Navigation Links
Slow-release 'jelly' delivers drugs better
Date:1/28/2013

iram, former Chilkoti graduate student and first author on the paper, dubbed the new delivery system POD, for protease-operated depot.

In the latest experiments, published on-line in the journal Proceedings of the National Academy of Sciences, the researchers fused glucagon-like peptide-1 (GLP-1), a hormone that regulates the release of insulin, with a genetically engineered heat-sensitive polymer to create the POD.

"Remarkably, a single injection of the GLP-1 POD was able to reduce blood glucose levels in mice for up to five days, which is 120 times longer than an injection of the peptide alone," Chilkoti said. "For a patient with type 2 diabetes, it would be much more desirable to inject such a drug once a week or once a month rather than once or twice a day.

"Additionally, this approach avoids the peaks and valleys of drug concentrations that these patients often experience," Chilkoti said.

Unlike peptide-loaded microspheres, PODs are also easy to manufacture, because the peptide drug and the heat-sensitive polymer are all made of amino acids. They can be built as one long stretch of amino acids by engineered bacteria.

"This new delivery system provides the first entirely genetically encoded alternative to peptide drug encapsulation for sustained delivery of peptide drugs," Chilkoti said.


'/>"/>

Contact: Richard Merritt
richard.merritt@duke.edu
919-660-8414
Duke University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Jellyfish inspires latest ocean-powered robot
2. CEM President and CEO Delivers Commencement Address at the 2012 University of Texas at Austin Chemistry and Biochemistry Department Graduation
3. Specialty Chemical Forum 2012 Kicks Off in Houston; AkzoNobels Frank Sherman Delivers Keynote Address
4. Novel nanotherapeutic delivers clot-busting drugs directly to obstructed blood vessels
5. New technology delivers sustained release of drugs for up to 6 months
6. MarketsandMarkets: Lung Cancer Drugs Market in G7 Countries Worth $13 Billion by 2020
7. FDAs Oncologic Drugs Advisory Committee to Review Resubmitted Pixantrone New Drug Application on February 9, 2012
8. DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs
9. New drugs show promise for preventing absence seizures in children: UBC research
10. Islet Sciences Announces DiaKine Therapeutics Novel Diabetes, Atherosclerosis Drugs Receives European Patent Protection
11. Researchers reveal why some pain drugs become less effective over time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... 2014 HealthTronics, Inc. , ... radiology products and services, has signed a distribution ... Clinicon Corporation for its high precision laser ... minimally invasive, mobile, surgical technology—offering more choices for ... agreement, HealthTronics will make available Clinicon’s FDA-cleared SureLase™ ...
(Date:9/19/2014)... crop yields to disease risks, the biological characteristics people ... Just as for heightthe textbook example of a complex ... shaped by multiple genetic and environmental influences, making it ... such genes, geneticists typically mate two individuals that differ ... small mouseand then study their descendents, looking for genes ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 ... its potential to revolutionize the world has attracted ... corporations and small start-ups. The early years of ... projects largely due to the high risks involved, ... budgets earmarked for this evolving technology have been ...
(Date:9/19/2014)... 2014  Nektar Therapeutics (NASDAQ: NKTR ... the analgesic profiles of a series of the ... molecules. The preclinical research candidates were created using ... The analgesic properties of kappa receptor agonism ... Kappa opioid receptors are expressed in the ...
Breaking Biology Technology:HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3Want to link genes to complex traits? Start with more diversity 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5
... Hammer LLC , a software company in Waukesha that sells ... design programs, said on Thursday it has been acquired by ... announced it would expand its offerings to manufacturers and retailers ... products, and product pictures. Big Hammer operates one of 11 ...
... of research in the history of the University of ... its image from a university of access to a ... build a knowledge-based economy. , ,Abbas Ourmazd, keynote speaker ... Awards, appealed for support for UWMs Research Growth Initiative. ...
... said on Tuesday that a patent it has just ... property in the U.S. , ,The patent covers a combination ... a type of chain reaction that makes copies of DNA ... its existing Invader chemistry. , ,"These important, new patents are ...
Cached Biology Technology:Tech awards keynoter asks for support of UWM transformation 2Tech awards keynoter asks for support of UWM transformation 3
(Date:9/19/2014)... 19, 2014 Nxt-ID, Inc. (Nasdaq: NXTD ... on the growing m-commerce market, updates the "Wocket in Your Pocket" ... lightweight and light middleweight weight classes, Vinny Pazienza (PAZ). ... that Game of Thrones actor Ciaran Hinds ... star Katey Sagal have been cast in ...
(Date:9/18/2014)... - Washington State University researchers have developed a unique ... power waste cleanup in rural areas. , The ... an inexpensive and quick way to clean up waste ... while reducing pollution. , Professor Haluk Beyenal and ... Engineering and Architecture discuss the system in the online ...
(Date:9/18/2014)... located deep in the primitive brainstem has revealed how ... Harvard School of Medicine and the University at Buffalo ... the second "sleep node" identified in the mammalian brain ... to produce deep sleep. , Published online in August ... fully half of all of the brain,s sleep-promoting activity ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3Researchers develop unique waste cleanup for rural areas 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... combined genetic and geographic data of the H5N1 avian ... decade. They found that multiple strains of the virus ... identified many of the migration routes through which the ... H5N1 strains develop and migrate, health officials can better ...
... brewing about whether pre-Columbian Amazonian populations settled in large ... that many conservationists take to be ‘natural.' , This ... and is challenged in a recent paper from Dr. ... findings of Bush’s research may rekindle a debate has ...
... genes from an ancient wheat variety have led to a ... recent set of papers published in the journal Plant Physiology ... Nax2. The genes work by excluding salt from different parts ... the leaves. The discovery of the two genes is the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Paper challenges 1491 Amazonian population theories 2Paper challenges 1491 Amazonian population theories 3Paper challenges 1491 Amazonian population theories 4Ancient genes used to produce salt-tolerant wheat 2
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
recombination at attR1 and attR2 sites...
...
GlutaMAX-I Supplement...
Biology Products: