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Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products
Date:3/12/2008

ROCKVILLE, Md., March 12 /PRNewswire/ -- General Research Laboratory, Inc. (GRL) and Sirnaomics, Inc. announced today that the companies are advancing their partnership initiated in July 2007 for development of two RNA interference (RNAi) therapeutic products, following the successful identification of siRNA inhibitors for multi-targeted siRNA cocktail approaches, through a series of in silico and in vitro studies, using Sirnaomics' Tri-Blocker(TM) technology.

Under the terms of the agreement, Sirnaomics and GRL will jointly focus on developing two multi-targeted RNAi therapeutic products to improve scarless skin wound healing and to treat prostate cancer. The first product is expected to consist of three siRNA duplexes targeting three genes involved in scar formation during the skin wound healing process. The further in vivo study will demonstrate that the siRNA/polymeric nanoparticle formulation with topical cream application is able to enhance the wound healing process with minimum scar formation. The second product is defined as an siRNA cocktail targeting three tumor causing genes delivered with Epoxy Encapsulated Magnetic Nanoparticles (EEMNP) system. Using this local and in vivo administration approach will greatly enhance the therapeutic benefit for treatment of prostate carcinoma.

Under the terms of the agreement, GRL will provide Sirnaomics with research funding and access to lab and office space. Sirnaomics will receive milestone payments at key points in the development process and product royalty payments when these products reach the market. "We are very pleased to have this partnership with GRL which not only provides us with financial resources but also validates our product development strategy," said Dr. Patrick Lu, Founder, President and CEO of Sirnaomics, Inc. "We will continue seeking additional partnerships for our multi-targeted siRNA therapeutic approach, either from large pharmaceutical and major biotech companies, or fr
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SOURCE Sirnaomics, Inc.
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