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Sirnaomics Receives Two SBIR Grants from NIH for Developing siRNA Therapeutics to Treat Glioblastoma and Influenza Infection
Date:6/29/2010

ry systems in three generations: the self-assembled nanoparticles (1st ), ligand-directed nanoparticles (2nd)  and infrared-activated nanoparticles (3rd), for various types of therapeutic applications.  The company's siRNA therapeutic programs currently are under development for treatment of cancer, respiratory infections, scarless wound healing and others.

"Receiving an SBIR grant from NCI for development of siRNA therapeutics to treat Glioblastoma has further demonstrated the scientific merits of Sirnaomics' siRNA therapeutic program on oncology using multi-targeted siRNAs with nanoparticle-enhanced delivery," said the President and CEO of the company, Dr. Patrick Y. Lu, also the Principal Investigator of the grant from NCI. "The collaboration among scientists and clinicians from Sirnaomics and Duke University provides the solid foundation for the success of such a novel therapeutic approach," Dr. Lu further emphasized. "Continuous government funding is critical for the growth of a therapeutic product company like Sirnaomics, especially in the current financial environment."

"An siRNA therapeutic is uniquely positioned to combat emerging viral infections such as influenza H5N1 and H1N1 since a single siRNA sequence can be designed with exquisite selectivity against each viral gene segment. siRNAs can be rapidly synthesized at large scale and are easily administered through inhalation (or systemically). Sirnaomics patented approach to target multiple viral gene segments has further benefit in preventing viral escape from therapeutic pressure. Consequently, siRNA therapies may provide a better therapeutic option in fighting an influenza pandemic," said the Vice President for Discovery Research of the company, Dr. David Evans, who is also the Principal Investigator of another grant from NIAID.
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