Navigation Links
Slow-release 'jelly' delivers drugs better
Date:1/28/2013

DURHAM, NC -- Duke University biomedical engineers have developed a new delivery system that overcomes the shortcomings of a promising class of peptide drugs very small proteins for treating diseases such as diabetes and cancer.

There are more than 40 peptide drugs approved for use in humans and more than 650 are being tested in clinical studies. One example is the hormone insulin, a peptide that regulates the metabolism of carbohydrates in the body and is used as a drug to treat diabetes.

Despite their effectiveness, peptide drugs cannot achieve their full potential for a number of reasons. They are rapidly degraded in the blood stream and they are cleared rapidly from the body, which requires multiple, frequent injections. Because of this, peptide concentrations in the blood can rise precipitously just after injection and fall dramatically soon thereafter, causing unwanted side effects for patients.

One popular method to solve this problem involves loading peptide drugs into polymer microspheres that are injected under the skin and slowly degrade to release the peptide drug. Microsphere-release technology has proven useful, but has many issues related to its manufacture and ease of patient use, the researchers said.

"We wanted to know if we could create a system that does what the polymer microspheres do, but gets rid of the microspheres and is more patient-friendly," said Ashutosh Chilkoti, Theo Pilkington professor of biomedical engineering in Duke's Pratt School of Engineering.

The new approach involves making a "fusion protein" that consists of multiple copies of a peptide drug fused to a polymer which is sensitive to body heat. The fusion molecule is a liquid in a syringe but transforms into a "jelly" when injected under the skin. Enzymes in the skin then attack the injected drug depot and liberate copies of the peptide, providing a constant and controllable release of the drug over time.

Miriam Am
'/>"/>

Contact: Richard Merritt
richard.merritt@duke.edu
919-660-8414
Duke University
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Jellyfish inspires latest ocean-powered robot
2. CEM President and CEO Delivers Commencement Address at the 2012 University of Texas at Austin Chemistry and Biochemistry Department Graduation
3. Specialty Chemical Forum 2012 Kicks Off in Houston; AkzoNobels Frank Sherman Delivers Keynote Address
4. Novel nanotherapeutic delivers clot-busting drugs directly to obstructed blood vessels
5. New technology delivers sustained release of drugs for up to 6 months
6. MarketsandMarkets: Lung Cancer Drugs Market in G7 Countries Worth $13 Billion by 2020
7. FDAs Oncologic Drugs Advisory Committee to Review Resubmitted Pixantrone New Drug Application on February 9, 2012
8. DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs
9. New drugs show promise for preventing absence seizures in children: UBC research
10. Islet Sciences Announces DiaKine Therapeutics Novel Diabetes, Atherosclerosis Drugs Receives European Patent Protection
11. Researchers reveal why some pain drugs become less effective over time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... (Frankfurt Stock Exchange: EVT) today announced that Jörn,Aldag, President & CEO, ... Date: Tuesday, ... 11.45 am EST (05.45 pm CET/04.45 pm GMT) Location: ... will be available on the Evotec website at, http://www.evotec.com - ...
... . , ANN ARBOR, Mich.---A new energy-capturing knee ... a portable GPS locator, a cell phone, a motorized ... University of Michigan shows. , A report on the ... the journal Science. Authors include researchers from Simon Fraser ...
... BRISBANE, Calif., Feb. 7 InterMune, Inc.,(Nasdaq: ITMN ) ... ended December 31, 2007. The company also provided 2008,financial guidance ... the Fourth Quarter 2007, InterMune reported a net loss ... per share, compared with a net loss of $21.5 million, ...
Cached Biology Technology:Knee brace generates electricity from walking 2InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 2InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 3InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 4InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 5InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 6InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 7InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 8InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 9InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 10InterMune Announces Fourth Quarter and Full Year 2007 Financial Results and Provides 2008 Guidance 11
(Date:4/17/2014)... University (ANU), have developed a new way to ... the past 5.3 million years., The findings will ... ages over the past two million years, and ... levels, global temperatures and sea levels., The team ... the National Oceanography Centre (NOC) in the United ...
(Date:4/16/2014)... species of yellow-shouldered bats have been unearthed by scientists at the ... History and described in the open access journal ZooKeys ... are part of a recent discovery of three bats hidden ... to be officially announced. , Up until recently the genus ...
(Date:4/16/2014)... Doucet of the Centre INRSInstitut Armand-Frappier has just received a ... the amount of nearly US$600,000. The 5-year grant is to ... RNases and to explore their biomedical potential in the field ... , "Receiving a grant at this level is an ...
Breaking Biology News(10 mins):Ancient sea-levels give new clues on ice ages 2Two new species of yellow-shouldered bats endemic to the Neotropics 2High-level NIH grant goes to professor Nicolas Doucet of INRS 2
... Embryonic stem cells, prized for their astonishing ability to apparently ... their identities in part by interacting with their surroundings - ... laboratory dish, University of Florida scientists report. , Using an ... McKnight Brain Institute have begun to answer one of the ...
... fact, beneficial microbes could represent the future of medicine, ... in humans and animals from diarrhea and eczema to ... released by the American Academy of Microbiology, Probiotic Microbes: ... used to treat a range of clinical conditions that ...
... have discovered a new gene that could lead to ... diabetes. , The gene, called SLIRP, was discovered by ... Research's (WAIMR) Laboratory for Cancer Medicine, led by Professor ... at Baylor College of Medicine in Texas. , "When ...
Cached Biology News:Birds going extinct faster due to human activities 2Birds going extinct faster due to human activities 3Report focuses on the role good microbes play in future medicine 2Gene discovery opens door to tackling disease 2
... protein ribonuclease inhibitor that noncovalently binds and inactivates ... seen with RNase 1, T1, T2, H, U1, ... placental ribonuclease inhibitor in that it has a ... release active RNase in the absence of DTT ...
... (Chemical Inkjet Printer) is a revolutionary ... and Protein Macroarray Analysis, developed in ... The strategy compliments established protocols in ... the proteins isoelectric point and apparent ...
... The BIOLASE Core Kit ... to perform polymerase assays on ... templates. In addition to dNTPs, ... on our widely used BIOLASE ...
Canine Aortic Smooth Muscle Cells (CnAOSMC) (>500,000 cells)...
Biology Products: