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Sirnaomics Receives SBIR Grant from NCI For Its Multi-Targeted Cancer siRNA Therapeutics

GAITHERSBURG, Md., Oct. 28 /PRNewswire/ -- Sirnaomics, Inc. ( announced today that the company has received an SBIR (small business innovation research) grant from National Cancer Institute (NCI), National Institute of Health (NIH). Sirnaomics, Inc., a biopharmaceutical company founded in early 2007, is dedicated to advancing RNA interference (RNAi) Technology for novel targeted therapeutic development. The company's multi-targeted siRNA therapeutic programs utilizing its nanoparticle-enhanced delivery technologies represent a unique approach for truly realizing the advantages of small interfering RNA (siRNA)-based drugs to treat various critical human diseases. Sirnaomics has successfully attracted grants and investments from the State of Maryland (Department of Business and Economics Development -- DBED), Maryland Industrial Partnerships (MIPS) and Montgomery County Technology Growth Programs (TGP), in addition to the State of Maryland Tax Credit Program for Biotechnology Investment.

RNAi has emerged as a fundamentally important biological phenomenon and as a versatile, powerful tool for biomedical research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenger RNA. Experimental applications of RNAi have spurred the exploration of gene function in many basic research, drug discovery and clinical settings. The 2006 Nobel Prize for medicine and physiology and a number of corporate acquisitions and investments by Novartis, Merck, AstraZeneca, Roche and Takeda have injected billions of dollars into this novel technology and further fueled the enthusiasm for the great promise of siRNA therapeutics development.

Sirnaomics' mission is to advance RNAi technology by using its proprietary multi-targeted siRNA cocktail design together with the company's nanoparticle- mediated siRNA delivery vehicles in the rapid delivery of novel therapeutics. The company is dedicated to becoming the leader in the field of RNAi technology and its strong ties with biopharmaceutical communities in Asia (China) will allow the company to speed up its pre-clinical and clinical processes for novel siRNA therapeutic development at reduced cost. The company's proprietary "Tri-Blocker" technology for multi-targeted siRNA cocktail design and "Snano" series of nanoparticle delivery systems enable its advanced RNAi therapeutic programs for treatment of various critical human conditions including ocular diseases, viral infections, scarless wound repair and cancer.

"Receiving an SBIR grant from NCI further validates the scientific and business merits of our cancer therapeutic program using multi-targeted siRNA cocktails," said the founder, President and CEO of the company, also the Principle Investigator of the grant proposal, Dr. Patrick Y. Lu. "It is a successful extension of Sirnaomics product pipeline for siRNA therapeutics including the programs for ocular diseases, respiratory infectious diseases and scarless wound healing in their late stage of pre-clinical development." Dr. Lu further emphasized that the grants from various Government agencies provide a sustainable funding resource to the company in addition to its corporate partnership deals and venture capital investments. "Funding from Government is uniquely important for an early stage company like Sirnaomics, especially in the current financial environment."

Sirnaomics, Inc. is a privately held Delaware corporation headquartered in Gaithersburg, Maryland, USA. Established by a group of leading scientists in the field of RNAi technology, the company has the mission of advancing RNAi technology for novel drug discovery and targeted therapeutics development. After completing a pre-IND meeting with the FDA earlier this year, its leading siRNA therapeutic product, STP601, is expected to enter the clinic in 2009. Members of the senior management team bring over 50 years of combined experience in the biopharmaceutical, financial and business management industries and will ensure the healthy growth of Sirnaomics as an international biopharmaceutical enterprise.


George J. Ji, MBA

Sirnaomics, Inc.

401 Professional Drive, Suite 130

Gaithersburg, MD 20879, USA

301-740-1730 Phone

301-740-1731 FAX

SOURCE Sirnaomics, Inc.
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