agriculture technology company Cool Planet has ... note conversion to commercialize its Cool Terra and Cool ... developing products that are simultaneously profitable as well as ... last 18 months. This latest round of funding was ... The company,s primary product, Cool Terra, ...
(Date:3/22/2017)...  Ascendis Pharma A/S (Nasdaq: ASND), a biopharmaceutical ... address significant unmet medical needs in rare diseases, ... ended December 31, 2016. "2016 ... we broadened our pipeline and pursued our vision ... with an initial focus on endocrinology," said ...
(Date:3/22/2017)... 22, 2017 The global chronic ... research report by Transparency Market Research (TMR). The top ... and AbbVie Inc., accounted for a share of only ... in this market are focusing aggressively on mergers, acquisitions, ... is likely to lead to market consolidation in the ...
Breaking Biology Technology:
(Date:2/21/2017)... N.Y. and PORTLAND, Ore. ... ) and the Avamere Family of Companies (Avamere Health ... today announced a six-month research study that will apply ... improve eldercare at senior living and health centers. By ... Avamere hopes to gain insights into physical and environmental ...
(Date:2/13/2017)... 2017  RSA Conference -- RSA, a Dell Technologies ... to enhance fraud detection and investigation across digital ... Fraud & Risk Intelligence Suite. The new platform ... insights from internal and external sources as well ... customers from targeted cybercrime attacks. "Fraudsters ...
(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
Breaking Biology News(10 mins):